Results 221 to 230 of about 2,983,362 (305)

Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation. [PDF]

Sci Transl Med
Zhang YR, Keshari S, Kurihara K, Liu J, McKendrick LM, Chen CS, Yang Y, Falo LD, Das J, Sumpter TL, Kaplan DH.   +10 more
europepmc   +1 more source

Ranking of antiseizure medications in a panel of focal seizure models predicts their comparative efficacy in clinical add‐on trials in drug‐resistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Most antiseizure medications (ASMs) have been discovered by testing in animal models, which are generally thought to predict antiseizure activity in patients. However, it is not known whether any of these models (or a combination of models) can predict whether a novel ASM exhibits higher clinical efficacy in focal drug‐resistant ...
Wolfgang Löscher, Pavel Klein
wiley   +1 more source

A consensus roadmap for post‐traumatic epilepsy: Clinical biomarkers, research priorities, policy barriers, and pathways to interventional trials

Epilepsia, EarlyView.
Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier, Ilaria Lisi, Elaine K. O'Loughlin, Federico Moro, Edilberto Amorim, David L. Brody, Daniel J. Correa, Dominique Duncan, Pavel Klein, Firas H. Kobeissy, Wolfgang Löscher, Edward J. Needham, Asla Pitkänen, Mary Jo Pugh, Jack Somers, Annamaria Vezzani, Amy K. Wagner, Laura S. Lubbers, International Conference on PTE Attendees, Denes Agoston, Edilberto Amorim, Sneha Anand, Hibah Awwad, Ginevra Bayon, Naima Belhachemi, Akash Bera, Costanza Bertani, Guido Bertolini, David L. Brody, Serena Brusatori, Francesca Buffelli, Aurora Chiapperini, Mara Chioccola, Severn Churn, Daniel J. Correa, Ramon Diaz‐Arrastia, Chris Dulla, Dominique Duncan, Chiara Ferlito, Aristea Galanopoulou, Angela Galic, Heidi Matos Galicia, Bin Gu, William Haskins, Victoria Johnson, Nigel Jones, Lowie Joseph, Pavel Klein, Firas Kobaissy, Ilaria Lisi, David Loane, Luther Loose, Laura S. Lubbers, Wolfgang Löscher, Edoardo Mazzone, Melissa Miller, Federico Moro, Edward J. Needham, Irma Wati Ngadimon, Terence O’Brien, Elaine K. O’Loughlin, Asla Pitkanen, Mary Jo Pugh, Teresa Giovanna Ravizza, Giuseppe Remuzzi, Massimo Rizzi, Rossella Di Sapia, Tawfeeq Shekh‐Ahmad, Doug Smith, Jack Somers, Kevin Staley, Francesca Tribuzio, Alexandra Ulyanova, Gloria Vegliante, Annamaria Vezzani, Joost Wagenaar, Amy K. Wagner, Kevin W. Wang, Justin Weppner, Peter J. West, Karen Wilcox, John Wolf, Elisa R. Zanier   +82 more
wiley   +1 more source

Novel 6-Aryl isoindolin-1-one Derivatives as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 2. [PDF]

ACS Med Chem Lett
Li Y, Liang SH.
europepmc   +1 more source

Tau pathology is associated with postsynaptic metabotropic glutamate receptor 5 (mGluR5) in early Alzheimer's disease in a sex-specific manner. [PDF]

Alzheimers Dement
Wang Y, Wang J, Chen X, Lin Z, You Z, He K, Guo T, Zhao J, Huang Q, Ni R, Guan Y, Li B, Xie F.   +12 more
europepmc   +1 more source

Pharmacology, Signaling and Therapeutic Potential of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators. [PDF]

ACS Pharmacol Transl Sci
Kos JA, Langiu M, Hellyer SD, Gregory KJ.   +3 more
europepmc   +1 more source

Spontaneous partial resolution of autoimmune-mediated brain MRI abnormalities before immunotherapy in anti-metabotropic glutamate receptor 5 encephalitis: a case report. [PDF]

Front Immunol
Chen J, Tang X, Wang L, Guo D, Cao L, Lu K.   +5 more
europepmc   +1 more source

Differing Patterns of Ionotropic Glutamate Receptor Subunit Gene Expression in Paraventricular Hypothalamic Nucleus Subregions following Angiotensin II Hypertension in Male Mice and Female Mice with Advanced Ovarian Failure.

Neuroendocrinology
Sommer G, Hussein SO, Milner TA, Glass MJ.   +3 more
europepmc   +1 more source

The glutamate receptor antagonist ifenprodil inhibits hepatitis E virus infection. [PDF]

Antimicrob Agents Chemother
Klöhn M, Gömer A, He Q, Brown RJP, Todt D, Wang L, Steinmann E.   +6 more
europepmc   +1 more source