Results 301 to 310 of about 2,536,478 (357)

A family of AMPA-selective glutamate receptors.

Science, 1990
Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library.
K. Keinänen, W. Wisden, B. Sommer, P. Werner, A. Herb, T. Verdoorn, B. Sakmann, P. Seeburg   +7 more
semanticscholar   +1 more source

Metabotropic Glutamate Receptors and Neurodegeneration

2004
Metabotropic glutamate (mGlu) receptors, which exert a modulatory effect on excitatory synaptic transmission, are considered as potential targets for neuroprotective drugs and the advent of potent and centrally available subtype-selective ligands has lead to an extensive investigation of the role of individual mGlu receptor subtypes in ...
BRUNO, Valeria Maria Gloria, BATTAGLIA, Giuseppe, A. Copani, G. Casabona, M. Storto, V. D. Giorgi, R. Ngomba, NICOLETTI, Ferdinando   +7 more
openaire   +6 more sources

Glutamate Receptor Ligands

2007
Glutamate acts through a variety of receptors to modulate neurotransmission and neuronal excitability. Glutamate plays a critical role in neuroplasticity as well as in nervous system dysfunctions and disorders. Hyperfunction or dysfunction of glutamatergic neurotransmission also represents a key mechanism of pain-related plastic changes in the central ...
openaire   +3 more sources

Glutamate receptors and new glutamate agonists

Trends in Pharmacological Sciences, 1983
Abstract A variety of naturally occurring and synthetic analogues of the putative excitatory amino acid neurotransmittersl-glutamic acid (l-GLU) andl-aspartec acid (l-ASP) are powerful neuroexcitatory and neurotoxic agents. These effects appear to be mediated primarily by the central receptors normally operated byl-GLU and/orl-ASP.
Tage Honore, Povl Krogsgaard-Larsen
openaire   +2 more sources

Pharmacology of Glutamate Receptors

2002
Glutamate is the principal excitatory neurotransmitter in the central nervous system, playing an essential role in virtually every brain system and their associated behavioral functions. Modulation of glutamate-mediated neurotransmission is a major way in which the function of the nervous system is modified in response to experience (see Chapter 4 ...
Rafal Kaminski, Michael A. Rogawski, Jeffrey M. Witkin   +2 more
openaire   +2 more sources

Mammalian ionotropic glutamate receptors

Current Opinion in Neurobiology, 1993
Exciting new milestones in glutamate receptor (GluR) channel research include the following: the cloning of N-methyl-D-aspartate (NMDA) receptors; delineation of molecular determinants for ion flow through glutamate-gated channels; the discovery that Ca2+ permeability of non-NMDA receptor channels is determined by RNA editing; the construction of ...
Wisden, W., Seeburg, P.
openaire   +4 more sources

Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4

Nature, 2021
Shuling Lin, Shuo Han, Xiao-qing Cai, Q. Tan, Kexiu Zhou, Dejian Wang, Xinwei Wang, Juan Du, C. Yi, Xiaojing Chu, A. Dai, Yan Zhou, Yan Chen, Yu Zhou, Hong Liu, Jianfeng Liu, Dehua Yang, Ming-Wei Wang, Qiang Zhao, Beili Wu   +19 more
semanticscholar   +1 more source

Glutamate and Glutamate Receptors in the Vertebrate Retina

2023
Book chapter published in: Kolb, H., Fernandez, E., Nelson, R., Webvision: The Organization of the Retina and Visual System [Internet].
openaire   +1 more source

Oxidative stress, glutamate, and neurodegenerative disorders.

Science, 1993
There is an increasing amount of experimental evidence that oxidative stress is a causal, or at least an ancillary, factor in the neuropathology of several adult neurodegenerative disorders, as well as in stroke, trauma, and seizures.
J. Coyle, P. Puttfarcken
semanticscholar   +1 more source

Molecular biology of glutamate receptors

Progress in Neurobiology, 1994
The ligand-gated receptors for L-glutamate play a central role in acute neuronal degeneration. Recently cDNAs have been isolated for subunits of several glutamate receptor subtypes. By sequence homology all these subunits clearly belong to one large gene family.
Schöpfer, R., Monyer, H., Sommer, B., Wisden, W., Sprengel, R., Kuner, T., Lomeli, H., Herb, A., Köhler, M., Burnashev, N., Günther, W., Ruppersberg, J., Seeburg, P.   +12 more
openaire   +4 more sources