Bimetallic Plasmonic Nanozyme‐Based Microneedle for Synergistic Ferroptosis Therapy of Melanoma
Advanced Science, EarlyView.A microneedle (MN) patch that integrates novel bimetallic plasmonic nanozyme (BPNzyme) and traditional Chinese medicine β‐elemene (β‐ELE) has been rationally designed for ferroptosis pathway‐dependent combined therapy of melanoma. Abstract Melanoma is the most common malignant skin tumor, characterized by complexity, invasiveness, and heterogeneity ...
Wei Duan +11 more
wiley +1 more source
Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. [PDF]
, 1990 Francisco Zafra +4 more
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Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset
Advanced Science, EarlyView.This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu +9 more
wiley +1 more source
Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat [PDF]
, 1992 Ryuichi Shigemoto +2 more
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Multiscale Organization of Neural Networks in a 3D Bioprinted Matrix
Advanced Science, EarlyView.A 3D bioprint model of primary neurons has been engineered with a millimeter‐scale functional neural network, and it recapitulates in vivo transcriptomic features under both normal and disease conditions to the greatest extent. The successful integration of mature neurons and 3D bioprinting signifies a major advance in neuroscience modeling ...
Huiyu Yang +16 more
wiley +1 more source
Genomics and transcriptomic alterations of the glutamate receptors in acute myeloid leukemia. [PDF]
Clin Transl Sci, 2023 Alqahtani A, Wang M, Lou M, Alachkar H.
europepmc +1 more source
Metabotropic glutamate receptors trigger postsynaptic protein synthesis.
, 1993 Ivan Jeanne Weiler, William T. Greenough
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Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label
Advanced Science, EarlyView.The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong +11 more
wiley +1 more source
Angewandte Chemie, EarlyView.Pt‐Luc was developed as a pioneering bioluminescent reporter for real‐time monitoring of Pt(IV) reduction in live cells. Using this advanced reporter, we identified that reactive cysteines in proteins, rather than those in small molecules, predominantly mediate the reduction of Pt(IV) prodrugs.
Shu Chen +10 more
wiley +2 more sources
Interactions between the glycine and glutamate binding sites of the NMDA receptor [PDF]
, 1993 R.A.J. Lester, Gang Tong, CE Jahr
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