Results 41 to 50 of about 318,213 (301)
BACE1 activity impairs neuronal glucose oxidation:rescue by beta-hydroxybutyrate and lipoic acid [PDF]
, 2015 Glucose hypometabolism and impaired mitochondrial function in neurons have been suggested to play early and perhaps causative roles in Alzheimer's disease (AD) pathogenesis. Activity of the aspartic acid protease, beta-site amyloid precursor protein (APP)
Arsenian +108 more
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Visualization of glutamine transporter activities in living cells using genetically encoded glutamine sensors. [PDF]
PLoS ONE, 2012 Glutamine plays a central role in the metabolism of critical biological molecules such as amino acids, proteins, neurotransmitters, and glutathione. Since glutamine metabolism is regulated through multiple enzymes and transporters, the cellular glutamine
Katrin Gruenwald +5 more
doaj +1 more source
Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment. [PDF]
, 2020 Altered metabolism in pulmonary artery smooth muscle cells (PASMCs) and endothelial cells (PAECs) contributes to the pathology of pulmonary hypertension (PH), but changes in substrate uptake and how substrates are utilized have not been fully ...
D' Alessandro, Angelo +12 more
core +1 more source
Oncoscience, 2014 In a majority of cancer cells, inactivation of the retinoblastoma protein (pRB) through hyperphosphorylation, deletion, or mutation leads to dissociation from E2F effector proteins and aberrant activation of downstream target genes. Suppression of pRB function ultimately results in the loss of regulatory control over multiple biochemical pathways ...
openaire +2 more sources
miRNAs link metabolic reprogramming to oncogenesis [PDF]
, 2013 The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M +2 more
core +1 more source
Glutamine metabolism in lymphocytes of the rat [PDF]
Biochemical Journal, 1983 The metabolism of glutamine in resting and concanavalin-A-stimulated lymphocytes was investigated. In incubated lymphocytes isolated from rat mesenteric lymph nodes, the rates of oxygen and glutamine utilization and that of aspartate production were approximately linear with respect to time for 60 min, and the concentrations of adenine nucleotides plus
M S, Ardawi, E A, Newsholme
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Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]
, 2016 Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel +4 more
core +1 more source
Ecotoxicology and Environmental Safety, 2023 Methyl tertiary-butyl ether (MTBE) is a new unleaded gasoline additive, which is considered to be associated with abnormal lipid metabolism in many studies, but the metabolic characteristics and mechanism are still unclear. To observe the characteristics
Mingxiao Guo +6 more
doaj +1 more source
Intraspecfic variation in cold-temperature metabolic phenotypes of Arabidopsis lyrata ssp petraea [PDF]
, 2009 Atmospheric temperature is a key factor in determining the distribution of a plant species. Alongside this, plant populations growing at the margin of their range may exhibit traits that indicate genetic differentiation and adaptation to their local ...
A Suzuki +40 more
core +1 more source
Ovarian Cancer and Glutamine Metabolism
International Journal of Molecular Sciences, 2023 Cancer cells are known to have a distinct metabolic profile and to exhibit significant changes in a variety of metabolic mechanisms compared to normal cells, particularly glycolysis and glutaminolysis, in order to cover their increased energy requirements.
Zacharias Fasoulakis +19 more
openaire +3 more sources