Results 301 to 310 of about 2,726,442 (336)
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Pharmacology of the glutamate receptor
Progress in Neurobiology, 1988The history of pharmacological examinations of glutamate receptor agonists such as kainic acid, quisqualic acid, acromelic acid, L-CCG-I, DCG-IV and L-F2CCG-I was described. Kainic acid is one of the most potent excitants in the mammalian central neurons, and its powerful excitatory actions gave rise to the excitotoxic concept that glutamate destroys ...
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Ionotropic glutamate receptors
Current Opinion in Chemical Biology, 1999The glutamate-binding sites of ionotropic glutamate receptors are formed from two extracellular domains of a single subunit. Conformational changes induced by agonist binding produce mechanical processes that are translated into ion gating and receptor desensitization.
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Current Opinion in Neurobiology, 1994
The past year has seen significant advances in matching the actions of recombinant glutamate receptors with the actions of native receptors, and in mapping their distribution and regulation. The discovery of a novel RNA editing mechanism for AMPA receptors and a revised view of the transmembrane topology of the NMDA receptor subunit, NR1, are ...
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The past year has seen significant advances in matching the actions of recombinant glutamate receptors with the actions of native receptors, and in mapping their distribution and regulation. The discovery of a novel RNA editing mechanism for AMPA receptors and a revised view of the transmembrane topology of the NMDA receptor subunit, NR1, are ...
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Biological Psychiatry, 2013
Recent compelling evidence has suggested that the glutamate system is a primary mediator of psychiatric pathology and also a target for rapid-acting antidepressants. Clinical research in mood and anxiety disorders has shown alterations in levels, clearance, and metabolism of glutamate and consistent volumetric changes in brain areas where glutamate ...
L. Musazzi +3 more
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Recent compelling evidence has suggested that the glutamate system is a primary mediator of psychiatric pathology and also a target for rapid-acting antidepressants. Clinical research in mood and anxiety disorders has shown alterations in levels, clearance, and metabolism of glutamate and consistent volumetric changes in brain areas where glutamate ...
L. Musazzi +3 more
semanticscholar +3 more sources
2007
Glutamate acts through a variety of receptors to modulate neurotransmission and neuronal excitability. Glutamate plays a critical role in neuroplasticity as well as in nervous system dysfunctions and disorders. Hyperfunction or dysfunction of glutamatergic neurotransmission also represents a key mechanism of pain-related plastic changes in the central ...
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Glutamate acts through a variety of receptors to modulate neurotransmission and neuronal excitability. Glutamate plays a critical role in neuroplasticity as well as in nervous system dysfunctions and disorders. Hyperfunction or dysfunction of glutamatergic neurotransmission also represents a key mechanism of pain-related plastic changes in the central ...
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Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4
Nature, 2021Shuling Lin +19 more
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Glutamate Receptors in Taste Receptor Cells
2007Glutamate plays a double role in the physiology of TRCs. As a free-occurring component of some foodstuff, glutamate is detected by TRCs and conveys information about the presence of protein-rich source. As a substance released by TRC and/or nerve endings, it is involved in cell-to-cell communication at chemical synapses in taste organs.
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Glutamate receptors and new glutamate agonists
Trends in Pharmacological Sciences, 1983Abstract A variety of naturally occurring and synthetic analogues of the putative excitatory amino acid neurotransmittersl-glutamic acid (l-GLU) andl-aspartec acid (l-ASP) are powerful neuroexcitatory and neurotoxic agents. These effects appear to be mediated primarily by the central receptors normally operated byl-GLU and/orl-ASP.
Povl Krogsgaard-Larsen, Tage Honore´
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Glutamate and Glutamate Receptors in the Vertebrate Retina
2023Book chapter published in: Kolb, H., Fernandez, E., Nelson, R., Webvision: The Organization of the Retina and Visual System [Internet].
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