TLR3 and GLUL orchestrate inflammatory and homeostatic imbalance in osteoarthritis [PDF]
Frontiers in ImmunologyIntroductionOsteoarthritis (OA) is a degenerative joint disease marked by chronic inflammation, extracellular matrix degradation, and dysregulated cell death.
Yanguo Qin, Peiqiang Peng
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Expanding the clinical and genetic spectrum of GLUL-related developmental and epileptic encephalopathy [PDF]
Scientific ReportsThe GLUL gene encodes glutamine synthetase (GS), which plays a crucial role in glutamine–glutamate homeostasis. Both loss-of-function and gain-of-function variants of GLUL are known to cause genetic disorders in humans.
Ki Joong Kim +2 more
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A novel EGR1-driven GLUL/mTOR axis regulates macropinocytosis-mediated crosstalk in pancreatic stellate cell-cancer metastasis [PDF]
Journal of Translational MedicineBackground Pancreatic cancer liver metastasis relies on crosstalk between pancreatic stellate cells (PSCs) and cancer cells, yet the role of transcriptional regulation in this interplay, particularly via macropinocytosis, remains unclear.
Ran Xue +5 more
doaj +2 more sources
Frontiers in Oncology, 2022 Nasopharyngeal carcinoma (NPC) is often associated with the infection of Epstein-Barr virus in nasopharynx and is mainly happened in South China and Southeast Asia. Recently, noncoding RNAs have been reported to regulate NPC carcinogenesis.
Junyi Liang
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GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression [PDF]
Advanced ScienceGlioblastoma (GBM) is a malignant brain tumor characterized by profound angiogenic activity and immunosuppressive features. A burgeoning body of research has focused on elucidating the functional effects of stromal cells within the tumor microenvironment
Qing Zhang +4 more
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GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer
Acta Pharmaceutica Sinica BGlutamate-ammonia ligase (GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation.
Zhe-Sheng Chen, Zhi Shi, Xingyuan Shi
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RHOJ derived peptide promotes chemosensitivity by inhibiting glutamine metabolism in gastric cancer [PDF]
Journal of Translational MedicineBackground Chemoresistance is a cause of chemotherapy failure in gastric cancer (GC) treatment. Recent studies have shown that the dysregulation of glutamine metabolism plays a pivotal role in promoting chemoresistance.
Jian Li +8 more
doaj +2 more sources
S100A8+S100A9+ transitional macrophages are associated with pulmonary fibrosis progression by integrating immunometabolism and fibrogenic crosstalk [PDF]
Frontiers in ImmunologyBackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options. Although macrophage heterogeneity has been implicated in pathogenesis, the contribution of transitional macrophage states remains ...
Censhan Lin +18 more
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Targeting the Glutamine Transporter SLC1A5 Enhances Sensitivity of Acute Myeloid Leukemia to MLN4924 [PDF]
BiomedicinesBackground/Objectives: Acute myeloid leukemia (AML) remains a hematologic malignancy with poor prognosis. The neddylation inhibitor MLN4924 has demonstrated potent anti-leukemic activity in preclinical models, yet its clinical translation faces ...
Yin Wang +6 more
doaj +2 more sources
Bioinformatics-based study on the regulatory network of lipid metabolism-related genes and mechanisms in coronary heart disease [PDF]
HereditasCoronary heart disease (CHD), is a complex cardiovascular disease driven by atherosclerosis, resulting from a dynamic interplay between dysregulated lipid metabolism and chronic inflammation.
Zunxiong Xiao +5 more
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