Results 11 to 20 of about 24,633 (278)
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2019 After metabolic reprogramming, many cancer cells become glutamine addicted, that is, they depend on a high consumption of this amino acid for their survival and proliferation. Glutaminase catalyzes the stoichiometric conversion of L-glutamine to L-glutamate and ammonium ions, the first step of glutaminolysis.
Campos-Sandoval, José A. +2 more
openaire +3 more sources
Application Prospect of Protein-Glutaminase in the Development of Plant-Based Protein Foods
Foods, 2022 Plant-based protein foods as suitable alternative protein sources have recently received increased global interest. The scientific community is exploring effective modification approaches to enhance the functionality of plant-based proteins for expanded ...
Xiao Liu +5 more
doaj +2 more sources
Metformin inhibits glutaminase activity and protects against hepatic encephalopathy. [PDF]
PLoS ONE, 2012 AIM: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients.
Javier Ampuero +10 more
doaj +3 more sources
Production, characterization, and antitumor efficiency of l-glutaminase from halophilic bacteria
Bulletin of the National Research Centre, 2022 Background Halophiles are an excellent source of enzymes that are not only salt stable, but also can withstand and carry out reaction efficiently under extreme conditions.
Eman Zakaria Gomaa
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Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma
Clinical and Translational Medicine, 2022 Background Glutaminolysis is a critical metabolic process that promotes cancer cell proliferation, including hepatocellular carcinoma (HCC). Delineating the molecular control of glutaminolysis could identify novel targets to ameliorate this oncogenic ...
Taotao Zhang +14 more
doaj +2 more sources
Biology, 2023 Simple Summary Many types of cancer cells utilize the common amino acid l-glutamine to maintain their metabolic demands for energy and the nitrogen required for DNA synthesis.
A. Cooper, T. Dorai, J. Pinto, T. Denton
semanticscholar +2 more sources
HuR controls glutaminase RNA metabolism
Nature CommunicationsGlutaminase (GLS) is directly related to cell growth and tumor progression, making it a target for cancer treatment. The RNA-binding protein HuR (encoded by the ELAVL1 gene) influences mRNA stability and alternative splicing.
Douglas Adamoski +7 more
semanticscholar +3 more sources
Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health [PDF]
Nature MetabolismGlutamine and glutamate are interconverted by several enzymes and alterations in this metabolic cycle are linked to cardiometabolic traits. Herein, we show that obesity-associated insulin resistance is characterized by decreased plasma and white adipose ...
Simon Lecoutre +29 more
semanticscholar +2 more sources
MicroRNA-153 regulates glutamine metabolism in glioblastoma through targeting glutaminase
Tumor Biology, 2017 Glioblastoma is the most aggressive manifestation of malignant gliomas and considered to be among the deadliest forms of human cancers. MicroRNAs are found to tightly regulate diverse biological processes and considered to play important roles in cancer ...
Zhenyang Liu +5 more
doaj +2 more sources
Squalen, 2013 L-glutaminase (L-glutamine amidohydrolase, EC 3.5.1.2) is a very important enzyme due to its role as flavor enhancer and antileukemic agent. Salt-tolerant L-glutaminase produced by marine bacteria is favorable in food industries. This study describes the
Ekowati Chasanah +2 more
doaj +3 more sources