Biomolecular Concepts, 2010 Glutaminase is considered as the main glutamate producer enzyme in brain. Consequently, the enzyme is essential for both glutamatergic and gabaergic transmissions.
Márquez Javier +5 more
doaj +3 more sources
THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy. [PDF]
PLoS ONE, 2014 Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity the main source for ammonia.
M Mar Díaz-Herrero +8 more
doaj +4 more sources
The Glutaminase-Dependent System Confers Extreme Acid Resistance to New Species and Atypical Strains of Brucella [PDF]
Frontiers in Microbiology, 2017 Neutralophilic bacteria have developed specific mechanisms to cope with the acid stress encountered in environments such as soil, fermented foods, and host compartments. In Escherichia coli, the glutamate decarboxylase (Gad)-dependent system is extremely
Luca Freddi +7 more
doaj +7 more sources
Biochemical and biological evaluation of L-glutaminase from Aspergillus tamarii AUMC 10198 via solid-state fermentation [PDF]
Microbial Cell FactoriesIntroduction Fungal L-glutaminase has recently attracted growing interest due to its potential applications in medical therapy and biotechnology. This study aimed to develop a cost-effective bioprocess for L-glutaminase production using agricultural by ...
Ghada A. Youssef +3 more
doaj +2 more sources
Glutaminase Expression in Canine Large‐Cell Alimentary Lymphoma Cells and Effects of Glutaminase Inhibition by CB‐839 [PDF]
Veterinary Medicine and ScienceGlutamine metabolism plays a crucial role in tumour progression, making glutaminase a promising therapeutic target in various human cancers. However, its role in canine large‐cell alimentary lymphoma (AL) remains unclear.
Kosei Sakai +5 more
doaj +2 more sources
Anticancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) capped silver and zinc oxide nanoparticles and its molecular characterization [PDF]
Bioresources and BioprocessingThe current investigation reports anti-cancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) and L-Glutaminase capped nanoparticles.
Zabin K. Bagewadi +4 more
doaj +2 more sources
eLifeThe breakdown of glutamine is an important metabolic pathway for the health and survival of rod photoreceptors within the retina.
Katherine J Wert
doaj +2 more sources
Biomedical and Biotechnology Research Journal, 2022 Background: L-glutaminase (L-glutaminase or glutamine amidohydrolase: EC 3.5.1.2) is an antileukemic agent which catalyzes the deamidation of glutamine to glutamic acid and ammonia.
Jyotsna Parmar +2 more
doaj +1 more source
Loss of mammalian glutaminase orthologs impairs sperm function in Caenorhabditis elegans
iScience, 2023 Summary: The decline in sperm function is a major cause of human male infertility. Glutaminase, a mitochondrial enzyme that catalyzes the hydrolysis of glutamine to generate glutamate, takes part in many diverse biological processes such as ...
Qifei Liang +4 more
doaj +1 more source
Walailak Journal of Science and Technology, 2021 The Plackett-Burman’s experiemental design was used to efficiently select the key cultural parameters for the production of halophilic glutaminase by moderating halophilic bacterium Tetragenococcus muriaticus FF5302.
Sawitree DUERAMAE +2 more
doaj +1 more source