Results 181 to 190 of about 2,638,315 (394)

Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Aim The aim of this study was to investigate the therapeutic roles of Tetrandrine (TET) on traumatic brain injury (TBI) and the underlying mechanism. Method Traumatic injury model of hippocampal neurons and TBI mouse model were established to evaluate the therapeutic effects.
Huan Liu, Shiqing He, Chong Li, Jianpeng Wang, Qin Zou, Yongshi Liao, Rui Chen   +6 more
wiley   +1 more source

Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex

Frontiers in Pharmacology
The synapses between parallel fibers and Purkinje cells play a pivotal role in cerebellar function. They are intricately governed by a variety of presynaptic receptors, notably by type 4 metabotropic glutamate (mGlu4) receptors and type 1 adenosine (A1 ...
Simon Bossi, Hervé Daniel, Heather McLean   +2 more
doaj   +1 more source

Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4 [PDF]

, 1993
Yasuto Tanabe, Akihiro Nomura, Masayuki Masu, Ryuichi Shigemoto, Noboru Mizuno, Shigetada Nakanishi   +5 more
openalex   +1 more source

Structural insights into the activation of metabotropic glutamate receptors

Nature, 2019
A. Koehl, Hongli Hu, D. Feng, Bingfa Sun, Yan Zhang, M. J. Robertson, M. Chu, T. S. Kobilka, T. Laeremans, J. Steyaert, Jeffrey Tarrasch, S. Dutta, R. Fonseca, W. Weis, J. M. Mathiesen, G. Skiniotis, B. Kobilka   +16 more
semanticscholar   +1 more source

Chromosome‐Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology

Advanced Science, EarlyView.
The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi, Pan Duan, Mengmeng Zhu, Rong Zhang, Zihua Zhao, Xin Nie, Hanhou He, Li Hou, Xianhui Wang   +8 more
wiley   +1 more source

Quantitative electroencephalographic analysis of delirium tremens development following alcohol‐withdrawal seizure based on a small number of male cases

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Considering the complications related to alcohol withdrawal syndrome (AWS) such as seizure, delirium tremens and cardiac arrhythmia, it is important to identify the risk of delirium tremens (DT) following AWS and enhance preventive strategies. We observed the characteristics of quantitative electroencephalography in patients with AWS, specifically who ...
Jee‐Eun Yoon, Heejung Mo, Dong Wook Kim, Hee‐Jin Im   +3 more
wiley   +1 more source

Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration [PDF]

, 1993
DM Hartley, MC Kurth, L Bjerkness, JH Weiss, DW Choi   +4 more
openalex   +1 more source

Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions

Advanced Science, EarlyView.
The study investigates Deoxynivalenol (DON) effects on feeding and emotions, focusing on the central amygdala (CeA). Acute DON exposure reduces food intake and alters behavior, linked to CeAGABA neuron activity and PVT‐CeA connectivity. Manipulating CeAGABA neurons and using SCN10A antagonist A‐803467 alleviate DON's effects, offering potential ...
Liu‐Nan Yang, Mingmeng Tang, Andreas K. Nüssler, Liegang Liu, Wei Yang   +4 more
wiley   +1 more source

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem, Mohammed A Alsahli, Ahmad Almatroudi, Faris Alrumaihi, Fahd Khaleefah Alkhaleefah, Arshad Husain Rahmani, Amjad Ali Khan   +6 more
wiley   +1 more source

Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: an in situ hybridization study [PDF]

, 1994
LK Friedman, Domenico E. Pellegrini‐Giampietro, EF Sperber, MV Bennett, SL Moshe, RS Zukin   +5 more
openalex   +1 more source