Response of glutamine metabolism to glutamine-supplemented parenteral nutrition [PDF]
The American Journal of Clinical Nutrition, 2000 Increasing evidence suggests that glutamine is important for the function of many organ systems and supports the use of glutamine-enriched total parenteral nutrition (TPN) during severe illness. However, the effect of prolonged glutamine supplementation on glutamine kinetics has not been studied.We investigated the effect of 8-10 d of TPN enriched with
van Acker, B.A.C. +4 more
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Glutamine Metabolism Is Required for Alveolar Regeneration during Lung Injury
Biomolecules, 2022 (1) Background: Abnormal repair after alveolar epithelial injury drives the progression of idiopathic pulmonary fibrosis (IPF). The maintenance of epithelial integrity is based on the self-renewal and differentiation of alveolar type 2 (AT2) cells, which
Sisi Wang +12 more
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RHOJ derived peptide promotes chemosensitivity by inhibiting glutamine metabolism in gastric cancer [PDF]
Journal of Translational MedicineBackground Chemoresistance is a cause of chemotherapy failure in gastric cancer (GC) treatment. Recent studies have shown that the dysregulation of glutamine metabolism plays a pivotal role in promoting chemoresistance.
Jian Li +8 more
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ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression [PDF]
Cell DiscoveryS-palmitoylation, a reversible post-translational modification regulates protein stability and cellular functions, yet its role in glutamine metabolism remains unclear.
Xingyu Chen +14 more
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Frontiers in PharmacologyCancer cells have adapted to rapid tumor growth and evade immune attack by reprogramming their metabolic pathways. Glutamine is an important nitrogen resource for synthesizing amino acids and nucleotides and an important carbon source in the ...
Yuxin Fan +9 more
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RUNX2 enhances bladder cancer progression by promoting glutamine metabolism
Neoplasia: An International Journal for Oncology ResearchBladder cancer is a prevalent malignancy within the urinary system. Prior research has suggested that glutamine metabolism plays a crucial role in driving bladder cancer progression. However, the precise molecular mechanism governing glutamine metabolism
Zhigang Huang +7 more
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Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases [PDF]
MedCommGlutaminolysis, the metabolic process of converting glutamine into key intermediates, plays an essential role in cellular energy production, signaling, biosynthesis, and redox balance. Deregulation of glutamine metabolism significantly influences various
Mudasir A. Kumar +10 more
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Targeting glutamine metabolism as a potential target for cancer treatment [PDF]
Journal of Experimental & Clinical Cancer ResearchMetabolic reprogramming is a hallmark of cancer cells, and the advent of “glutamine addiction” in numerous tumors signifies a pivotal advancement for precision-targeted therapy.
Wenxuan Zou +3 more
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Glutamine metabolic reprogramming in hepatocellular carcinoma
Frontiers in Molecular Biosciences, 2023 Hepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including glutamine metabolic reprogramming.
Yanyan Ye +6 more
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Integrated analysis of glutamine metabolism and immune microenvironment identifies GOT2 as a prognostic gene in head and neck squamous cell carcinoma [PDF]
Discover OncologyGlutamine metabolism plays a key role in cancer initiation and progression. This study aims to explore the independent and interactive roles of glutamine metabolism-related genes and immune characteristic in head and neck squamous cell carcinoma (HNSCC).
Xikong Pan +3 more
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