A theoretical study of the role of astrocyte activity in neuronal hyperexcitability using a new neuro-glial mass model [PDF]
arXiv, 2015 The investigation of the neuronal environment allows us to better understand the activity of a cerebral region as a whole. The recent experimental evidences of the presence of transporters for glutamate and GABA in both neuronal and astrocyte compartments raise the question of the functional importance of the astrocytes in the regulation of the ...
arxiv
The role of glutamate dehydrogenase in the ageing brain
Frontiers in PharmacologyThe homeostasis of glutamate, the primary excitatory neurotransmitter in the brain and is crucial for normal brain function. The mitochondrial enzyme glutamate dehydrogenase (GDH) connects the multifunctional amino acid glutamate, which is intimately ...
Tao Zhou, Haichuan Wang
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A Molecular Communication Perspective of Alzheimer's Disease: Impact of Amyloid Beta Oligomers on Glutamate Diffusion in the Synaptic Cleft [PDF]
arXivMolecular communication (MC) within the synaptic cleft is vital for neurotransmitter diffusion, a process critical to cognitive functions. In Alzheimer's Disease (AD), beta-amyloid oligomers (A$\beta$os) disrupt this communication, leading to synaptic dysfunction.
arxiv
Impact of Co-Excipient Selection on Hydrophobic Polymer Folding: Insights for Optimal Formulation Design [PDF]
arXivThe stabilization of liquid biological products is a complex task that depends on the chemical composition of both the active ingredient and any excipients in solution. Frequently, a large number of unique excipients are required to stabilize biologics, though it is not well-known how these excipients interact with one another. To probe these excipient-
arxiv
Animal Nutrition, 2018 The liver is the most essential organ for the metabolism of ammonia, in where most of ammonia is removed by urea and glutamine synthesis. Regulated by leucine, glutamate dehydrogenase (GDH) catalyzes the reversible inter-conversion of glutamate to ...
Tongxin Wang +5 more
doaj
Regulation of Glutamate Dehydrogenases During Morphogenesis of Schizophyllum commune [PDF]
, 1967 David W. Dennen, Donald J. Niederpruem
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Adjunctive perampanel for glioma-associated epilepsy
Epilepsy and Behavior Case Reports, 2018 Glioma-associated epilepsy is associated with excessive glutamate signaling. We hypothesized that perampanel, an amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor antagonist, would treat glioma-related epilepsy.
Anastasie M. Dunn-Pirio +9 more
doaj
Fluorescence Studies of Zinc Binding to Beef Liver Glutamate Dehydrogenase. [PDF]
, 1965 Horst Sund +5 more
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Immunochemical and Enzymatic Studies on Glutamate Dehydrogenase and a Related Mutant Protein fromNeurospora crassa [PDF]
, 1966 David B. Roberts
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1-Anilinonaphthalene-8-sulphonate, a fluorescent conformational probe for glutamate dehydrogenase [PDF]
, 1969 George H. Dodd, G. K. Radda
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