Results 21 to 30 of about 4,820 (182)

Sinomenine regulates the AKT/FOXO3/GLUL pathway to inhibit pulmonary fibroblast-to-myofibroblast transition via α7nAChR against rheumatoid arthritis associated interstitial lung disease

Pharmacological Research
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a severe extra-articular manifestation with limited treatment options. Identifying anti-arthritic agents that concurrently protect against ILD is clinically significant.
Muqiu Liu, Huaizhi Du, Junhui Zheng, Min Liu, Zhihao Jiang, Jieying Huang, Sihe Jiang, Lang Yi, Lingyu Zhang, Yanwu Li, Qun Du, Liang Liu, Haojie Ni, Xiaojun Zhang, Hua Zhou, Yan Dong   +15 more
doaj   +2 more sources

FISH mapping of three ammonia metabolism genes (Glul, Cps1, Glud1) in rat, and the chromosomal localization of GLUL in human and Cps1 in mouse [PDF]

Mammalian Genome, 1997
In recent years, the rat genes encoding glutamate dehydrogenase (GLUD; Das et al. 1993), glutamine synthetase (glutamateammonia ligase, GLUL; van de Zande et al. 1990) and carbamoylphosphate synthetase 1 (CPS; Van den Hoff et al. 1995) have been isolated.
Khalil Helou, Atze T. Das, Wouter H. Lamers, Jan M. N. Hoovers, Claude Szpirer, Josiane Szpirer, Karin Klinga‐Levan, Göran Levan   +7 more
openalex   +6 more sources

GLUL facilitates thrombocytopoiesis by restricting ammonia accumulation during megakaryocyte maturation

Blood Journal
Polyploidization resulted from massive DNA synthesis is crucial for megakaryocyte maturation, while the regulatory mechanisms of cell fitness upon this special cellular process remain poorly understood. Here, we reveal that glutamine synthetase (GLUL) facilitates thrombocytopoiesis by restricting ammonia accumulation during polyploidization.
Jun Chen, Zijiao Li, Yimin Zhang, Baichuan Xu, Fengxi Chen, Mo Chen, Mingqiang Shen, Mengjia Hu, Xi Ran, Song Wang, Ronghua Diao, Jinghong Zhao, Qian Zhang (49333), Ye Fan, Yang Xu, Junping Wang   +15 more
openalex   +2 more sources

GLUL Drives Metabolic Reprogramming and Confers Docetaxel Resistance in Prostate Cancer

Biochemical Pharmacology
Docetaxel is a first-line chemotherapeutic agent for advanced and castration-resistant prostate cancer (CRPC), yet acquired resistance limits its long-term efficacy. Metabolic reprogramming has emerged as a central mechanism of therapeutic resistance; however, the metabolic determinants of docetaxel resistance remain incompletely defined.Here, we ...
Zihang Wu, Xiangwei Wang, Ran Xu, Yuqi Wu, Qiuxia Ding, Wei Huang, Yuanfei Huang, YING ZHANG   +7 more
  +4 more sources

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism [PDF]

Cell Reports, 2019
Summary: Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/survival of
Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Wouter H. Lamers, Daniel J. Murphy, Jessie Yanxiang Guo, Jian Jin, Howard C. Crawford, Lanjing Zhang, Eileen White, Richard Z. Lin, Xiaoyang Su, David A. Tuveson, Wei-Xing Zong   +28 more
doaj   +2 more sources

MicroRNA-140-5p suppresses invasion and proliferation of glioma cells by targeting glutamate-ammonia ligase (GLUL)

Neoplasma, 2020
Glutamine addiction is a major feature of glioma cells and plays an important role in its growth and proliferation. GLUL (glutamate-ammonia ligase), which catalyzes glutamate and ammonia to synthesize glutamine, plays a crucial role in tumor growth and proliferation.
R. ZHANG, Jinghan Zhu, Haili Hu, Quanyang Lin, Wenjia Shao, Tian-Rui Ji   +5 more
openalex   +5 more sources

Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study [PDF]

Diabetes, 2015
Genetic studies have identified a glutamate-ammonia ligase gene (GLUL) polymorphism associated with cardiovascular disease morbidity and mortality among people with type 2 diabetes (T2D). We sought to determine whether GLUL rs10911021 is associated prospectively with adjudicated cardiovascular composite end points among overweight/obese individuals ...
The Look AHEAD Research Group
openalex   +4 more sources

SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL

Gut
Background SIRT6 acts as a tumour suppressor in multiple cancers by regulating glucose and lipid metabolism, but its role in intrahepatic cholangiocarcinoma (ICC) remains unclear. Objective We investigated the role and molecular ...
Mi Zhang, Chanyuan Chen, Haifeng Zhang, Tanqing Long, Tingjie Wang, Nanjin Ding, Ruitao Long, Hua Jian Wu, Zhilu Ma, Zhongyu Cheng, Junyan Tao, Dong Kuang, Lei Li, Chuanrui Xu   +13 more
openalex   +3 more sources

ALDH1L1 reverses CD8+ T cell exhaustion in the oral squamous cell carcinoma microenvironment by reprogramming L-glutamate metabolism [PDF]

Journal of Translational Medicine
Background Oral squamous cell carcinoma (OSCC) induces CD8⁺ T-cell exhaustion within the tumor microenvironment (TME) through metabolic reprogramming, contributing to the limited efficacy of immunotherapy. Targeting tumor metabolism is a pivotal strategy.
Guanzheng Chen, Shuqi Zhao, Lin Zhu, Shifeng Wu, Jia Kang, Minghui Mao, Zhengxue Han, Yi Qu   +7 more
doaj   +2 more sources

Genome‐wide association analysis identifies a GLUL haplotype for familial hepatitis B virus‐related hepatocellular carcinoma [PDF]

Cancer, 2017
BACKGROUNDA family history of liver cancer increases the risk of developing hepatocellular carcinoma (HCC) by 2‐fold to 10‐fold among patients with chronic hepatitis B virus (HBV). Previous genome‐wide association studies have identified many possible susceptible loci associated with sporadic HBV‐related HCC.
You‐Yu Lin, Ming‐Whei Yu, Shi‐Ming Lin, Shou‐Dong Lee, Chih‐Ling Chen, Ding‐Shinn Chen, Pei‐Jer Chen   +6 more
openalex   +4 more sources