Results 221 to 230 of about 1,540,702 (294)

Coordinated actions of NLR-assembled and glutamate receptor-like calcium channels in plant effector-triggered immunity. [PDF]

Proc Natl Acad Sci U S A
Wang J, Sun X, Xiong F, Lapin D, Lee T, Martin-Ramirez S, Prakken A, Shen Q, Bautor J, Maekawa T, Parker JE.   +10 more
europepmc   +1 more source

A Conserved Isoleucine Gates the Diffusion of CO and O2 to the Active Site of NiFe CO‐Dehydrogenase

Angewandte Chemie, EarlyView.
A combination of protein film electrochemistry and site‐directed mutagenesis shows that isoleucine 563 (numbering of Thermococcus sp. AM4) gates the arrival of both CO and O2 to the active site of the nickel‐iron CO dehydrogenases. Mutations at this position increase the resistance to O2 at the cost of a slower reaction with CO.
Laura Opdam, Marta Meneghello, Chloé Guendon, Jade Chargelègue, Andrea Fasano, Aurore Jacq‐Bailly, Christophe Léger, Vincent Fourmond   +7 more
wiley   +2 more sources

Anti-Metabotropic Glutamate Receptor 5 Autoimmune Encephalitis with a Typical Alzheimer's Disease Biomarker Profile: A Case of Rapidly Progressive Dementia Unresponsive to Cholinesterase Inhibitors. [PDF]

Case Rep Neurol
Liu Y, Zhao J, Shi Z.
europepmc   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Human primary skeletal muscle cells express glutamate receptor GluR3, are activated by glutamate, and are affected by autoimmune GluR3B antibodies of epilepsy patients. [PDF]

Front Physiol
Levite M, Ilouz N, Harazi A, Goldberg-Stern H, Galun E, Mitrani-Rosenbaum S.   +5 more
europepmc   +1 more source

Radiosynthesis and evaluation of an ¹⁸F-labeled radioligand for imaging metabotropic glutamate receptor 3 with positron emission tomography. [PDF]

Am J Nucl Med Mol Imaging
Rong J, Zhao C, Chaudhary AF, Chen J, Li Y, Zhou X, Song Z, Sun Z, Gao Y, Feng S, Zhao T, Hu QL, Li C, Haider A, Patel J, Ran C, Yuan H, Liang SH.   +17 more
europepmc   +1 more source

Apo-state structure of the metabotropic glutamate receptor 5 transmembrane domain obtained using a photoswitchable ligand. [PDF]

Protein Sci
Kondo Y, Hatton C, Cheng R, Trabuco M, Glover H, Bertrand Q, Stierli F, Seidel HP, Mason T, Sarma S, Tellkamp F, Kepa M, Dworkowski F, Mehrabi P, Hennig M, Standfuss J.   +15 more
europepmc   +1 more source

Novel Isoindolin-1-one Derivatives as Metabotropic Glutamate Receptor Positive Allosteric Modulators. [PDF]

ACS Med Chem Lett
Li Y, Liang SH.
europepmc   +1 more source

Effects of all-trans retinoic acid on glutamate receptor expression and dendritic spine density in the hypothalamus of rats. [PDF]

Front Neurosci
Kai YZ, Xia C, Shan QH, Tang ZQ.
europepmc   +1 more source

Clinical spectrum and outcomes of anti-metabotropic glutamate receptor 5 encephalitis in Chinese patients: a case report and literature review. [PDF]

Front Immunol
Niu Z, Chen S, Wang J, Yu M, Ren J, Liu R, Guo J, Zhang N, Gao F, Hao H.   +9 more
europepmc   +1 more source