Results 41 to 50 of about 83,270 (165)

Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure

open access: yesScientific Reports, 2021
Methamphetamine (METH) is a highly addictive psychostimulant that causes long-lasting effects in the brain and increases the risk of developing neurodegenerative diseases. The cellular and molecular effects of METH in the brain are functionally linked to
Bobby Jones   +9 more
doaj   +1 more source

Purification and properties of glutamate synthase and glutamate dehydrogenase from Bacillus megaterium [PDF]

open access: yesBiochemical Journal, 1978
Bacillus megaterium N.C.T.C. no. 10342 exhibits glutamate synthetase (EC 2.6.1.53) and glutamate dehydrogenase (EC 1.4.1.4) activities. Concentrations of glutamate synthase were high when the bacteria were grown on 3mM-NH4Cl and low when they were grown on 100mM-NH4Cl, whereas glutamate dehydrogenase concentrations were higher when the bacteria were ...
I A, Hemmilä, P I, Mäntsälä
openaire   +2 more sources

Decreased glutamate transport in acivicin resistant Leishmania tarentolae.

open access: yesPLoS Neglected Tropical Diseases, 2021
Studies of drug resistance in the protozoan parasites of the genus Leishmania have been helpful in revealing biochemical pathways as potential drug targets.
Gaétan Roy   +3 more
doaj   +1 more source

Metabolic rewiring enables ammonium assimilation via a non‐canonical fumarate‐based pathway

open access: yesMicrobial Biotechnology
Glutamate serves as the major cellular amino group donor. In Bacillus subtilis, glutamate is synthesized by the combined action of the glutamine synthetase and the glutamate synthase (GOGAT).
Mohammad Saba Yousef Mardoukhi   +8 more
doaj   +1 more source

Role of carglumic acid in the treatment of acute hyperammonemia due to N-acetylglutamate synthase deficiency

open access: yesTherapeutics and Clinical Risk Management, 2011
Johannes HäberleKinderspital Zürich, Abteilung Stoffwechsel, Zürich, SwitzerlandAbstract: N-acetylglutamate synthase (NAGS) deficiency is a rare inborn error of metabolism affecting ammonia detoxification in the urea cycle. The
Häberle J
doaj  

Salicylic acid mediated changes in growth, photosynthesis, nitrogen metabolism and antioxidant defense system in Cicer arietinum L.

open access: yesPlant, Soil and Environment, 2012
The present study reveals that the foliar application of salicylic acid (SA), irrespective of the concentration used, generated an increase of dry mass per plant, nodule dry mass and leghemoglobin content in chickpea plants.
Q. Hayat   +3 more
doaj   +1 more source

Rhizobium etli Mutant Modulates Carbon and Nitrogen Metabolism in Phaseolus vulgaris Nodules

open access: yesMolecular Plant-Microbe Interactions, 2002
The aim of this study was to evaluate the biochemical events in root nodules which lead to increased yield when bean is inoculated with a Rhizobium etli mutant (CFN037) having increased respiratory capacity. CFN037-inoculated plants had 22% more nitrogen
Sonia Silvente   +5 more
doaj   +1 more source

Metabolic engineering of Escherichia coli for the biosynthesis of 2-pyrrolidone

open access: yesMetabolic Engineering Communications, 2016
2-Pyrrolidone is a valuable bulk chemical with myriad applications as a solvent, polymer precursor and active pharmaceutical intermediate. A novel 2-pyrrolidone synthase, ORF27, from Streptomyces aizunensis was identified to catalyze the ring closing ...
Jingwei Zhang   +5 more
doaj   +1 more source

Anoxia-induced hippocampal LTP is regeneratively produced by glutamate and nitric oxide from the neuro-glial-endothelial axis

open access: yesiScience
Summary: Transient anoxia causes amnesia and neuronal death. This is attributed to enhanced glutamate release and modeled as anoxia-induced long-term potentiation (aLTP).
Han-Ying Wang   +6 more
doaj   +1 more source

Structural basis of proton translocation and force generation in mitochondrial ATP synthase

open access: yeseLife, 2017
ATP synthases produce ATP by rotary catalysis, powered by the electrochemical proton gradient across the membrane. Understanding this fundamental process requires an atomic model of the proton pathway.
Niklas Klusch   +4 more
doaj   +1 more source

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