Results 41 to 50 of about 119,068 (185)

Advances in human glutamine-hydrolyzing synthetases and their therapeutic potential

Frontiers in Chemical Biology
Bifunctional enzymes, characterized by their dual active sites, enable efficient chemical conversion and substrate channeling using elegant coupling mechanisms to coordinate the two active sites. In humans, several bifunctional enzymes synthesize de novo
Wen Zhu, Alanya J. Nardone, Lucciano A. Pearce   +2 more
doaj   +1 more source

Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair

Cell Reports, 2019
Summary: Radiation resistance is a critical problem in radiotherapy for cancer. Radiation kills tumor cells mainly through causing DNA damage. Thus, efficiency of DNA damage repair is one of the most important factors that limits radiotherapy efficacy ...
Shujun Fu, Zhi Li, Lanbo Xiao, Wenfeng Hu, Lu Zhang, Bowen Xie, Qin Zhou, Junju He, Yanfang Qiu, Ming Wen, Yanni Peng, Jie Gao, Rong Tan, Yuezhen Deng, Liang Weng, Lun-Quan Sun   +15 more
doaj   +1 more source

Reassimilation of Photorespiratory Ammonium in Lotus japonicus Plants Deficient in Plastidic Glutamine Synthetase. [PDF]

PLoS ONE, 2015
It is well established that the plastidic isoform of glutamine synthetase (GS2) is the enzyme in charge of photorespiratory ammonium reassimilation in plants.
Carmen M Pérez-Delgado, Margarita García-Calderón, Antonio J Márquez, Marco Betti   +3 more
doaj   +1 more source

Glutamine synthetase 2 is not essential for biosynthesis of compatible solutes in Halobacillus halophilus

Frontiers in Microbiology, 2014
Halobacillus halophilus, a moderately halophilic bacterium isolated from salt marshes, produces various compatible solutes to cope with osmotic stress. Glutamate and glutamine are dominant compatible solutes at mild salinities.
Anna eShiyan, Melanie eThompson, Saskia eKöcher, Michaela eTausendschön, Helena eSantos, Inga eHänelt, Volker eMüller   +6 more
doaj   +1 more source

The differential expression of the genes encoding glutamine synthetase in developing root modules [PDF]

, 1990
Glutamine synthetase (GS) is one of the key enzymes involved in the assimilation of ammonia into organic nitrogen in plants. It is important in legume root nodules where ammonia, produced by the Rhizobium-legume symbiosis, is converted to organic ...
Teverson, Rachel
core  

The role of cytosolic glutamine synthetase in wheat

, 2001
The definitive version is available at www.blackwell-synergy.comThe role of glutamine synthetase (GS; EC 6.3.1.2) was studied in wheat. GS isoforms were separated by HPLC and the two major leaf isoforms (cytosolic GS1 and chloroplastic GS2) were found to
Rong, H. L., Massiah, A. J., Leigh, R., Massiah, A., Rong, H., Wallsgrove, R. M., Habash, D., Wallsgrove, R., Habash, D. Z., Leigh, R. A.   +9 more
core   +1 more source

Nitrogen metabolism in a grapevine in vitro system

OENO One, 2002
Ammonium, nitrate, nitrite, protein and individual and total amino acid contents were determined in grapevine (cv Sauvignon) cultured in vitro. The enzyme activities of nitrate and nitrite reductases, glutamine synthetase, glutamate synthetase and ...
Nuria Llorens, Lluís Arola, Cinta Bladé, Albert Mas   +3 more
doaj   +1 more source

Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment

Frontiers in Oncology, 2023
IntroductionGlutamine deficiency is a well-known feature of the tumor environment. Here we analyzed the impact of glutamine deprivation on human myeloid cell survival and function.MethodsDifferent types of myeloid cells were cultured in the absence or ...
Robert Schoeppe, Nathalie Babl, Sonja-Maria Decking, Sonja-Maria Decking, Sonja-Maria Decking, Gabriele Schönhammer, Andreas Siegmund, Andreas Siegmund, Christina Bruss, Christina Bruss, Katja Dettmer, Peter J. Oefner, Linus Frick, Anna Weigert, Jonathan Jantsch, Wolfgang Herr, Michael Rehli, Michael Rehli, Kathrin Renner, Kathrin Renner, Marina Kreutz, Marina Kreutz   +21 more
doaj   +1 more source

Parenteral glutamine in critical illness : just what the gut needs [PDF]

, 2012
The role of glutamine as a metabolic fuel for the starving intestines, its capacity to limit bacterial translocation, lung sepsis and a pro-inflammatory cytokine response are reviewed in the context of uncertainities regarding current recommendations for
Pullicino, Edgar
core  

The Unexpected Essentiality of glnA2 in Mycobacterium smegmatis Is Salvaged by Overexpression of the Global Nitrogen Regulator glnR, but Not by L-, D- or Iso-Glutamine

Frontiers in Microbiology, 2018
Nitrogen metabolism plays a central role in the physiology of microorganisms, and Glutamine Synthetase (GS) genes are present in virtually all bacteria. In M.
Nadya Rakovitsky, Michal Bar Oz, Karin Goldberg, Simon Gibbons, Oren Zimhony, Oren Zimhony, Daniel Barkan   +6 more
doaj   +1 more source