Results 61 to 70 of about 119,068 (185)

Glutamine synthetase inhibitors in cancer [PDF]

, 2017
Glutamine synthetase inhibitors in ...
Alessandra Castegna, Alessio Menga, Massimiliano Mazzone, Erika Mariana Palmieri   +3 more
core  

Male proband with intractable seizures and a de novo start-codon-disrupting variant in GLUL

HGG Advances
Summary: Bi-allelic variants in GLUL, encoding glutamine synthetase and responsible for the conversion of glutamate to glutamine, are associated with a severe recessive disease due to glutamine deficiency.
Elizabeth Carbonell, Sarah L. Stenton, Vijay S. Ganesh, Jialan Ma, Grace E. VanNoy, Lynn Pais, John N. Gaitanis, Melanie C. O’Leary, Heidi L. Rehm, Anne O’Donnell-Luria   +9 more
doaj   +1 more source

Neural control of glutamine synthetase activity in rat skeletal muscles

, 1990
The mechanism of glutamine synthetase induction in rat skeletal muscle after denervation or limb immobilization was investigated. Adult male rats were subjected to midthigh section of the sciatic nerve.
C. Banner, B. Feng, J. W. Thomas, S. R. Max, M. Konagaya, J. Mill, Y. Konagaya   +6 more
core   +1 more source

Nitrogen assimilation in Citrus based on CitEST data mining

Genetics and Molecular Biology, 2007
Assimilation of nitrate and ammonium are vital procedures for plant development and growth. From these primary paths of inorganic nitrogen assimilation, this metabolism integrates diverse paths for biosynthesis of macromolecules, such as amino acids and ...
Ester Wickert, Jackson Marcondes, Manoel Victor Lemos, Eliana G.M. Lemos   +3 more
doaj   +1 more source

Circumstantial evidence for a role of glutamine-synthetase in suicide

, 2011
Suicide occurs during depression, schizophrenia and epilepsy. A common denominator of these disorders is the presence of a brain inflammation. Inflammatory cytokines affect function and expression of the glial enzyme glutamine synthetase and post mortem ...
Kalkman, Hans O., Hans O. Kalkman
core   +1 more source

Glutamine synthetase: glial localization in brain

, 1977
Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium
Bell, K P, Norenberg, M D, Martinez-Hernandez, A   +2 more
core   +1 more source

Glutamine replenishment and ammonia removal in hybridoma cell cultures via immobilized glutamine synthetase

, 1999
Hybridoma cells utilize glutamine as their primary nitrogen source and excrete ammonia as a metabolic waste product. This ammonia can quickly accumulate to toxic levels in hybridoma culture media, and can severely reduce monoclonal antibody production ...
Okeson, Carl D.
core   +4 more sources

Metabolic regulation of ammonia emission in different senescence phenotypes of Nicotiana tabacum

Biologia Plantarum, 2016
In order to reveal the character of ammonia emission in senescent tobacco (Nicotiana tabacum), the content of NH4 +, total nitrogen, and soluble protein, and the activities of nitrogen metabolism-related enzymes were measured in leaves of a quick-leaf ...
Y. J. Wu, T. Z. Yang, Y. Y. Song, X. Q. Zhang, S. X. Xu, G. Xue, X. X. Xing   +6 more
doaj   +1 more source

Specificities of Human Hepatocellular Carcinoma Developed on Non-Alcoholic Fatty Liver Disease in Absence of Cirrhosis Revealed by Tissue Extracts 1H-NMR Spectroscopy

Metabolites, 2017
There is a rising incidence of non-alcoholic fatty liver disease (NAFLD) as well as of the frequency of Hepato-Cellular Carcinoma (HCC) associated with NAFLD.
Camille Teilhet, Daniel Morvan, Juliette Joubert-Zakeyh, Anne-Sophie Biesse, Bruno Pereira, Sylvie Massoulier, Pierre Dechelotte, Denis Pezet, Emmanuel Buc, Géraldine Lamblin, Michel Peoc’h, Jack Porcheron, Marie-Paule Vasson, Armando Abergel, Aicha Demidem   +14 more
doaj   +1 more source

Congenital Glutamine Deficiency with Glutamine Synthetase Mutations [PDF]

New England Journal of Medicine, 2006
Rose, Christopher, Jalan, Rajiv
openaire   +2 more sources