Results 11 to 20 of about 318,213 (301)
Cell Communication and Signaling, 2022 Metabolic reprogramming and immune escape play a major role in tumorigenesis. Increasing number of studies have shown that reprogramming of glutamine metabolism is a putative determinant of the anti-tumor immune response in the tumor microenvironment ...
Guofeng Ma +10 more
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Cell Death and Disease, 2023 Anaplastic thyroid cancer (ATC) is one of the most aggressive tumors with an extremely poor prognosis. Based on the several biological features related to glutamine metabolism in ATC, we hypothesized glutaminolysis inhibition induces cell death in ATC ...
Yeseong Hwang +8 more
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Targeting glutamine metabolism as a therapeutic strategy for cancer
Experimental and Molecular Medicine, 2023 Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as well as a source of nitrogen for amino acid and nucleotide ...
Jonghwa Jin +3 more
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Glutamine Metabolism in Cancer
, 2021 AbstractMetabolism is a fundamental process for all cellular functions. For decades, there has been growing evidence of a relationship between metabolism and malignant cell proliferation. Unlike normal differentiated cells, cancer cells have reprogrammed metabolism in order to fulfill their energy requirements. These cells display crucial modifications
Ting, Li +2 more
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GLUTAMINE METABOLISM OF THE BEET [PDF]
Plant Physiology, 1936 Although glutamine has long been known as a plant constituent (10), the relationship of this amide to the nitrogen metabolism of the plant has seldom been subjected to direct test. The close analogy in chemical structure with asparagine and the similarity of the conditions under which the respective amides are found have led to the view, early ...
H B, Vickery, G W, Pucher, H E, Clark
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Take Advantage of Glutamine Anaplerosis, the Kernel of the Metabolic Rewiring in Malignant Gliomas
Biomolecules, 2020 Glutamine is a non-essential amino acid that plays a key role in the metabolism of proliferating cells including neoplastic cells. In the central nervous system (CNS), glutamine metabolism is particularly relevant, because the glutamine-glutamate cycle ...
Filipa Martins +3 more
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Scientific Reports, 2022 Glutamine provides carbon and nitrogen for macromolecular synthesis and participates in adenosine triphosphate (ATP) generation, anabolic metabolism, redox homeostasis, cell signaling, and cancer stem cell (CSC) metabolism.
Yoojeong Seo +3 more
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Glutamine Metabolism Supports the Functional Activity of Immune Cells against Aspergillus fumigatus
Microbiology Spectrum, 2023 The reprogramming of cellular metabolism of immune cells is an essential process in the regulation of antifungal immune responses. In particular, glucose metabolism has been shown to be required for protective immunity against infection with Aspergillus ...
Daniela Antunes +16 more
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Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster? [PDF]
, 2019 Distinct from normal differentiated tissues, cancer cells reprogram nutrient uptake and utilization to accommodate their elevated demands for biosynthesis and energy production.
Jiang, Jie +2 more
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Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells. [PDF]
, 2015 A network model for the determination of tumor metabolic fluxes from (13)C NMR kinetic isotopomer data has been developed and validated with perfused human DB-1 melanoma cells carrying the BRAF V600E mutation, which promotes oxidative metabolism.
Blair, Ian A +9 more
core +2 more sources