Results 1 to 10 of about 200,780 (234)
Role of glutamine synthetase in angiogenesis beyond glutamine synthesis [PDF]
Nature, 2018 Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows negligible glutamine-synthesizing activity in these cells at physiological glutamine levels.
Charlotte Dubois +2 more
exaly +9 more sources
Novel aspects of glutamine synthetase in ammonia homeostasis [PDF]
Neurochemistry International, 2020 Elevated blood ammonia (hyperammonemia) is believed to be a major contributor to the neurological sequelae following severe liver disease. Ammonia is cleared via two main mechanisms, the urea cycle pathway and the glutamine synthetase reaction.
Bjørnar Hassel, Tore Eid, Yun Zhou
exaly +3 more sources
Glutamine Synthetase: Localization Dictates Outcome [PDF]
Genes, 2018 Glutamine synthetase (GS) is the adenosine triphosphate (ATP)-dependent enzyme that catalyses the synthesis of glutamine by condensing ammonium to glutamate.
Alessandra Castegna, Alessio Menga
semanticscholar +8 more sources
Glutamine Synthetase as a Therapeutic Target for Cancer Treatment
International Journal of Molecular Sciences, 2021 The significance of glutamine in cancer metabolism has been extensively studied. Cancer cells consume an excessive amount of glutamine to facilitate rapid proliferation.
Dong Hoon Lee, So Hee Kwon, Gowoon Kim
exaly +2 more sources
Astrocytes and Glutamine Synthetase in Epileptogenesis [PDF]
Journal of Neuroscience Research, 2018 The cellular, molecular, and metabolic mechanisms that underlie the development of mesial temporal lobe epilepsy are incompletely understood. Here we review the role of astrocytes in epilepsy development (a.k.a.
T. Eid +3 more
semanticscholar +3 more sources
Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase
Cell Reports, 2019 Summary: Glutamate has been implicated in a wide range of brain pathologies and is thought to be metabolized via the astrocyte-specific enzyme glutamine synthetase (GS).
Wendy Xin +7 more
doaj +2 more sources
M. mazei glutamine synthetase and glutamine synthetase-GlnK1 structures reveal enzyme regulation by oligomer modulation [PDF]
Nature Communications, 2023 Glutamine synthetases (GS) play central roles in cellular nitrogen assimilation. Although GS active-site formation requires the oligomerization of just two GS subunits, all GS form large, multi-oligomeric machines.
Maria A. Schumacher +4 more
doaj +2 more sources
Expression of Glutamine Synthetase in Macrophages [PDF]
Journal of Histochemistry & Cytochemistry, 2000 We studied the expression of glutamine synthetase in liver macrophages (Kupffer cells, KCs) in situ and in culture. Glutamine synthetase was detectable at the mRNA and protein level in freshly isolated and short-term-cultured rat liver macrophages. Enzyme activity and protein content were about 9% of that in liver parenchymal cells.
J G, Bode +3 more
openaire +4 more sources
Cell Reports, 2019 Summary: Radiation resistance is a critical problem in radiotherapy for cancer. Radiation kills tumor cells mainly through causing DNA damage. Thus, efficiency of DNA damage repair is one of the most important factors that limits radiotherapy efficacy ...
Shujun Fu +15 more
doaj +2 more sources
Loss of Müller cell glutamine synthetase immunoreactivity is associated with neuronal changes in late-stage retinal degeneration [PDF]
Frontiers in Neuroanatomy, 2023 IntroductionA hallmark of photoreceptor degenerations is progressive, aberrant remodeling of the surviving retinal neurons and glia following photoreceptor loss.
Hallur Reynisson +7 more
doaj +2 more sources