Results 41 to 50 of about 1,091,861 (290)

Glutamate dehydrogenase 1-dependent α-ketoglutarate promotes hepatitis B virus transcription by modulating histone methylations on the covalently closed circular DNA minichromosome [PDF]

Clinical and Molecular Hepatology
Background/Aims Hepatitis B virus (HBV) hijacks host cell metabolism, especially host glutamine metabolism, to support its replication. Glutamate dehydrogenase 1 (GDH1), a mitochondrial enzyme crucial for glutamine metabolism, can interact with histone ...
Sheng-Tao Cheng, Wei-Xian Chen, Hai-Jun Deng, Xin He, Hui Zhang, Ming Tan, Hai-Bo Yu, Zhen-Zhen Zhang, Ji-Hua Ren, Min-Li Yang, Da-Peng Zhang, Zhi-Hong Li, Juan Chen   +12 more
doaj   +1 more source

Targeting Glutamine Metabolism in Prostate Cancer

Frontiers in Bioscience-Elite, 2023
Glutamine is a conditionally essential amino acid important for cancer cell proliferation through intermediary metabolism leading to de novo synthesis of purine and pyrimidine nucleotides, hexosamine biosytnehsis, fatty acid synthesis through reductive ...
Neil Bhowmick, Edwin Posadas, Leigh Ellis, Stephen J Freedland, Dolores Di Vizio, Michael R Freeman, Dan Theodorescu, Robert Figlin, Jun Gong   +8 more
doaj   +1 more source

Inhibition of lncRNA NEAT1 induces dysfunction of fibroblast-like synoviocytes in rheumatoid arthritis via miRNA-338-3p-mediated regulation of glutamine metabolism

Journal of Orthopaedic Surgery and Research, 2022
Background Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease; cellular glutamine metabolism in fibroblast-like synoviocytes (FLSs) of RA was known to be essential for RA pathogenesis and progression.
Mei Zhang, Ning Lu, Hong-Jun Li, Xiao-Yun Guo, Lu Lu, Ying Guo   +5 more
doaj   +1 more source

GOLM1 Stimulation of Glutamine Metabolism Promotes Osteoporosis via Inhibiting Osteogenic Differentiation of BMSCs

Cellular Physiology and Biochemistry, 2018
Background/Aims: Bone marrow mesenchymal stem cells (BMSCs) play an essential role in osteoporosis. However, the molecular mechanisms and the involvement of glutamine metabolism in osteogenic BMSCs differentiation and osteoporosis remain largely unclear.
Guangsi Shen, Hong Zhang, Peng Jia, Guangfei Li, Xiao Wang, Xiaozhong Zhou, Youjia Xu   +6 more
doaj   +1 more source

Increased Ammonium Toxicity in Response to Exogenous Glutamine in Metastatic Breast Cancer Cells

Metabolites, 2022
Several cancers, including breast cancers, show dependence on glutamine metabolism. The purpose of the present study was to determine the mechanistic basis and impact of differential glutamine metabolism in nonmetastatic and metastatic murine mammary ...
Violet A. Kiesel, Madeline P. Sheeley, Shawn S. Donkin, Michael K. Wendt, Stephen D. Hursting, Dorothy Teegarden   +5 more
doaj   +1 more source

Glutamine metabolism in the rat [PDF]

FEBS Letters, 1980
1 .I. Glutaminase isoenzymes (EC 3.5.1.2) In his paper, entitled, ‘The synthesis of glutamine from glutamjc acid and ammonia, and the enzymic hydrolysis of glutamine in animal tissues’ published 4.5 years ago [l], H. A. Krebs perceptively recognized: ‘there are at least two types of glutaminase distinguishable by their pH optima and their inhibitions ...
openaire   +2 more sources

Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease

Neurobiology of Disease, 2021
Alzheimer's disease (AD) leads to cerebral accumulation of insoluble amyloid-β plaques causing synaptic dysfunction and neuronal death. Neurons rely on astrocyte-derived glutamine for replenishment of the amino acid neurotransmitter pools.
Jens V. Andersen, Sofie K. Christensen, Emil W. Westi, Marta Diaz-delCastillo, Heikki Tanila, Arne Schousboe, Blanca I. Aldana, Helle S. Waagepetersen   +7 more
doaj   +1 more source

Randomised trial of glutamine and selenium supplemented parenteral nutrition for critically ill patients [PDF]

, 2007
Background: Mortality rates in the Intensive Care Unit and subsequent hospital mortality rates in the UK remain high. Infections in Intensive Care are associated with a 2–3 times increased risk of death.
Vale, Luke D, Campbell, MK, Cook, Jonathan Alistair, Simpson, William G., Cook Jonathon, Battison, CG, Cook, J, Milne, AC, Andrews, Peter J.D., Campbell, Marion K, Vale, LD, Peter JD Andrews, Trials Management Group, Andrews, Peter J D, Croal, BL, Battison, Claire G., Milne Anne C, Simpson William G, De Verteuil, Robyn, de Verteuil Robyn, William G Simpson, Anne C Milne, ?, ?, Norrie, John David, Avenell, A, null null, Noble, David W., Milne, Anne C, Vale Luke D, Noble David W, Vale, Luke David, Campbell, Marion Kay, Norrie, John, Claire G Battison, Simpson, William G, Andrews, PJD, Avenell Alison, Robyn de Verteuil, Cook, Jonathon, Croal, Bernard L., de Verteuil, R, Jonathon Cook, Battison Claire G, Campbell Marion K, Bernard L Croal, Norrie John, Noble, David W, Croal, Bernard L, David W Noble, John Norrie, Andrews Peter JD, Noble, DW, Alison Avenell, Marion K Campbell, Croal Bernard L, Simpson, WG, Norrie, J, Avenell, Alison, Battison, Claire G, Milne, Anne Catherine, Luke D Vale   +60 more
core   +2 more sources

Aminosäuren – Leitlinie Parenterale Ernährung, Kapitel 4 [PDF]

, 2009
Protein catabolism should be reduced and protein synthesis promoted with parenteral nutrion (PN). Amino acid (AA) solutions should always be infused with PN. Standard AA solutions are generally used, whereas specially adapted AA solutions may be required
Blumenstein, I, Stein, J, Goeters, C, Working group for developing the guidelines for parenteral nutrition of The German Association for Nutritional Medicine, Schulz, R., Boehles, HJ, Blumenstein, I., Schulz, R, Blumenstein, Irina Ursula, Goeters, Christiane, Boehles, H. J., Goeters, C., Böhles, Hansjosef, Stein, Jürgen, Schulz, Ralf-Joachim, Stein, J.   +15 more
core   +1 more source

Glutamine metabolism modulates chondrocyte inflammatory response [PDF]

, 2022
Osteoarthritis is the most common joint disease in the world with significant societal consequences but lacks effective disease-modifying interventions.
Mbalaviele, Gabriel, Yousef Abu-Amer, Cai, Lei, Brophy, Robert, Syeda Kanwal Naqvi, Adapala, Naga Suresh, Gabriel Mbalaviele, Arra, Manoj, Robert Brophy, Srikanth Singamaneni, Muhammad Farooq Rai, Gaurav Swarnkar, Naga Suresh Adapala, Lei Cai, Abu-Amer, Yousef, Swarnkar, Gaurav, Manoj Arra, Rai, Muhammad Farooq, Naqvi, Syeda Kanwal, Farooq Rai, Muhammad, Singamaneni, Srikanth   +20 more
core   +1 more source