Results 51 to 60 of about 200,780 (234)
Abnormalities in Glutamate Metabolism and Excitotoxicity in the Retinal Diseases
Scientifica, 2013 In the physiological condition, glutamate acts as an excitatory neurotransmitter in the retina. However, excessive glutamate can be toxic to retinal neurons by overstimulation of the glutamate receptors.
Makoto Ishikawa
doaj +1 more source
The Regulation of Glutamine Transport and Glutamine Synthetase in Salmonella typhimurium [PDF]
Journal of General Microbiology, 1976 Transport of glutamine by the high-affinity transport system is regulated by the nitrogen status of the medium. With high concentrations of ammonia, transport is repressed; whereas with Casamino acids, transport is elevated, showing behaviour similar to glutamine synthetase.
P R, Betteridge, P D, Ayling
openaire +2 more sources
Effect of chilling and acclimation on the activity of glutamine synthetase isoforms in maize seedlings [PDF]
Archives of Biological Sciences, 2007 Effects of chilling and acclimation on the activity of cytosolic (GS1) and plastidic (GS2) isoforms of glutamine synthetase (E.C. 6.3.1.2) were studied in chilling-sensitive and acclimation-responsive maize inbred G50.
Simonović Ana D., Anderson M.D.
doaj +1 more source
Brazilian Archives of Biology and Technology, 2006 The arginase tissue distribution, the biochemical properties of the argininolytic system and the subcellular localization of the enzymes carbamoylphosphate synthetase, ornithinecarbamoyl transferase, glutamine synthetase and arginase in Antarctic fish, N.
Edson Rodrigues +2 more
doaj +1 more source
Cell Metabolism, 2016 SUMMARY Reactive stromal cells are an integral part of tumor microenvironment (TME) and interact with cancer cells to regulate their growth. Although targeting stromal cells could be a viable therapy to regulate the communication between TME and cancer ...
Lifeng Yang +28 more
semanticscholar +1 more source
Molecules and Cells, 2016 SUMMARY Cereblon (CRBN), a substrate receptor for the cullin–RING ubiquitin ligase 4 (CRL4) complex, is a direct protein target for thalidomide teratogenicity and antitumor activity of immunomodulatory drugs (IMiDs).
T. Nguyen +14 more
semanticscholar +1 more source
Crystal structure of the Large Type III Glutamine Synthetase from Bacteroides Fragilis [PDF]
, 2010 Glutamine synthetases are one of the most ancient functioning enzymes in existence and these large oligomeric complexes are found in all extant forms of life where they play a critical role in nitrogen metabolism.
van Rooyen, Jason M
core
Advances in human glutamine-hydrolyzing synthetases and their therapeutic potential
Frontiers in Chemical BiologyBifunctional enzymes, characterized by their dual active sites, enable efficient chemical conversion and substrate channeling using elegant coupling mechanisms to coordinate the two active sites. In humans, several bifunctional enzymes synthesize de novo
Wen Zhu +2 more
doaj +1 more source
BMC Evolutionary Biology, 2009 Background Although the gene encoding for glutamine synthetase (glnA) is essential in several organisms, multiple glnA copies have been identified in bacterial genomes such as those of the phylum Actinobacteria, notably the mycobacterial species ...
Wiid Ian JF +2 more
doaj +1 more source
Reassimilation of Photorespiratory Ammonium in Lotus japonicus Plants Deficient in Plastidic Glutamine Synthetase. [PDF]
PLoS ONE, 2015 It is well established that the plastidic isoform of glutamine synthetase (GS2) is the enzyme in charge of photorespiratory ammonium reassimilation in plants.
Carmen M Pérez-Delgado +3 more
doaj +1 more source