Results 31 to 40 of about 184,210 (258)
Cells, 2022 Glutamine metabolism is critical both for the proliferation of cancer cells and the activation of CD8T cells to kill cancer cells. We aim to explore the relationship between the glutamine metabolism of CD8T cells and cancer cells and tumor immunity in ...
Jianfei Chen +8 more
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Glutamine metabolism in the rat [PDF]
FEBS Letters, 1980 1 .I. Glutaminase isoenzymes (EC 3.5.1.2) In his paper, entitled, ‘The synthesis of glutamine from glutamjc acid and ammonia, and the enzymic hydrolysis of glutamine in animal tissues’ published 4.5 years ago [l], H. A. Krebs perceptively recognized: ‘there are at least two types of glutaminase distinguishable by their pH optima and their inhibitions ...
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Targeting Glutamine Metabolism in Prostate Cancer
Frontiers in Bioscience-Elite, 2023 Glutamine is a conditionally essential amino acid important for cancer cell proliferation through intermediary metabolism leading to de novo synthesis of purine and pyrimidine nucleotides, hexosamine biosytnehsis, fatty acid synthesis through reductive ...
Neil Bhowmick +8 more
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Glutamate dehydrogenase 1-dependent α-ketoglutarate promotes hepatitis B virus transcription by modulating histone methylations on the covalently closed circular DNA minichromosome [PDF]
Clinical and Molecular HepatologyBackground/Aims Hepatitis B virus (HBV) hijacks host cell metabolism, especially host glutamine metabolism, to support its replication. Glutamate dehydrogenase 1 (GDH1), a mitochondrial enzyme crucial for glutamine metabolism, can interact with histone ...
Sheng-Tao Cheng +12 more
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Journal of Orthopaedic Surgery and Research, 2022 Background Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease; cellular glutamine metabolism in fibroblast-like synoviocytes (FLSs) of RA was known to be essential for RA pathogenesis and progression.
Mei Zhang +5 more
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Glutamine Metabolism Is Required for Alveolar Regeneration during Lung Injury
Biomolecules, 2022 (1) Background: Abnormal repair after alveolar epithelial injury drives the progression of idiopathic pulmonary fibrosis (IPF). The maintenance of epithelial integrity is based on the self-renewal and differentiation of alveolar type 2 (AT2) cells, which
Sisi Wang +12 more
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Increased Ammonium Toxicity in Response to Exogenous Glutamine in Metastatic Breast Cancer Cells
Metabolites, 2022 Several cancers, including breast cancers, show dependence on glutamine metabolism. The purpose of the present study was to determine the mechanistic basis and impact of differential glutamine metabolism in nonmetastatic and metastatic murine mammary ...
Violet A. Kiesel +5 more
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Neurobiology of Disease, 2021 Alzheimer's disease (AD) leads to cerebral accumulation of insoluble amyloid-β plaques causing synaptic dysfunction and neuronal death. Neurons rely on astrocyte-derived glutamine for replenishment of the amino acid neurotransmitter pools.
Jens V. Andersen +7 more
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Cellular Physiology and Biochemistry, 2018 Background/Aims: Bone marrow mesenchymal stem cells (BMSCs) play an essential role in osteoporosis. However, the molecular mechanisms and the involvement of glutamine metabolism in osteogenic BMSCs differentiation and osteoporosis remain largely unclear.
Guangsi Shen +6 more
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Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism.
PLoS ONE, 2017 Liver fibrosis is the excessive accumulation of extracellular matrix proteins, which is mainly caused by accumulation of activated hepatic stellate cells (HSCs).
Jiang Li +11 more
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