Results 241 to 250 of about 396,749 (354)

Microcondensate‐Mediated Intracellular Infusion of mRNA Across the Plasma Membrane

Angewandte Chemie, EarlyView.
The delivery of mRNA without lipid nanoparticles remains challenging. FcB(L17E)3‐driven microcondensates with nucleic acids, aided by short ssDNA, enable coacervate formation, actin‐dependent cytosolic infusion, and in vivo protein expression, offering a potential platform for next‐generation mRNA therapeutics and vaccination.
Yoshimasa Kawaguchi, Ayumi Kikkawa, Seigo Kimura, Hiroshi Abe, Shiroh Futaki   +4 more
wiley   +2 more sources

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation. [PDF]

Sci Transl Med
Zhang YR, Keshari S, Kurihara K, Liu J, McKendrick LM, Chen CS, Yang Y, Falo LD, Das J, Sumpter TL, Kaplan DH.   +10 more
europepmc   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Spontaneous partial resolution of autoimmune-mediated brain MRI abnormalities before immunotherapy in anti-metabotropic glutamate receptor 5 encephalitis: a case report. [PDF]

Front Immunol
Chen J, Tang X, Wang L, Guo D, Cao L, Lu K.   +5 more
europepmc   +1 more source

Glutamate Signaling and NMDA Receptor Dynamics in Healthy Aging and Alzheimer’s Disease

Ammarah Baig, Javeria Tanveer, Rukhsana Rubeen, Sadaf Shakoor, Kanza Khan, Kaneez Fatima-Shad   +5 more
openalex   +2 more sources

Endocannabinoids Generated by Ca2+ or by Metabotropic Glutamate Receptors Appear to Arise from Different Pools of Diacylglycerol Lipase

, 2011
Longhua Zhang, Meina Wang, Tiziana Bisogno, Vincenzo Di Marzo, Bradley E. Alger   +4 more
openalex   +2 more sources

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, EarlyView.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Tau pathology is associated with postsynaptic metabotropic glutamate receptor 5 (mGluR5) in early Alzheimer's disease in a sex-specific manner. [PDF]

Alzheimers Dement
Wang Y, Wang J, Chen X, Lin Z, You Z, He K, Guo T, Zhao J, Huang Q, Ni R, Guan Y, Li B, Xie F.   +12 more
europepmc   +1 more source

Role of metabotropic glutamate receptors in intracellular calcium homeostasis

, 1997
Jarda T. Wroblewski, Alexander Surin, Sergey Pshenichkin   +2 more
openalex   +1 more source