Targeting the glutamine-arginine-proline metabolism axis in cancer [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryMetabolic abnormalities are an important feature of tumours. The glutamine-arginine-proline axis is an important node of cancer metabolism and plays a major role in amino acid metabolism.
Di Wang +6 more
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Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer
Frontiers in Oncology, 2023 Glutamine, the most abundant non-essential amino acid in human blood, is crucial for cancer cell growth and cancer progression. Glutamine mainly functions as a carbon and nitrogen source for biosynthesis, energy metabolism, and redox homeostasis ...
Rui Ni +6 more
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Illuminating spatial dynamics of glutamine metabolism with a sensitive genetically encoded biosensor [PDF]
RSC Chemical BiologyGlutamine is the most abundant amino acid in serum, used as a key nutrient by cells for protein synthesis, energy production, carbon and nitrogen metabolism, and cellular redox balance.
Jack M. Scully +10 more
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Glutamine metabolism in health and disease [PDF]
Signal Transduction and Targeted TherapyGlutamine is the most abundant free amino acid in the body. It plays a central role in cellular metabolism, connecting synthetic and catabolic pathways, and maintaining life activities under physiological and pathological conditions.
Junsheng Zhao +4 more
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Glutamine Metabolism in Health and Diseases [PDF]
MedCommGlutamine, the most abundant nonessential amino acid in the blood and tissues, plays essential roles in cellular proliferation, immune regulation, acid–base homeostasis, and metabolic balance.
Yi Ding +3 more
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Plumbagin Is a PKM2 Activator That Modulates Glutamine Metabolism and Dependency in Leukemia [PDF]
MetabolitesBackground: AML cells can be defined by impairments in glycolytic metabolism, resulting in increased glucose uptake coupled with reduced glycolytic flux.
Nikolina Vrdoljak +2 more
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Glutamine metabolism remodels tumor-associated macrophage: mechanistic explorations and new strategies in translational medicine [PDF]
Frontiers in ImmunologyGlutamine metabolism provides energy and raw materials for tumor survival and proliferation. In addition to affecting cancer cells, many studies have investigated the role of glutamine metabolism on the tumor microenvironment in depth.
Juya Cui, Juya Cui, Xia Yan, Jianbo Song
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Glutamine metabolism and its roles in tumor radiotherapy by regulating DNA damage repair [PDF]
Frontiers in Cell and Developmental BiologyBackgroundAs a conditionally essential amino acid that is required by tumor cells, glutamine serves as a key metabolic hub in tumor cells, functioning both as a carbon source for the tricarboxylic acid cycle and lipid synthesis and as a nitrogen source ...
Yuwei Huang +7 more
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RHOJ derived peptide promotes chemosensitivity by inhibiting glutamine metabolism in gastric cancer [PDF]
Journal of Translational MedicineBackground Chemoresistance is a cause of chemotherapy failure in gastric cancer (GC) treatment. Recent studies have shown that the dysregulation of glutamine metabolism plays a pivotal role in promoting chemoresistance.
Jian Li +8 more
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ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression [PDF]
Cell DiscoveryS-palmitoylation, a reversible post-translational modification regulates protein stability and cellular functions, yet its role in glutamine metabolism remains unclear.
Xingyu Chen +14 more
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