Results 211 to 220 of about 90,755 (258)

Alternative substrates for glutamate dehydrogenases

Biochemical and Biophysical Research Communications, 1975
Summary The amide group of glutamine functions as a nitrogen donor in the reactions catalyzed by both the NADP-specific glutamate dehydrogenase of Neurospora crassa and the bovine liver enzyme, but not by the NAD-specific Neurospora enzyme. Asparagine serves as nitrogen source only for the NADP-specific Neurospora dehydrogenase.
K M, Blumenthal, E L, Smith
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Chymotryptic activation of glutamate dehydrogenase

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1983
Treatment of bovine liver glutamate dehydrogenase (L-glutamate:NAD(P)+ oxidoreductase (deaminating), EC 1.4.1.3) with chymotrypsin generates a proteolytic derivative that is activated 3-4-fold over the native enzyme. Stable preparations of activated enzyme show altered kinetic parameters (5-fold increase in Km for glutamate, 3-fold increase in Vmax ...
G A, Place, R J, Beynon
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Kinetic mechanism of glutamate dehydrogenase

Biochemistry, 1980
Initial velocity patterns and dead-end inhibition studies with oxalylglycine suggest that the addition of NADPH, keto acid, and ammonia occurs with obligatory order. For monocarboxylic keto acids, the keto acid-ammonia initial velocity pattern is equilibrium ordered because koff is much greater than Vmax.
J E, Rife, W W, Cleland
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Bovine Liver Glutamate Dehydrogenase

1976
Publisher Summary This chapter discusses the current ideas on the catalytic reaction of glutamate dehydrogenase, including its mechanism and regulation, substrate inhibition or activation, the binding of coenzymes to the enzyme, the effect of purine nucleotides, and the mechanism of ligand-induced structural changes.
H, Eisenberg, R, Josephs, E, Reisler
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Myocardial Glutamate Dehydrogenase Activity

1986
Glutamic dehydrogenase (GDH) has not been thought to play an important role in cardiac metabolism in the past. Aspartate aminotransferase was shown to mediate glutamate utilization by mitochondria and there was thought to be little GDH activity in heart mitochondria.1 However, the studies of Godinot et al showed that this enzyme could be purified from ...
H G, McDaniel, R L, Jenkins
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Conformers of Neurospora glutamate dehydrogenase

Journal of Molecular Biology, 1969
Abstract Subunits of Neurospora glutamate dehydrogenase were prepared by treating the enzyme with 6 m -urea, 7 m -guanidinium chloride or 0.2% sodium dodecyl sulphate. Antisera were prepared against the enzyme and the various subunits. These antisera were used in anti-enzyme and precipitation studies with the enzyme and the various subunits.
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Glutamate dehydrogenase of Drosophila larvae

Journal of Insect Physiology, 1968
Abstract Larvae of Drosophila contain a glutamate dehydrogenase which is localized mainly in the mitochondria. The enzyme operates with either NAD or NADP as coenzyme, and is unusual in that NAD is more readilyutilized in one reaction whereas NADPH is more efficient in the other.
P A, Bond, J H, Sang
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The Radiation Inactivation of Glutamate Dehydrogenase

Radiation Research, 1983
Pulse radiolysis and 60Co gamma radiolysis were used to study the effects of ionizing radiations on the activity of glutamate dehydrogenase. Hydroxyl radicals are considerably more effective than hydrated electrons in causing loss of enzymatic activity. Evidence is also presented that the free radical anions (SCN)-.2, (Br)-.2, and (I)-.2 react with the
R R, Abu El Failat, J S, Moore, J V, Davies   +2 more
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A kinetic model for glutamate dehydrogenase

Journal of Theoretical Biology, 1977
Abstract A model for the glutamate dehydrogenase reaction has been obtained that contains the reported intermediates suggested by binding and equilibrium isotope exchange methods. Calculated steady state-initial velocity rates using this model are quantitatively consistent with a wide range of nonlinear experimental data in both directions.
B D, Wells, L A, Parks, I, Tam, J R, Fisher   +3 more
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Serum isocitric dehydrogenase and glutamic dehydrogenase in schistosomiasis

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1969
Abstract 19 patients with schistosomiasis were studied for serum ICDH and GLDH activities; they were divided into two groups according to the presence or absence of hepatic involvement. Serum ICDH levels were normal, except in one patient with advanced hepatic decompensation.
Y, Mohran, K, Bsmi, M S, Shoeb, M R, Zawahiri, Y A, Ghaffer   +4 more
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