Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer
Frontiers in Oncology, 2023 Glutamine, the most abundant non-essential amino acid in human blood, is crucial for cancer cell growth and cancer progression. Glutamine mainly functions as a carbon and nitrogen source for biosynthesis, energy metabolism, and redox homeostasis ...
Rui Ni +6 more
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Glutamine metabolism remodels tumor-associated macrophage: mechanistic explorations and new strategies in translational medicine [PDF]
Frontiers in ImmunologyGlutamine metabolism provides energy and raw materials for tumor survival and proliferation. In addition to affecting cancer cells, many studies have investigated the role of glutamine metabolism on the tumor microenvironment in depth.
Juya Cui, Juya Cui, Xia Yan, Jianbo Song
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RHOJ derived peptide promotes chemosensitivity by inhibiting glutamine metabolism in gastric cancer [PDF]
Journal of Translational MedicineBackground Chemoresistance is a cause of chemotherapy failure in gastric cancer (GC) treatment. Recent studies have shown that the dysregulation of glutamine metabolism plays a pivotal role in promoting chemoresistance.
Jian Li +8 more
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ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression [PDF]
Cell DiscoveryS-palmitoylation, a reversible post-translational modification regulates protein stability and cellular functions, yet its role in glutamine metabolism remains unclear.
Xingyu Chen +14 more
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Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases [PDF]
MedCommGlutaminolysis, the metabolic process of converting glutamine into key intermediates, plays an essential role in cellular energy production, signaling, biosynthesis, and redox balance. Deregulation of glutamine metabolism significantly influences various
Mudasir A. Kumar +10 more
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Targeting the glutamine-arginine-proline metabolism axis in cancer
Journal of Enzyme Inhibition and Medicinal ChemistryMetabolic abnormalities are an important feature of tumours. The glutamine-arginine-proline axis is an important node of cancer metabolism and plays a major role in amino acid metabolism.
Di Wang +6 more
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Targeting glutamine metabolism as a potential target for cancer treatment [PDF]
Journal of Experimental & Clinical Cancer ResearchMetabolic reprogramming is a hallmark of cancer cells, and the advent of “glutamine addiction” in numerous tumors signifies a pivotal advancement for precision-targeted therapy.
Wenxuan Zou +3 more
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Integrated analysis of glutamine metabolism and immune microenvironment identifies GOT2 as a prognostic gene in head and neck squamous cell carcinoma [PDF]
Discover OncologyGlutamine metabolism plays a key role in cancer initiation and progression. This study aims to explore the independent and interactive roles of glutamine metabolism-related genes and immune characteristic in head and neck squamous cell carcinoma (HNSCC).
Xikong Pan +3 more
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Overview of glutamine metabolism in stromal components of the tumor microenvironment and potential anti-tumor therapies [PDF]
Genes and DiseasesAs a critical metabolite in the tumor microenvironment, glutamine plays a crucial role in tumor progression, and its dual effects on promoting and inhibiting tumors have garnered increasing attention in recent years.
Zizhuo Li +9 more
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Glutamine metabolic reprogramming in hepatocellular carcinoma
Frontiers in Molecular Biosciences, 2023 Hepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including glutamine metabolic reprogramming.
Yanyan Ye +6 more
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