Results 281 to 290 of about 2,536,478 (357)

An Alternative Mechanistic Paradigm for the Electrochemical C‐Terminal Decarboxylation of Peptides

ChemElectroChem, EarlyView.
Chemoselectivity in electrochemical oxidations is largely influenced by oxidation potential which represents a challenge for selectively oxidizing higher potential functional groups in complex substrates. Herein, a molecular binding strategy that selectively oxidizes the C‐terminal acid of a model peptide containing an electron‐rich tyrosine residue by
Adam J. Sowers, Kevin D. Moeller, Kim S. Halskov   +2 more
wiley   +1 more source

Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis

ChemistryEurope, EarlyView.
This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
wiley   +1 more source

Synthesis and 64Cu‐Radiolabeling Strategies of Small Organic Radioconjugates Based on the AMD070 Scaffold

ChemMedChem, EarlyView.
Two novel 64Cu‐radioconjugates have been prepared, based on the AMD070 scaffold as a targeting unit and cyclam‐based te1pa chelator, for future applications in positron emission tomography imaging. Synthesis of ligands and their 64Cu‐radiolabeling are described herein.
Marie M. Le Roy, Patricia Le Saëc, Michel Chérel, Alain Faivre‐Chauvet, Thibault Troadec, Raphaël Tripier   +5 more
wiley   +1 more source

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport. [PDF]

J Neurochem
Lee P, Kim J, Choi IY, Pal R, Hui D, Marcario JK, Michaelis ML, Michaelis EK.   +7 more
europepmc   +1 more source

Effects of Hydrocodone Overdose and Ceftriaxone on Astrocytic Glutamate Transporters and Glutamate Receptors, and Associated Signaling in Nucleus Accumbens as well as Locomotor Activity in C57/BL Mice. [PDF]

Brain Sci
Wong W, Sari Y.
europepmc   +1 more source

Correction to: Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid. [PDF]

Psychopharmacology (Berl)
D'Antoni S, Schiavi S, Buzzelli V, Giuffrida S, Feo A, Ascone F, Busceti CL, Nicoletti F, Trezza V, Catania MV.   +9 more
europepmc   +1 more source

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Cloned glutamate receptors.

Annual Review of Neuroscience, 1994
The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian ...
M. Hollmann, S. Heinemann
semanticscholar   +4 more sources

Metabotropic glutamate receptors

Cell and Tissue Research, 2006
Metabotropic glutamate receptors (mGlus) are a family of G-protein-coupled receptors activated by the neurotransmitter glutamate. Molecular cloning has revealed eight different subtypes (mGlu1-8) with distinct molecular and pharmacological properties. Multiplicity in this receptor family is further generated through alternative splicing. mGlus activate
Ferraguti F., Shigemoto R.
openaire   +3 more sources