Results 1 to 10 of about 15,764 (116)
Biochemical and biological evaluation of L-glutaminase from Aspergillus tamarii AUMC 10198 via solid-state fermentation [PDF]
Microbial Cell FactoriesIntroduction Fungal L-glutaminase has recently attracted growing interest due to its potential applications in medical therapy and biotechnology. This study aimed to develop a cost-effective bioprocess for L-glutaminase production using agricultural by ...
Ghada A. Youssef +3 more
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Structural reassignment of compound 968, an allosteric glutaminase inhibitor [PDF]
Beilstein Journal of Organic ChemistryMany cancer cells require extracellular glutamine to meet the energetic, biosynthetic, and redox demands of the proliferative state. Glutaminases catalyze the hydrolysis of glutamine to glutamate, which supports the biosynthesis of amino acids, lipids ...
Lindsey A. Albertelli +3 more
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Glutaminase Expression in Canine Large‐Cell Alimentary Lymphoma Cells and Effects of Glutaminase Inhibition by CB‐839 [PDF]
Veterinary Medicine and ScienceGlutamine metabolism plays a crucial role in tumour progression, making glutaminase a promising therapeutic target in various human cancers. However, its role in canine large‐cell alimentary lymphoma (AL) remains unclear.
Kosei Sakai +5 more
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Walailak Journal of Science and Technology, 2021 The Plackett-Burman’s experiemental design was used to efficiently select the key cultural parameters for the production of halophilic glutaminase by moderating halophilic bacterium Tetragenococcus muriaticus FF5302.
Sawitree DUERAMAE +2 more
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Biomedical and Biotechnology Research Journal, 2022 Background: L-glutaminase (L-glutaminase or glutamine amidohydrolase: EC 3.5.1.2) is an antileukemic agent which catalyzes the deamidation of glutamine to glutamic acid and ammonia.
Jyotsna Parmar +2 more
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Loss of mammalian glutaminase orthologs impairs sperm function in Caenorhabditis elegans
iScience, 2023 Summary: The decline in sperm function is a major cause of human male infertility. Glutaminase, a mitochondrial enzyme that catalyzes the hydrolysis of glutamine to generate glutamate, takes part in many diverse biological processes such as ...
Qifei Liang +4 more
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Interferon-α regulates glutaminase 1 promoter through STAT1 phosphorylation: relevance to HIV-1 associated neurocognitive disorders. [PDF]
PLoS ONE, 2012 HIV-1 associated neurocognitive disorders (HAND) develop during progressive HIV-1 infection and affect up to 50% of infected individuals. Activated microglia and macrophages are critical cell populations that are involved in the pathogenesis of HAND ...
Lixia Zhao +7 more
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Frontiers in Oncology, 2020 Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis, tumor growth, and the production of antioxidants through glutaminolysis in ...
Zhefang Wang +9 more
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Metformin inhibits glutaminase activity and protects against hepatic encephalopathy. [PDF]
PLoS ONE, 2012 AIM: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients.
Javier Ampuero +10 more
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TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase
Journal of Neuroinflammation, 2017 Background Extracellular vesicles (EVs) are membrane-contained vesicles shed from cells. EVs contain proteins, lipids, and nucleotides, all of which play important roles in intercellular communication.
Kaizhe Wang +6 more
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