Targeting Glutamate Excitotoxicity With Memantine Modulates Glial Response and Protects Motoneurons After Spinal Root Lesion. [PDF]
J NeurochemMotoneuron axotomy induced marked neuroinflammation, synaptic withdrawal, and structural remodeling in the ventral root crush (VRC) model, characterized by intense microglial and astroglial activation and reduced synaptic coverage. Memantine treatment produced consistent, dose‐dependent neuroprotection, with maximal effects at 45 mg/kg.
Leão AVM +3 more
europepmc +2 more sources
T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions. [PDF]
PLoS ONE, 2016 Immune responses often take place where nutrients and O2 availability are limited. This has an impact on T cell metabolism and influences activation and effector functions.
Zeynep Sener +4 more
doaj +1 more source
iScience, 2023 Summary: Mutations of the GABA-A receptor subunit β1 (GABRB1) gene are found in autism patients. However, it remains unclear how mutations in Gabrb1 may lead to autism. We generated Gabrb1−/− mouse model, which showed autistic-like behaviors.
Jing Wang +13 more
doaj +1 more source
Cell Reports, 2019 Summary: Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/survival of
Alex J. Bott +28 more
doaj +1 more source
Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth [PDF]
, 2018 In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase (GS),
Andreoli, Roberta +8 more
core +2 more sources
Two Siblings With Valproate-Related Hyperammonemia and Novel Mutations in Glutamine Synthetase (GLUL) Treated With Carglumic Acid [PDF]
Child Neurology Open, 2020 This case report describes 2 siblings with myoclonic epilepsy who had novel mutations in the glutamine synthetase ( GLUL) gene: c.316C>T, p.(Arg106*) and c.42G>C, p.(Lys14Asn). Valproic acid improved seizure control, but was associated with hyperammonemic encephalopathy.
Jennifer Bennett +4 more
openaire +2 more sources
A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer. [PDF]
PLoS ONE, 2014 Pathways involved in the synthesis of the neurotransmitter gamma-aminobutyric acid (GABA) have been implicated in the pathogenesis of high grade neuroendocrine (NE) neoplasms as well as neoplasms from a non-NE lineage.
Joseph E Ippolito, David Piwnica-Worms
doaj +1 more source
Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster? [PDF]
, 2019 Distinct from normal differentiated tissues, cancer cells reprogram nutrient uptake and utilization to accommodate their elevated demands for biosynthesis and energy production.
Jiang, Jie +2 more
core +1 more source
Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis
Adipocyte, 2021 Objectives Adipocytes and adipocyte lipid metabolism are closely related with obesity and type 2 diabetes, but the molecular mechanism still needs further investigation.
Zhiyong Dong +5 more
doaj +1 more source
Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival [PDF]
Journal of Cancer Research and Clinical Oncology, 2021 Abstract Purpose Glutamine plays an important role in cell viability and growth of various tumors. For the fetal subtype of hepatoblastoma, growth inhibition through glutamine depletion was shown. We studied glutamine depletion in embryonal cell lines of hepatoblastoma carrying different mutations.
Andreas Schmidt +9 more
openaire +3 more sources