Results 31 to 40 of about 314,122 (297)
Glutamate receptor pores [PDF]
The Journal of Physiology, 2014 AbstractGlutamate receptors are ligand‐gated ion channels that mediate fast excitatory synaptic transmission throughout the central nervous system. Functional receptors are homo‐ or heteromeric tetramers with each subunit contributing a re‐entrant pore loop that dips into the membrane from the cytoplasmic side. The pore loops form a narrow constriction
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mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]
, 2018 Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua +9 more
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Metabotropic glutamate receptors in cancer [PDF]
Neuropharmacology, 2017 Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in human malignancies in addition to synaptic transmission. Somatic cell homeostasis presents intriguing possibilities of mGluRs and glutamate signaling as novel targets for human cancers.
Lumeng J, Yu +3 more
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Molecular Pain, 2020 Temporomandibular joint disorder is a common chronic craniofacial pain condition, often involving persistent, widespread craniofacial muscle pain.
Man-Kyo Chung, Jin Y Ro
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Morphological plasticity of astroglia: Understanding synaptic microenvironment [PDF]
, 2015 Memory formation in the brain is thought to rely on the remodeling of synaptic connections which eventually results in neural network rewiring. This remodeling is likely to involve ultrathin astroglial protrusions which often occur in the immediate ...
Heller, JP, Rusakov, DA
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Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2013 The authors examined 92 patients with gliomas in the cerebral hemispheres. The immunoenzyme method was used for semiquantitative assay of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate.
V. N. Ochkolyas +3 more
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Astroglial Glutamate Signaling and Uptake in the Hippocampus
Frontiers in Molecular Neuroscience, 2018 Astrocytes have long been regarded as essentially unexcitable cells that do not contribute to active signaling and information processing in the brain. Contrary to this classical view, it is now firmly established that astrocytes can specifically respond
Christine R. Rose +7 more
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Frontiers in Neuroscience, 2021 Glutamate signalling is an essential aspect of neuronal communication involving many different glutamate receptors, and underlies the processes of memory, learning and synaptic plasticity.
Richard Fairless +4 more
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Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight [PDF]
, 2019 FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR.
Deng, Ran +14 more
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The DLGAP family: neuronal expression, function and role in brain disorders
Molecular Brain, 2017 The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses. Glutamate is released from the presynaptic membrane into the synaptic cleft.
Andreas H. Rasmussen +2 more
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