Results 31 to 40 of about 4,820 (182)

PO-249 GLUL knockdown induces drug resistance in non-small cell lung cancer cells

ESMO Open, 2018
ABSTRACT Introduction Chemotherapy has advanced well in the treatment of Non-Small Cell Lung Cancers (NSCLCs), but its effectiveness is limited by drug resistance. Unfortunately, cancer drug resistance becoming inevitable involving alterations in epigenetic regulation, molecular signalling, and metabolic rewiring.
Magesh Muthu, Anders Nordström
openalex   +2 more sources

Using TMAs (Tissue MicroArrays) to Evaluate GLS, GLUL, and CAV 1 Immunostaining in Breast Cancer [PDF]

, 2016
poster abstractApproximately 1 out of 8 women in the United States will develop invasive breast cancer over the course of their lifetime. Breast cancer has a greater potential of being cured if diagnosed in the earlier phases.
Courtney Finnearty, Ayesha N. Shajahan‐Haq, Hari Nakshatri, George Earl Sandusky   +3 more
core   +3 more sources

Specific inhibition of glutamine synthase involved in the metabolic pathway of amino acids is associated with anti-arthritic effects of sinomenine hydrochloride [PDF]

Frontiers in Cell and Developmental Biology
Sinomenine (SIN) is the key bioactive alkaloid isolated from Sinomenium acutum which has been prescribed commonly in Chinese medicine for managing rheumatic disorders.
Gejing Li, Gejing Li, Zhaoli Su, Yuanyuan Tang, Hong Huang, Junlan Zhang, Ye Lin, Qin Zhang, Xiong Cai, Xiong Cai   +9 more
doaj   +2 more sources

COVID-19 multi-omics reveal organ-specific responses and biomarkers [PDF]

Journal of Translational Medicine
Objective Post-COVID-19 syndrome is characterised by persistent immune dysfunction and multi-organ sequelae. This study aimed to characterise the systemic blood molecular landscape induced by SARS-CoV-2 infection and identify prognostic markers linked to
Xian Ding, Qiuhan Lu, Ting Hu, Yi Zhang, Rui Zhao, Haolong Liu, Sicheng Huang, Yuwen Wu, Zhaohui Tong, Guozhi Jiang, Zhuoling An   +10 more
doaj   +2 more sources

Identification of common mechanisms and biomarkers of atrial fibrillation and heart failure based on machine learning

ESC Heart Failure
Aims Atrial fibrillation (AF) is the most common arrhythmia. Heart failure (HF) is a disease caused by heart dysfunction. The prevalence of AF and HF were progressively increasing over time.
Zhijun Zhang, Jianying Ding, Xiaolong Mi, Yuanyuan Lin, Xinjian Li, Jun Lian, Jinwen Liu, Lijuan Qu, Bingye Zhao, Xuewen Li   +9 more
doaj   +2 more sources

In Silico Preliminary Association of Ammonia Metabolism Genes GLS, CPS1, and GLUL with Risk of Alzheimer’s Disease, Major Depressive Disorder, and Type 2 Diabetes

Journal of Molecular Neuroscience, 2018
Ammonia is a toxic by-product of protein catabolism and is involved in changes in glutamate metabolism. Therefore, ammonia metabolism genes may link a range of diseases involving glutamate signaling such as Alzheimer's disease (AD), major depressive disorder (MDD), and type 2 diabetes (T2D).
Griffin, Jeddidiah W.D., Liu, Ying, Bradshaw, Patrick C., Wang, Kesheng   +3 more
openaire   +4 more sources

Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity [PDF]

Cell Reports Medicine
Summary: Natural killer (NK) cells exhibit impaired anti-tumor activity upon entering the tumor microenvironment (TME); however, the precise mechanism(s) remains elusive.
Rou Zhao, Baoyu He, Lunhua Huang, Yanli Wu, Ting Liu, Jilan Liu, Mingsheng Zhao, Tao Zhong, Yanhua Zhang, Xiao Zhang, Huabao Xiong, Bin Zhang, Qingli Bie   +12 more
doaj   +2 more sources

Microglial GLUL loss worsens TBI outcomes by amplifying the arginine-citrulline pathway

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Li Jianwei, Zhao Yuanlin, Yang Yang, Dai Qiulong, Tian Rong, Wang Jipeng, Ye Jing, Zhang Lijun, Li Lihong   +8 more
openalex   +2 more sources

Underlying mechanisms of phosphodiesterase 10A and glutamate-ammonia ligase genes that regulate inosine monophosphate deposition and thereby affect muscle tenderness in Jingyuan chickens [PDF]

Animal Bioscience, 2022
Objective Inosine monophosphate (IMP) is a key factor that imparts of meat flavor. Differences in the IMP content in the muscles were evaluated to improve chicken meat quality.
Weizhen Wang, Juan Zhang, Honghong Hu, Baojun Yu, Jintong He, Tingting Yao, Yaling Gu, Zhengyun Cai, Guosheng Xin   +8 more
doaj   +1 more source

A “DUBTAC” targeting GLUL deubiquitination promotes BMSC osteogenic differentiation and implant osseointegration in type 2 diabetes

Journal of Advanced Research
Lingxiao Wang, Zhanqiu Diao, Wanqing Wang, Y. Huang, Yang Liu, Zhenhua Gao, Pan Ma, Zhaochen Shan, Jie Li, Zhipeng Fan   +9 more
  +4 more sources