Results 31 to 40 of about 1,150,143 (287)

Glutamate dehydrogenase 1-dependent α-ketoglutarate promotes hepatitis B virus transcription by modulating histone methylations on the covalently closed circular DNA minichromosome [PDF]

Clinical and Molecular Hepatology
Background/Aims Hepatitis B virus (HBV) hijacks host cell metabolism, especially host glutamine metabolism, to support its replication. Glutamate dehydrogenase 1 (GDH1), a mitochondrial enzyme crucial for glutamine metabolism, can interact with histone ...
Sheng-Tao Cheng, Wei-Xian Chen, Hai-Jun Deng, Xin He, Hui Zhang, Ming Tan, Hai-Bo Yu, Zhen-Zhen Zhang, Ji-Hua Ren, Min-Li Yang, Da-Peng Zhang, Zhi-Hong Li, Juan Chen   +12 more
doaj   +1 more source

Targeting Glutamine Metabolism in Prostate Cancer

Frontiers in Bioscience-Elite, 2023
Glutamine is a conditionally essential amino acid important for cancer cell proliferation through intermediary metabolism leading to de novo synthesis of purine and pyrimidine nucleotides, hexosamine biosytnehsis, fatty acid synthesis through reductive ...
Neil Bhowmick, Edwin Posadas, Leigh Ellis, Stephen J Freedland, Dolores Di Vizio, Michael R Freeman, Dan Theodorescu, Robert Figlin, Jun Gong   +8 more
doaj   +1 more source

Glutamine in critical care:current evidence from systematic reviews [PDF]

, 2006
Glutamine, the most abundant amino acid in the body, is thought to become conditionally essential in critical illness. Some of the important roles for glutamine are as a carrier for inter-organ N, a preferred fuel for enterocytes and cells of the immune ...
Avenell, Alison, Alison Avenell
core   +1 more source

GOLM1 Stimulation of Glutamine Metabolism Promotes Osteoporosis via Inhibiting Osteogenic Differentiation of BMSCs

Cellular Physiology and Biochemistry, 2018
Background/Aims: Bone marrow mesenchymal stem cells (BMSCs) play an essential role in osteoporosis. However, the molecular mechanisms and the involvement of glutamine metabolism in osteogenic BMSCs differentiation and osteoporosis remain largely unclear.
Guangsi Shen, Hong Zhang, Peng Jia, Guangfei Li, Xiao Wang, Xiaozhong Zhou, Youjia Xu   +6 more
doaj   +1 more source

Inhibition of lncRNA NEAT1 induces dysfunction of fibroblast-like synoviocytes in rheumatoid arthritis via miRNA-338-3p-mediated regulation of glutamine metabolism

Journal of Orthopaedic Surgery and Research, 2022
Background Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease; cellular glutamine metabolism in fibroblast-like synoviocytes (FLSs) of RA was known to be essential for RA pathogenesis and progression.
Mei Zhang, Ning Lu, Hong-Jun Li, Xiao-Yun Guo, Lu Lu, Ying Guo   +5 more
doaj   +1 more source

Alanine, glutamine and glutamate metabolism–non-mitochondrial version.

, 2022
Alanine, glutamine and glutamate metabolism–non-mitochondrial version.
Morten Beck Rye (14009114), Finn Drabløs (31753), Kjersti Rise (3523298), May-Britt Tessem (406107)   +3 more
core   +1 more source

Increased Ammonium Toxicity in Response to Exogenous Glutamine in Metastatic Breast Cancer Cells

Metabolites, 2022
Several cancers, including breast cancers, show dependence on glutamine metabolism. The purpose of the present study was to determine the mechanistic basis and impact of differential glutamine metabolism in nonmetastatic and metastatic murine mammary ...
Violet A. Kiesel, Madeline P. Sheeley, Shawn S. Donkin, Michael K. Wendt, Stephen D. Hursting, Dorothy Teegarden   +5 more
doaj   +1 more source

Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease

Neurobiology of Disease, 2021
Alzheimer's disease (AD) leads to cerebral accumulation of insoluble amyloid-β plaques causing synaptic dysfunction and neuronal death. Neurons rely on astrocyte-derived glutamine for replenishment of the amino acid neurotransmitter pools.
Jens V. Andersen, Sofie K. Christensen, Emil W. Westi, Marta Diaz-delCastillo, Heikki Tanila, Arne Schousboe, Blanca I. Aldana, Helle S. Waagepetersen   +7 more
doaj   +1 more source

A ketogenic diet sensitizes pancreatic cancer to glutamine metabolism inhibitors. [PDF]

Cell Rep Med
Attached below are the metabolomics and RNA-sequencing datasets associated with the manuscript titled ‘A Ketogenic Diet Sensitizes Pancreatic Cancer to Glutamine Metabolism ...
Hajihassani O, Roichman A, Boyer JA, MacArthur M, Cordova R, Loftus A, Boutros CS, Hue JJ, Naji P, Tahhan S, Gallagher P, Beegan W, Shah D, Choi J, Manzoor N, Lei S, Kim C, Rathore M, Shah I, Lebo K, Cheng H, Mudigonda A, Hunter C, Zarei M, Alibeckoff S, Ji K, Graor H, Miyagi M, Vaziri-Gohar A, Brunengraber H, Wang R, Lund PJ, Rothermel LD, Rabinowitz JD, Winter JM.   +34 more
europepmc   +2 more sources

Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism.

PLoS ONE, 2017
Liver fibrosis is the excessive accumulation of extracellular matrix proteins, which is mainly caused by accumulation of activated hepatic stellate cells (HSCs).
Jiang Li, Mohammed Ghazwani, Ke Liu, Yixian Huang, Na Chang, Jie Fan, Fengtian He, Liying Li, Shizhong Bu, Wen Xie, Xiaochao Ma, Song Li   +11 more
doaj   +1 more source