Results 11 to 20 of about 1,091,861 (290)

Ovarian Cancer and Glutamine Metabolism

International Journal of Molecular Sciences, 2023
Cancer cells are known to have a distinct metabolic profile and to exhibit significant changes in a variety of metabolic mechanisms compared to normal cells, particularly glycolysis and glutaminolysis, in order to cover their increased energy requirements.
Marianna Theodora, Athina Samara, Antonios Koutras   +2 more
exaly   +6 more sources

Glutamine Metabolism in Brain Tumors [PDF]

Cancers, 2019
Altered metabolism is a hallmark of cancer cells. Tumor cells rewire their metabolism to support their uncontrolled proliferation by taking up nutrients from the microenvironment. The amino acid glutamine is a key nutrient that fuels biosynthetic processes including ATP generation, redox homeostasis, nucleotide, protein, and lipid synthesis.
Sriram Venneti, Siva Kumar Natarajan
exaly   +4 more sources

Targeting the glutamine-arginine-proline metabolism axis in cancer [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Metabolic abnormalities are an important feature of tumours. The glutamine-arginine-proline axis is an important node of cancer metabolism and plays a major role in amino acid metabolism.
Di Wang, Jiang-jie Duan, Yu-feng Guo, Jun-jie Chen, Tian-qing Chen, Jun Wang, Shi-cang Yu   +6 more
doaj   +4 more sources

Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer

Frontiers in Oncology, 2023
Glutamine, the most abundant non-essential amino acid in human blood, is crucial for cancer cell growth and cancer progression. Glutamine mainly functions as a carbon and nitrogen source for biosynthesis, energy metabolism, and redox homeostasis ...
Rui Ni, Ziwei Li, Li Li, Dan Peng, Yue Ming, Lin Li, Yao Liu   +6 more
doaj   +3 more sources

Glutamine Metabolism in Cancer

, 2021
AbstractMetabolism is a fundamental process for all cellular functions. For decades, there has been growing evidence of a relationship between metabolism and malignant cell proliferation. Unlike normal differentiated cells, cancer cells have reprogrammed metabolism in order to fulfill their energy requirements. These cells display crucial modifications
Ting, Li, Christopher, Copeland, Anne, Le   +2 more
openaire   +3 more sources

Illuminating spatial dynamics of glutamine metabolism with a sensitive genetically encoded biosensor [PDF]

RSC Chemical Biology
Glutamine is the most abundant amino acid in serum, used as a key nutrient by cells for protein synthesis, energy production, carbon and nitrogen metabolism, and cellular redox balance.
Jack M. Scully, Michael J. Sun, Siddharth Das, Nataly J. Arias, Edmund D. Kapelczak, Tiffany D. Robinson, Katie G. Vineall, Teagan S. Dean, Tara TeSlaa, Ajit S. Divakaruni, Danielle L. Schmitt   +10 more
doaj   +2 more sources

Targeting glutamine metabolism as a therapeutic strategy for cancer

Experimental and Molecular Medicine, 2023
Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as well as a source of nitrogen for amino acid and nucleotide ...
Jonghwa Jin, Jun-Kyu Byun, Yeon-Kyung Choi, Keun-Gyu Park   +3 more
doaj   +2 more sources

Plumbagin Is a PKM2 Activator That Modulates Glutamine Metabolism and Dependency in Leukemia [PDF]

Metabolites
Background: AML cells can be defined by impairments in glycolytic metabolism, resulting in increased glucose uptake coupled with reduced glycolytic flux.
Nikolina Vrdoljak, Mark D. Minden, Paul A. Spagnuolo   +2 more
doaj   +2 more sources

Glutamine reliance in cell metabolism [PDF]

Experimental & Molecular Medicine, 2020
AbstractAs knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial glutamine metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the emergence of drug ...
Hee Chan Yoo, Ya Chun Yu, Yulseung Sung, Jung Min Han   +3 more
openaire   +4 more sources

Glutamine metabolism remodels tumor-associated macrophage: mechanistic explorations and new strategies in translational medicine [PDF]

Frontiers in Immunology
Glutamine metabolism provides energy and raw materials for tumor survival and proliferation. In addition to affecting cancer cells, many studies have investigated the role of glutamine metabolism on the tumor microenvironment in depth.
Juya Cui, Juya Cui, Xia Yan, Jianbo Song
doaj   +2 more sources