Results 21 to 30 of about 7,364 (182)

Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity [PDF]

Cell Reports Medicine
Summary: Natural killer (NK) cells exhibit impaired anti-tumor activity upon entering the tumor microenvironment (TME); however, the precise mechanism(s) remains elusive.
Rou Zhao, Baoyu He, Lunhua Huang, Yanli Wu, Ting Liu, Jilan Liu, Mingsheng Zhao, Tao Zhong, Yanhua Zhang, Xiao Zhang, Huabao Xiong, Bin Zhang, Qingli Bie   +12 more
doaj   +2 more sources

SIRT6-GLUL axis: rewiring nitrogen metabolism in intrahepatic cholangiocarcinoma. [PDF]

Gut
Zhou H, Li H, Wu N, Calvisi DF.
europepmc   +4 more sources

Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration [PDF]

Bone Research
Intervertebral disc degeneration (IDD) is a progressive and dynamic process in which the senescence-associated secretory phenotype (SASP) of nucleus pulposus cells (NPC) plays a significant role. While impaired chaperone-mediated autophagy (CMA) has been
Zhangrong Cheng, Haiyang Gao, Pengzhi Shi, Anran Zhang, Xianglong Chen, Yuhang Chen, Weikang Gan, Kangcheng Zhao, Shuai Li, Cao Yang, Yukun Zhang   +10 more
doaj   +2 more sources

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease [PDF]

Advanced Science
Serine Hydroxymethyltransferase 1 (SHMT1) plays a pivotal role in one‐carbon metabolism, facilitating the production of SAM. In this study, dysregulation of one‐carbon metabolism is reported in both Parkinson's disease (PD) patients and animal models ...
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
doaj   +2 more sources

Underlying mechanisms of phosphodiesterase 10A and glutamate-ammonia ligase genes that regulate inosine monophosphate deposition and thereby affect muscle tenderness in Jingyuan chickens [PDF]

Animal Bioscience, 2022
Objective Inosine monophosphate (IMP) is a key factor that imparts of meat flavor. Differences in the IMP content in the muscles were evaluated to improve chicken meat quality.
Weizhen Wang, Juan Zhang, Honghong Hu, Baojun Yu, Jintong He, Tingting Yao, Yaling Gu, Zhengyun Cai, Guosheng Xin   +8 more
doaj   +1 more source

Inhibitory Activity of Conferone on FAK Activity and Glutamine Metabolism in Human Colorectal Cancer. [PDF]

J Cell Mol Med
ABSTRACT Colorectal cancer (CRC) is a major global cause of death, with metastases and chemotherapy resistance contributing to poor outcomes. To identify natural compounds with anticancer potential against CRC and elucidate their action mechanisms, the cytotoxicity of 37 natural compounds was evaluated against the HCT116, leading to the identification ...
Ong HTM, Ates E, Jung J, Sung JS, Pyun JC, Kang MJ.   +5 more
europepmc   +2 more sources

FISH mapping of three ammonia metabolism genes (Glul, Cps1, Glud1) in rat, and the chromosomal localization of GLUL in human and Cps1 in mouse [PDF]

Mammalian Genome, 1997
In recent years, the rat genes encoding glutamate dehydrogenase (GLUD; Das et al. 1993), glutamine synthetase (glutamateammonia ligase, GLUL; van de Zande et al. 1990) and carbamoylphosphate synthetase 1 (CPS; Van den Hoff et al. 1995) have been isolated.
Helou, Khalil, Das, A T, Lamers, W H, Hoovers, J M, Szpirer, Claude, Szpirer, Josiane, Klinga-Levan, K, Levan, G   +7 more
openaire   +4 more sources

Homozygous GLUL deletion is embryonically viable and leads to glutamine synthetase deficiency [PDF]

Clinical Genetics, 2020
AbstractGlutamine synthetase (GS) is the enzyme responsible for the biosynthesis of glutamine, providing the only source of endogenous glutamine necessary for several critical metabolic and developmental pathways. GS deficiency, caused by pathogenic variants in the glutamate‐ammonia ligase (GLUL) gene, is a rare autosomal recessive inborn error of ...
Roifman, Maian, Niles, Kirsten M, MacNeil, Lauren, Blaser, Susan, Noor, Abdul, Godoy, Ruth, van Mieghem, Tim, Ryan, Greg, Seaward, Gareth, Sondheimer, Neal, Mercimek-Andrews, Saadet, Schulze, Andreas, Hewson, Stacy, Ovadia, Adi, Chitayat, David, Morgen, Eric K, Hojilla, Carlo, Kolomietz, Elena, Watkins, Nicholas, Häberle, Johannes, Shannon, Patrick   +20 more
openaire   +4 more sources

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Every Hilbert space frame has a Naimark complement [PDF]

, 2002
Naimark complements for Hilbert space Parseval frames are one of the most fundamental and useful results in the field of frame theory. We will show that actually all Hilbert space frames have Naimark complements which possess all the usual properties for
Casazza, Peter G., Fickus, Matt, Mixon, Dustin, Peterson, Jess, Smalyanau, Ihar   +4 more
core   +13 more sources