Results 1 to 10 of about 20,010 (192)

SCREENING AND CHARACTERIZATION OF L-GLUTAMINASE PRODUCED BY BACTERIA ISOLATED FROM SANGIHE TALAUD SEA [PDF]

Squalen, 2013
L-glutaminase (L-glutamine amidohydrolase, EC 3.5.1.2) is a very important enzyme due to its role as flavor enhancer and antileukemic agent. Salt-tolerant L-glutaminase produced by marine bacteria is favorable in food industries. This study describes the
Ekowati Chasanah, Usman Sumo Friend Tambunan, Tanti Yulianti   +2 more
doaj   +2 more sources

MicroRNA-153 regulates glutamine metabolism in glioblastoma through targeting glutaminase

Tumor Biology, 2017
Glioblastoma is the most aggressive manifestation of malignant gliomas and considered to be among the deadliest forms of human cancers. MicroRNAs are found to tightly regulate diverse biological processes and considered to play important roles in cancer ...
Zhenyang Liu, Junyu Wang, Yunjun Li, Juan Fan, Lihua Chen, Ruxiang Xu   +5 more
doaj   +2 more sources

Structural reassignment of compound 968, an allosteric glutaminase inhibitor [PDF]

Beilstein Journal of Organic Chemistry
Many cancer cells require extracellular glutamine to meet the energetic, biosynthetic, and redox demands of the proliferative state. Glutaminases catalyze the hydrolysis of glutamine to glutamate, which supports the biosynthesis of amino acids, lipids ...
Lindsey A. Albertelli, Sainabou Jallow, Chun Li, Scott M. Ulrich   +3 more
doaj   +2 more sources

Rapid Screening of Cultural Parameters for Extracellular Halophilic Glutaminase Production from Tetragenococcus Muriaticus FF5302 using the Plackett-Burman’s Experimental Design

Walailak Journal of Science and Technology, 2021
The Plackett-Burman’s experiemental design was used to efficiently select the key cultural parameters for the production of halophilic glutaminase by moderating halophilic bacterium Tetragenococcus muriaticus FF5302.
Sawitree DUERAMAE, Patthinan VARICHANAN, Toshiki ENOMOTO   +2 more
doaj   +3 more sources

Immunogenicity assessment of antileukemic agent glutaminase from Escherichia coli, Pseudomonas sp., and Bacillus sp.

Biomedical and Biotechnology Research Journal, 2022
Background: L-glutaminase (L-glutaminase or glutamine amidohydrolase: EC 3.5.1.2) is an antileukemic agent which catalyzes the deamidation of glutamine to glutamic acid and ammonia.
Jyotsna Parmar, Shikha Tripathi, Awanish Kumar   +2 more
doaj   +1 more source

Loss of mammalian glutaminase orthologs impairs sperm function in Caenorhabditis elegans

iScience, 2023
Summary: The decline in sperm function is a major cause of human male infertility. Glutaminase, a mitochondrial enzyme that catalyzes the hydrolysis of glutamine to generate glutamate, takes part in many diverse biological processes such as ...
Qifei Liang, Haiyan Yang, Zhifei Zhang, Jialin C. Zheng, Zhao Qin   +4 more
doaj   +1 more source

High-Throughput Screening Reveals New Glutaminase Inhibitor Molecules

, 2021
The glutaminase (GLS) enzyme hydrolyzes glutamine into glutamate, an important anaplerotic source for the tricarboxylic acid cycle in rapidly growing cancer cells under the Warburg effect.
Cyro von Zuben de Valega Negrao (11777403), Kaliandra de Almeida Gonçalves (11777406), Carolline F. R. Ascenção (11777409), Fernanda A. H. Batista (8441244), Luciana S. Paradela (11777394), Gustavo Fernando Mercaldi (11777412), Andre L. B. Ambrosio (11777421), Rafael V. C. Guido (4557034), Bianca Novaes da Silva (11777400), Camila T. Rodrigues (11777388), Sandra M. G. Dias (11777424), Alliny C. S. Bastos (11777415), Renna K. E. Costa (11777385), Jean C. H. Campos (11777391), Marilia M. Dias (11777397), Artur T. Cordeiro (5512295), Douglas Adamoski (4578661), Ana Carolina Figueira (11777418)   +17 more
core   +2 more sources

Dendritic Cell α-Ketoglutarate Regulates Tfh Polarization in Allergy. [PDF]

Allergy
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Tharakan A, Qu X, Camarena C, Abaidoo-Myles A, Naik P, Allegood J, Kumar A, Pokhriyal M, Lownik JC, Zellner MP, Way GW, Liu J, Cowart LA, Eisenbarth SC, Landry JW, Conrad DH, Martin RK.   +16 more
europepmc   +2 more sources

The Role Of Glutaminase In Cancer [PDF]

, 2020
Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised as a key metabolic change in cancer cells. As a heterogeneous disease with different morpholog- ical and molecular subtypes and response to therapy, breast cancer ...
Craze, Madeleine, Madeleine L Craze, Masisi, Brendah, El Ansari, Rokaya, Green, Andrew, Emad A Rakha, Rakha, Emad, Brendah K Masisi, Lutfi Alfarsi, Andrew R Green, Alfarsi, Lutfi, Rokaya El Ansari   +11 more
core   +1 more source

Interferon-α regulates glutaminase 1 promoter through STAT1 phosphorylation: relevance to HIV-1 associated neurocognitive disorders. [PDF]

PLoS ONE, 2012
HIV-1 associated neurocognitive disorders (HAND) develop during progressive HIV-1 infection and affect up to 50% of infected individuals. Activated microglia and macrophages are critical cell populations that are involved in the pathogenesis of HAND ...
Lixia Zhao, Yunlong Huang, Changhai Tian, Lynn Taylor, Norman Curthoys, Yi Wang, Hamilton Vernon, Jialin Zheng   +7 more
doaj   +1 more source