Results 21 to 30 of about 90,755 (258)

The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis

RNA Biology, 2023
The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated ...
Tao Shen, Haiyang Wang, Bin Tang, Guoping Zhu, Xiangting Wang   +4 more
doaj   +1 more source

Oxoglutarate dehydrogenase complex controls glutamate-mediated neuronal death

Redox Biology, 2023
Brain injury is accompanied by neuroinflammation, accumulation of extracellular glutamate and mitochondrial dysfunction, all of which cause neuronal death. The aim of this study was to investigate the impact of these mechanisms on neuronal death.Patients
Adelheid Weidinger, Nadja Milivojev, Arthur Hosmann, J. Catharina Duvigneau, Csaba Szabo, Gabor Törö, Laurin Rauter, Annette Vaglio-Garro, Garik V. Mkrtchyan, Lidia Trofimova, Rinat R. Sharipov, Alexander M. Surin, Irina A. Krasilnikova, Vsevolod G. Pinelis, Laszlo Tretter, Rudolf Moldzio, Hülya Bayır, Valerian E. Kagan, Victoria I. Bunik, Andrey V. Kozlov   +19 more
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Metabolism of excised embryos of Lupinus luteus L. VI. An electrophoretic analysis of some dehydrogenases in cultured embryos as compared with the normal seedling axes

Acta Societatis Botanicorum Poloniae, 2015
The electrophoretic patterns (disc electrophoresis) of the studied dehydrogenases: glucose-6-phosphate - (A), malate - (B), glutamate - (C), alcohol - (D) and lactate dehydrogenase (E), in the axial organs of isolated Lupinus luteus embryos and seedlings
J. Czosnowski
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Flow Injection Glutamate Biosensor Based on Carbon Nanotubes and Pt-Nanoparticles Using FFT Continuous Cyclic Voltammetry

International Journal of Electrochemical Science, 2010
Glutamate concentration was measured by a novel glutamate dehydrogenase biosensor in a flow injection analysis (FIA) system. The measurement method was based on application of fast Fourier transformation continuous cyclic voltammetry (FFTCCV) in which ...
P. Norouzi, F. Faridbod, H. Rashedi, M.R. Ganjali   +3 more
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Inhibitors of glutamate dehydrogenase block sodium-dependent glutamate uptake in rat brain membranes

Frontiers in Endocrinology, 2013
We recently found evidence for anatomic and physical linkages between the astroglial Na+-dependent glutamate transporters (GLT-1/EAAT2 and GLAST/EAAT1) and mitochondria.
Brendan S Whitelaw, Michael B Robinson, Michael B Robinson, Michael B Robinson   +3 more
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Differential Levels of Glutamate Dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 Mice and the Effects of Overexpression of the Gene on Glutamate Release in Striatum

ASN Neuro, 2011
We have previously shown that overexpression of the Glud1 (glutamate dehydrogenase 1) gene in neurons of C57BL/6 mice results in increased depolarization-induced glutamate release that eventually leads to selective neuronal injury and cell loss by 12 ...
Kevin N Hascup, Xiaodong Bao, Erin R Hascup, Dongwei Hui, Wenhao Xu, Francois Pomerleau, Peter Huettl, Mary L Michaelis, Elias K Michaelis, Greg A Gerhardt   +9 more
doaj   +1 more source

Filamentous invasive growth of mutants of the genes encoding ammonia-metabolizing enzymes in the fission yeast Schizosaccharomyces pombe. [PDF]

PLoS ONE, 2017
The fission yeast Schizosaccharomyces pombe undergoes a switch from yeast to filamentous invasive growth in response to certain environmental stimuli. Among them is ammonium limitation.
Yoshie Sasaki, Ayumi Kojima, Yuriko Shibata, Hiroshi Mitsuzawa   +3 more
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Platelet glutamate dehydrogenase activity and efficacy of antipsychotic therapy in patients with schizophrenia [PDF]

Journal of Medical Biochemistry, 2020
Background: Evaluation of possible relationship between platelet glutamate dehydrogenase (GDH) activity and mental state of schizophrenia patients after antipsychotic pharmacotherapy. Methods: Patients (n = 50) with chronic paranoid schizophrenia (F20.0)
Savushkina Olga K., Tereshkina Elena B., Prokhorova Tatiana A., Boksha Irina S., Burminskii Denis S., Vorobyeva Elena A., Morozova Margarita A., Burbaeva Gulnur Sh.   +7 more
doaj  

Central Role of Glutamate Metabolism in the Maintenance of Nitrogen Homeostasis in Normal and Hyperammonemic Brain

Biomolecules, 2016
Glutamate is present in the brain at an average concentration—typically 10–12 mM—far in excess of those of other amino acids. In glutamate-containing vesicles in the brain, the concentration of glutamate may even exceed 100 mM. Yet because glutamate is a
Arthur J. L. Cooper, Thomas M. Jeitner
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Interaction of 4-Aminobutyrate (GABA) with the Tricarboxylic Acid Cycle in Plants Under Salinity Stress

Plants
The 4-aminobutyrate (GABA) shunt bypasses 2-oxoglutarate dehydrogenase and succinyl-CoA synthetase in the tricarboxylic acid cycle (TCAC) by diverting 2-oxoglutarate to glutamate and generating GABA via glutamate decarboxylase (GAD), whereas polyamine ...
Edward J. Flaherty, Barry J. Shelp
doaj   +1 more source