Results 1 to 10 of about 19,538 (222)
The role of glutaminase in cancer [PDF]
Histopathology, 2020 Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised as a key metabolic change in cancer cells. Breast cancer is a heterogeneous disease with different morphological and molecular subtypes and responses to therapy, and breast cancer cells are known to rewire glutamine metabolism to support survival and proliferation.
Andrew Green +2 more
exaly +5 more sources
Biomolecular Concepts, 2010 Glutaminase is considered as the main glutamate producer enzyme in brain. Consequently, the enzyme is essential for both glutamatergic and gabaergic transmissions.
Márquez Javier +5 more
doaj +3 more sources
Dendritic Cell α-Ketoglutarate Regulates Tfh Polarization in Allergy. [PDF]
AllergyAllergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Tharakan A +16 more
europepmc +2 more sources
Interferon-α regulates glutaminase 1 promoter through STAT1 phosphorylation: relevance to HIV-1 associated neurocognitive disorders. [PDF]
PLoS ONE, 2012 HIV-1 associated neurocognitive disorders (HAND) develop during progressive HIV-1 infection and affect up to 50% of infected individuals. Activated microglia and macrophages are critical cell populations that are involved in the pathogenesis of HAND ...
Lixia Zhao +7 more
doaj +3 more sources
Structural reassignment of compound 968, an allosteric glutaminase inhibitor [PDF]
Beilstein Journal of Organic ChemistryMany cancer cells require extracellular glutamine to meet the energetic, biosynthetic, and redox demands of the proliferative state. Glutaminases catalyze the hydrolysis of glutamine to glutamate, which supports the biosynthesis of amino acids, lipids ...
Lindsey A. Albertelli +3 more
doaj +2 more sources
miR-15a-5p Regulates Ferroptosis in Glioblastoma by Targeting GLS2. [PDF]
CNS Neurosci TherSchematic diagram of the mechanism by which miR‐15a‐5p regulates glioblastoma progression through targeting GLS2 and modulating ferroptosis. miR‐15a‐5p regulates the ferroptosis pathway by targeting and inhibiting glutaminase 2 (GLS2) expression: Downregulation of miR‐15a‐5p leads to upregulation of GLS2, which promotes lipid peroxidation, accompanied ...
Yu Y +7 more
europepmc +2 more sources
Walailak Journal of Science and Technology, 2021 The Plackett-Burman’s experiemental design was used to efficiently select the key cultural parameters for the production of halophilic glutaminase by moderating halophilic bacterium Tetragenococcus muriaticus FF5302.
Sawitree DUERAMAE +2 more
doaj +3 more sources
Biomedical and Biotechnology Research Journal, 2022 Background: L-glutaminase (L-glutaminase or glutamine amidohydrolase: EC 3.5.1.2) is an antileukemic agent which catalyzes the deamidation of glutamine to glutamic acid and ammonia.
Jyotsna Parmar +2 more
doaj +1 more source
Loss of mammalian glutaminase orthologs impairs sperm function in Caenorhabditis elegans
iScience, 2023 Summary: The decline in sperm function is a major cause of human male infertility. Glutaminase, a mitochondrial enzyme that catalyzes the hydrolysis of glutamine to generate glutamate, takes part in many diverse biological processes such as ...
Qifei Liang +4 more
doaj +1 more source
Frontiers in Oncology, 2020 Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis, tumor growth, and the production of antioxidants through glutaminolysis in ...
Zhefang Wang +9 more
doaj +1 more source