Results 21 to 30 of about 200,780 (234)

Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform. [PDF]

PLoS ONE, 2017
Glutamine synthetase is a ubiquitous central enzyme in nitrogen metabolism that is controlled by up to four regulatory mechanisms, including adenylylation of some or all of the twelve subunits by adenylyl transferase.
A Theron, R L Roth, H Hoppe, C Parkinson, C W van der Westhuyzen, S Stoychev, I Wiid, R D Pietersen, B Baker, C P Kenyon   +9 more
doaj   +1 more source

Glutamine Synthetase Sensitivity to Oxidative Modification during Nutrient Starvation in Prochlorococcus marinus PCC 9511. [PDF]

PLoS ONE, 2015
Glutamine synthetase plays a key role in nitrogen metabolism, thus the fine regulation of this enzyme in Prochlorococcus, which is especially important in the oligotrophic oceans where this marine cyanobacterium thrives.
Guadalupe Gómez-Baena, María Agustina Domínguez-Martín, Robert P Donaldson, José Manuel García-Fernández, Jesús Diez   +4 more
doaj   +1 more source

Licensing instead of fueling: Glutamine synthetase promotes mitotic progression via a non-metabolic mechanism

Visualized Cancer Medicine, 2023
A recent report published in Nature Metabolism identified that glutamine synthetase (GS), the only enzyme in mammals to produce glutamine from glutamate, can directly control cancer cell mitosis by governing the APC/C complex via a metabolism-independent
Zhao Jiang-Sha, Yang Jing, Lu Zhimin, Feng Yu-Xiong   +3 more
doaj   +1 more source

Regulation of synthesis of glutamine synthetase by adenylylated glutamine synthetase. [PDF]

Proceedings of the National Academy of Sciences, 1975
We have examined three mutants of Klebsiella aerogenes whose genetic lesions (glnB, glnD, and glnE) are in loci unlinked to the structural gene for glutamine sythetase (glnA) and in which the control of both the level and state of adenylylation of glutamine synthetase is altered. Each mutation alters a different component of the adenylylation system of
F, Foor, K A, Janssen, B, Magasanik
openaire   +2 more sources

Investigating the role of GLUL as a survival factor in cellular adaptation to glutamine depletion via targeted stable isotope resolved metabolomics

Frontiers in Molecular Biosciences, 2022
Cellular glutamine synthesis is thought to be an important resistance factor in protecting cells from nutrient deprivation and may also contribute to drug resistance.
Șafak Bayram, Yasmin Sophiya Razzaque, Sabrina Geisberger, Matthias Pietzke, Matthias Pietzke, Susanne Fürst, Susanne Fürst, Carolina Vechiatto, Martin Forbes, Guido Mastrobuoni, Stefan Kempa   +10 more
doaj   +1 more source

Pattern of Different Immunohistochemical Stains in Various Types of Hepatoblastoma

Pakistan Armed Forces Medical Journal, 2022
Objective: To assess the utility of four immunohistochemical stains in the categorization of hepatoblastoma. Study Design: Retrospective longitudinal study.
Hina Maqbool, Sajid Mushtaq, Mudassar Hussain, Umer Nisar Sheikh, Usman Hassan, Saud Sarwar, Maryam Hameed, Mohammad Tariq Mehmood, Asad Hayat Ahmad   +8 more
doaj   +1 more source

Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Pancreatic ductal adenocarcinoma (PDA) is a highly lethal malignancy with no effective therapies. PDA aggressiveness partly stems from its ability to grow within a uniquely dense stroma restricting nutrient access.
Pei-Yun Tsai, Min-Sik Lee, U. Jadhav, Insia Naqvi, Shariq Madha, Ashley Adler, Meeta Mistry, S. Naumenko, C. Lewis, Daniel S. Hitchcock, Frederick R Roberts, Peter DelNero, T. Hank, K. Honselmann, Vicente Morales Oyarvide, M. Mino‐Kenudson, C. Clish, R. Shivdasani, Nada Y. Kalaany   +18 more
semanticscholar   +1 more source

Glutamine synthetase in muscle and kidney [PDF]

Biochemical Journal, 1970
1. Glutamine synthetase activity has been determined in extracts of rat cardiac and skeletal muscle and kidney, after treatment to ensure that the rate of synthesis was proportional to time of incubation and to amount of extract added. The activity was measured by two methods, with hydroxylamine as substrate. 2.
K, Iqbal, J H, Ottaway
openaire   +2 more sources

Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway

Bone Research, 2022
Ammonia plays an important role in cellular metabolism. However, ammonia is considered a toxic product. In bone marrow-derived mesenchymal stem cells, multipotent stem cells with high expression of glutamine synthetase (GS) in bone marrow, ammonia and ...
Yu Liu, Xiangxian Zhang, Wei Wang, Ting Liu, Jun Ren, Siyuan Chen, Tianqi Lu, Yan Tie, Xia Yuan, Fei Mo, Jingyun Yang, Yuquan Wei, Xiawei Wei   +12 more
doaj   +1 more source

Reduced density of glutamine synthetase immunoreactive astrocytes in different cortical areas in major depression but not in bipolar I disorder

Frontiers in Cellular Neuroscience, 2015
There is increasing evidence for disturbances within the glutamate system in patients with affective disorders, which involve disruptions of the glutamate-glutamine- cycle.
Hans-Gert eBernstein, Gabriela eMeyer-Lotz, Henrik eDobrowlny, Jana eBannier, Johann eSteiner, Martin eWalter, Martin eWalter, Bernhard eBogerts   +7 more
doaj   +1 more source