Results 21 to 30 of about 318,213 (301)
Cells, 2022 Glutamine metabolism is critical both for the proliferation of cancer cells and the activation of CD8T cells to kill cancer cells. We aim to explore the relationship between the glutamine metabolism of CD8T cells and cancer cells and tumor immunity in ...
Jianfei Chen +8 more
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Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells [PDF]
, 2015 BRAF inhibitors can extend progression-free and overall survival in melanoma patients whose tumors harbor mutations in BRAF. However, the majority of patients eventually develop resistance to these drugs. Here we show that BRAF mutant melanoma cells that
Baenke, Franziska +12 more
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Glutamine reliance in cell metabolism [PDF]
Experimental & Molecular Medicine, 2020 AbstractAs knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial glutamine metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the emergence of drug ...
Hee Chan Yoo +3 more
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Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. [PDF]
, 2017 Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of ...
Bordbar, Aarash +5 more
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Glutamine metabolism in the rat [PDF]
FEBS Letters, 1980 1 .I. Glutaminase isoenzymes (EC 3.5.1.2) In his paper, entitled, ‘The synthesis of glutamine from glutamjc acid and ammonia, and the enzymic hydrolysis of glutamine in animal tissues’ published 4.5 years ago [l], H. A. Krebs perceptively recognized: ‘there are at least two types of glutaminase distinguishable by their pH optima and their inhibitions ...
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Targeting Glutamine Metabolism in Prostate Cancer
Frontiers in Bioscience-Elite, 2023 Glutamine is a conditionally essential amino acid important for cancer cell proliferation through intermediary metabolism leading to de novo synthesis of purine and pyrimidine nucleotides, hexosamine biosytnehsis, fatty acid synthesis through reductive ...
Neil Bhowmick +8 more
doaj +1 more source
Astrocyte glutamine synthetase : pivotal in health and disease [PDF]
, 2013 The multifunctional properties of astrocytes signify their importance in brain physiology and neurological function. In addition to defining the brain architecture, astrocytes are primary elements of brain ion, pH and neurotransmitter homoeostasis.
Parpura, Vladimir +2 more
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Glutamate dehydrogenase 1-dependent α-ketoglutarate promotes hepatitis B virus transcription by modulating histone methylations on the covalently closed circular DNA minichromosome [PDF]
Clinical and Molecular HepatologyBackground/Aims Hepatitis B virus (HBV) hijacks host cell metabolism, especially host glutamine metabolism, to support its replication. Glutamate dehydrogenase 1 (GDH1), a mitochondrial enzyme crucial for glutamine metabolism, can interact with histone ...
Sheng-Tao Cheng +12 more
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Glutamine Metabolism Is Required for Alveolar Regeneration during Lung Injury
Biomolecules, 2022 (1) Background: Abnormal repair after alveolar epithelial injury drives the progression of idiopathic pulmonary fibrosis (IPF). The maintenance of epithelial integrity is based on the self-renewal and differentiation of alveolar type 2 (AT2) cells, which
Sisi Wang +12 more
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Journal of Orthopaedic Surgery and Research, 2022 Background Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease; cellular glutamine metabolism in fibroblast-like synoviocytes (FLSs) of RA was known to be essential for RA pathogenesis and progression.
Mei Zhang +5 more
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