Results 161 to 170 of about 158,395 (286)

Perampanel Blocks Transsynaptic α‐Synuclein Propagation and Neurodegeneration in a Mouse Model of Lewy Body Disease

Movement Disorders, EarlyView.
Abstract Background Transsynaptic α‐synuclein propagation plays a crucial role in the progression of Lewy body disease. We previously demonstrated that an α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor antagonist, perampanel, blocks neuronal uptake of α‐synuclein preformed fibrils (PFFs) in an activity‐dependent manner.
Jun Ueda, Norihito Uemura, Jiarui Chang, Tetsuya Hirato, Tomoyuki Ishimoto, Miki Oono, Shuichi Matsuzawa, Riki Matsumoto, Hodaka Yamakado, Ryosuke Takahashi   +9 more
wiley   +1 more source

The ketogenic diet alters microbiome‐metabolome profiles to improve West syndrome therapy

Pediatric Investigation, EarlyView.
The ketogenic diet alleviates West syndrome by reshaping gut microbiota (increasing Bacteroides, Parabacteroides, and reducing Escherichia and Bifidobacterium), and modulating metabolites—including anticonvulsant lipids (e.g., capric acid), suppressed harmful lipids (e.g., 2‐methylbutyroylcarnitine), and amino acids and analogs (e.g., 3‐sulfinoalanine)—
Gan Xie, Qian Zhou, Jianxiang Liao, Yuejie Zheng, Wenjian Wang, Kunling Shen   +5 more
wiley   +1 more source

Comparative Evaluation of Three Immunoassays for the Simultaneous Detection of Clostridioides difficile Glutamate Dehydrogenase and Toxin A/B. [PDF]

Microorganisms, 2022
Kim N, Lee SY, Park J, Lee J.
europepmc   +1 more source

Glutamate dehydrogenase 2 is required for virulence by facilitating fungal growth in the host hemocoel. [PDF]

Virulence
Lu Y, Wu D, Hu J, Peng G, Zhong J, Liu Y, Li J, Gao Q, Yu XQ.   +8 more
europepmc   +1 more source

Glutamate Dehydrogenase Functions in Glutamic Acid Metabolism and Stress Resistance in Pyropia haitanensis. [PDF]

Molecules, 2021
Li S, Shao Z, Lu C, Yao J, Zhou Y, Duan D.   +5 more
europepmc   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Rieske Iron–Sulfur Cluster Proteins From an Anaerobic Ammonium Oxidizer Suggest Unusual Energetics in Their Parent Rieske/Cytochrome b Complexes

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Anaerobic ammonium‐oxidizing (anammox) bacteria employ a unique, hydrazine‐based pathway to obtain energy from nitrite and ammonium. These organisms possess distinct Rieske/cytochrome b complexes whose precise role in anammox metabolism remains unclear, but which have been proposed to include the generation of NAD(P)H.
David Hauser, Mandy Sode, Elena A. Andreeva, Kristian Parey, Thomas R. M. Barends   +4 more
wiley   +1 more source

Glutamate Dehydrogenase (GdhA) of Streptococcus pneumoniae Is Required for High Temperature Adaptation. [PDF]

Infect Immun, 2021
Gazioglu O, Kareem BO, Afzal M, Shafeeq S, Kuipers OP, Ulijasz AT, Andrew PW, Yesilkaya H.   +7 more
europepmc   +1 more source

Glutamate dehydrogenase from Pantoea ananatis: A new bacterial enzyme with dual coenzyme specificity. [PDF]

PLoS One
Kharchenko MS, Skripnikova VS, Rostova JG, Zakataeva NP.   +3 more
europepmc   +1 more source

A Legionella effector ADP-ribosyltransferase inactivates glutamate dehydrogenase. [PDF]

J Biol Chem, 2021
Black MH, Osinski A, Park GJ, Gradowski M, Servage KA, Pawłowski K, Tagliabracci VS.   +6 more
europepmc   +1 more source