Results 291 to 300 of about 2,596,775 (326)

Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4

Nature, 2021
Shuling Lin, Shuo Han, Xiao-qing Cai, Q. Tan, Kexiu Zhou, Dejian Wang, Xinwei Wang, Juan Du, C. Yi, Xiaojing Chu, A. Dai, Yan Zhou, Yan Chen, Yu Zhou, Hong Liu, Jianfeng Liu, Dehua Yang, Ming-Wei Wang, Qiang Zhao, Beili Wu   +19 more
semanticscholar   +1 more source

Structure of Glutamate Receptors

Current Drug Targets, 2007
Glutamate receptors mediate a vast array of processes in plants, animals and bacteria. In particular, the ionotropic glutamate receptors (iGluRs) are the most abundant excitatory neurotransmitter receptors in the mammalian central nervous system. Because these proteins are constructed from distinct folding domains, most of which can be traced to ...
Robert E, Oswald, Ahmed, Ahmed, Michael K, Fenwick, Adrienne P, Loh   +3 more
openaire   +2 more sources

Glutamate receptors and pain

Seminars in Cell & Developmental Biology, 2006
Pain is an important survival and protection mechanism for animals. However, chronic/persistent pain may be differentiated from normal physiological pain in that it confers no obvious advantage. An accumulating body of pharmacological, electrophysiological, and behavioral evidence is emerging in support of the notion that glutamate receptors play a ...
David, Bleakman, Andrew, Alt, Eric S, Nisenbaum   +2 more
openaire   +2 more sources

Neurotransmitters: Elusive glutamate receptors

Current Biology, 1994
Kainate-preferring glutamate receptors appear to be abundant in the central nervous system. We have recently begun to understand their properties, but their functions remain to be described.
D, Feldmeyer, S, Cull-Candy
openaire   +2 more sources

Glutamate receptor channel signatures

Trends in Pharmacological Sciences, 2001
Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in the conserved channel pore. The predicted sequences of the putative glutamate receptor subunits revealed a distinct channel pore signature for each ...
Sprengel, R., Aronoff, R., Völkner, M., Schmitt, B., Mosbach, R., Kuner, T.   +5 more
openaire   +3 more sources

Inhibitory glutamate receptor channels

Molecular Neurobiology, 1996
Inhibitory glutamate receptors (IGluRs) are a family of ion channel proteins closely related to ionotropic glycine and gamma-aminobutyric acid (GABA) receptors; They are gated directly by glutamate; the open channel is permeable to chloride and sometimes potassium. Physiologically and pharmacologically, IGluRs most closely resemble GABA receptors; they
openaire   +2 more sources

Pharmacology and functions of metabotropic glutamate receptors.

Annual Review of Pharmacology and Toxicology, 1997
Conn Pj, J. Pin
semanticscholar   +1 more source

Pharmacology of the glutamate receptor

Progress in Neurobiology, 1988
The history of pharmacological examinations of glutamate receptor agonists such as kainic acid, quisqualic acid, acromelic acid, L-CCG-I, DCG-IV and L-F2CCG-I was described. Kainic acid is one of the most potent excitants in the mammalian central neurons, and its powerful excitatory actions gave rise to the excitotoxic concept that glutamate destroys ...
openaire   +3 more sources

Molecular diversity of glutamate receptors and implications for brain function.

Science, 1992
S. Nakanishi
semanticscholar   +1 more source

Metabotropic glutamate receptors

Pharmacology Biochemistry and Behavior, 2002
openaire   +2 more sources