Results 11 to 20 of about 15,841 (191)
Biomolecular Concepts, 2010 Glutaminase is considered as the main glutamate producer enzyme in brain. Consequently, the enzyme is essential for both glutamatergic and gabaergic transmissions.
Márquez Javier +5 more
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Production, characterization, and antitumor efficiency of l-glutaminase from halophilic bacteria
Bulletin of the National Research Centre, 2022 Background Halophiles are an excellent source of enzymes that are not only salt stable, but also can withstand and carry out reaction efficiently under extreme conditions.
Eman Zakaria Gomaa
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THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy. [PDF]
PLoS ONE, 2014 Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity the main source for ammonia.
M Mar Díaz-Herrero +8 more
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Application Prospect of Protein-Glutaminase in the Development of Plant-Based Protein Foods
Foods, 2022 Plant-based protein foods as suitable alternative protein sources have recently received increased global interest. The scientific community is exploring effective modification approaches to enhance the functionality of plant-based proteins for expanded ...
Xiao Liu +5 more
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Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma
Clinical and Translational Medicine, 2022 Background Glutaminolysis is a critical metabolic process that promotes cancer cell proliferation, including hepatocellular carcinoma (HCC). Delineating the molecular control of glutaminolysis could identify novel targets to ameliorate this oncogenic ...
Taotao Zhang +14 more
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Research Progress in Improving Efficacy of Radiotherapy by Targeting Glutamine Metabolism
Zhongliu Fangzhi Yanjiu, 2023 Radiotherapy is an important treatment method for malignant tumors. Radiation resistance is the main obstacle to the therapeutic effect of radiotherapy. Cellular metabolic reprogramming is one of the main features of cancer, and it may have an important ...
QIAO Wanjia, DONG Na, LIU Xiaojun
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Molecules, 2019 In this study, the Micrococcus luteus K-3 glutaminase was successfully over-expressed in the GRAS (Generally Recognized as Safe) Bacillus subtilis strain 168 by integration of the Mglu gene in the 16S rDNA locus. This was done in order to screen a strain
Xian Zhang +7 more
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Understanding gut-liver axis nitrogen metabolism in Fatty Liver Disease
Frontiers in Endocrinology, 2022 The homeostasis of the most important nitrogen-containing intermediates, ammonia and glutamine, is a tightly regulated process in which the gut-liver axis plays a central role.
Teresa C. Delgado +6 more
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Scientific Reports, 2021 l-Asparaginase is a therapeutically and industrially-competent enzyme, acting predominantly as an anti-neoplastic and anti-cancerous agent. The existing formulations of prokaryotic l-asparaginase are often toxic and contain l-glutaminase and urease ...
Meghna Chakraborty, Srividya Shivakumar
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GMP Synthetase: Allostery, Structure, and Function
Biomolecules, 2023 Glutamine amidotransferases (GATs) catalyze the hydrolysis of glutamine and transfer the generated ammonia to diverse metabolites. The two catalytic activities, glutaminolysis and the subsequent amination of the acceptor substrate, happen in two distinct
Lionel Ballut +4 more
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