Results 11 to 20 of about 1,150,143 (287)

Glutamine reliance in cell metabolism [PDF]

Experimental & Molecular Medicine, 2020
Abstract As knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial glutamine metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the ...
Hee Chan Yoo, Ya Chun Yu, Yulseung Sung, Jung Min Han   +3 more
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Targeting glutamine metabolism as a therapeutic strategy for cancer

Experimental and Molecular Medicine, 2023
Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as well as a source of nitrogen for amino acid and nucleotide ...
Jonghwa Jin, Jun-Kyu Byun, Yeon-Kyung Choi, Keun-Gyu Park   +3 more
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Ovarian Cancer and Glutamine Metabolism

International Journal of Molecular Sciences, 2023
Cancer cells are known to have a distinct metabolic profile and to exhibit significant changes in a variety of metabolic mechanisms compared to normal cells, particularly glycolysis and glutaminolysis, in order to cover their increased energy requirements.
Zacharias Fasoulakis, Antonios Koutras, Thomas Ntounis, Ioannis Prokopakis, Paraskevas Perros, Athanasios Chionis, Ioakeim Sapantzoglou, Alexandros Katrachouras, Kyriakos Konis, Athina A. Samara, Asimina Valsamaki, Vasileios-Chrysovalantis Palios, Panagiotis Symeonidis, Konstantinos Nikolettos, Athanasios Pagkalos, Sotirios Sotiriou, Marianna Theodora, Panos Antsaklis, Georgios Daskalakis, Emmanuel N. Kontomanolis   +19 more
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Glutamine Metabolism Is Required for Alveolar Regeneration during Lung Injury

Biomolecules, 2022
(1) Background: Abnormal repair after alveolar epithelial injury drives the progression of idiopathic pulmonary fibrosis (IPF). The maintenance of epithelial integrity is based on the self-renewal and differentiation of alveolar type 2 (AT2) cells, which
Sisi Wang, Xue Li, Qingwen Ma, Qi Wang, Junping Wu, Hongzhi Yu, Kuan Li, Yu Li, Jianhai Wang, Qiuyang Zhang, Youwei Wang, Qi Wu, Huaiyong Chen   +12 more
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Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets

Cell Communication and Signaling
Glutamine is the most abundant amino acid in human serum, and it can provide carbon and nitrogen for biosynthesis, which is crucial for proliferating cells. Moreover, it is widely known that glutamine metabolism is reprogrammed in cancer cells.
Ding Nan, Weiping Yao, Luanluan Huang, Ruiqi Liu, Xiaoyan Chen, Wenjie Xia, Hailong Sheng, Haibo Zhang, Xiaodong Liang, Yanwei Lu   +9 more
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Response of glutamine metabolism to exogenous glutamine in humans

American Journal of Physiology-Endocrinology and Metabolism, 1995
To determine whether exogenous glutamine affects whole body glutamine metabolism, preliminary experiments were performed to verify that L-[1-13C]-, L-[U-14C]-, and L-[3,4-3H]glutamine given simultaneously by vein provided similar estimates of glutamine appearance rates [Ra; 355 +/- 24, 373 +/- 19, and 393 +/- 24 (SE) mumol.kg-1.h-1, respectively, P ...
R G, Hankard, D, Darmaun, B K, Sager, D, D'Amore, W R, Parsons, M, Haymond   +5 more
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Glutamine metabolic reprogramming in hepatocellular carcinoma

Frontiers in Molecular Biosciences, 2023
Hepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including glutamine metabolic reprogramming.
Yanyan Ye, Bodong Yu, Bodong Yu, Hua Wang, Hua Wang, Fengming Yi, Fengming Yi   +6 more
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Targeting glutamine metabolism as a potential target for cancer treatment [PDF]

Journal of Experimental & Clinical Cancer Research
Metabolic reprogramming is a hallmark of cancer cells, and the advent of “glutamine addiction” in numerous tumors signifies a pivotal advancement for precision-targeted therapy.
Wenxuan Zou, Zitao Han, Zihan Wang, Qian Liu   +3 more
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Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment

Cell Communication and Signaling, 2022
Metabolic reprogramming and immune escape play a major role in tumorigenesis. Increasing number of studies have shown that reprogramming of glutamine metabolism is a putative determinant of the anti-tumor immune response in the tumor microenvironment ...
Guofeng Ma, Zhilei Zhang, Peng Li, Zhao Zhang, Manqin Zeng, Zhijuan Liang, Dan Li, Liping Wang, Yuanbin Chen, Ye Liang, Haitao Niu   +10 more
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Co-inhibition of glutaminolysis and one-carbon metabolism promotes ROS accumulation leading to enhancement of chemotherapeutic efficacy in anaplastic thyroid cancer

Cell Death and Disease, 2023
Anaplastic thyroid cancer (ATC) is one of the most aggressive tumors with an extremely poor prognosis. Based on the several biological features related to glutamine metabolism in ATC, we hypothesized glutaminolysis inhibition induces cell death in ATC ...
Yeseong Hwang, Hyeok Jun Yun, Jae Woong Jeong, Minki Kim, Seyeon Joo, Hae-Kyung Lee, Hang-Seok Chang, Seok-Mo Kim, Sungsoon Fang   +8 more
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