Results 11 to 20 of about 20,010 (192)
Frontiers in Oncology, 2020 Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis, tumor growth, and the production of antioxidants through glutaminolysis in ...
Zhefang Wang +9 more
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Metformin inhibits glutaminase activity and protects against hepatic encephalopathy. [PDF]
PLoS ONE, 2012 AIM: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients.
Javier Ampuero +10 more
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TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase
Journal of Neuroinflammation, 2017 Background Extracellular vesicles (EVs) are membrane-contained vesicles shed from cells. EVs contain proteins, lipids, and nucleotides, all of which play important roles in intercellular communication.
Kaizhe Wang +6 more
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Production, characterization, and antitumor efficiency of l-glutaminase from halophilic bacteria
Bulletin of the National Research Centre, 2022 Background Halophiles are an excellent source of enzymes that are not only salt stable, but also can withstand and carry out reaction efficiently under extreme conditions.
Eman Zakaria Gomaa
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Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes. [PDF]
, 2020 Background: Metabolic reprogramming of tumours is a hallmark of cancer. Among the changes in the metabolic network of cancer cells, glutaminolysis is a key reaction altered in neoplasms. Glutaminase proteins control the first step in glutamine metabolism
Mates-Sánchez, José Manuel +5 more
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THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy. [PDF]
PLoS ONE, 2014 Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity the main source for ammonia.
M Mar Díaz-Herrero +8 more
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Application Prospect of Protein-Glutaminase in the Development of Plant-Based Protein Foods
Foods, 2022 Plant-based protein foods as suitable alternative protein sources have recently received increased global interest. The scientific community is exploring effective modification approaches to enhance the functionality of plant-based proteins for expanded ...
Xiao Liu +5 more
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Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma
Clinical and Translational Medicine, 2022 Background Glutaminolysis is a critical metabolic process that promotes cancer cell proliferation, including hepatocellular carcinoma (HCC). Delineating the molecular control of glutaminolysis could identify novel targets to ameliorate this oncogenic ...
Taotao Zhang +14 more
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Research Progress in Improving Efficacy of Radiotherapy by Targeting Glutamine Metabolism
Zhongliu Fangzhi Yanjiu, 2023 Radiotherapy is an important treatment method for malignant tumors. Radiation resistance is the main obstacle to the therapeutic effect of radiotherapy. Cellular metabolic reprogramming is one of the main features of cancer, and it may have an important ...
QIAO Wanjia, DONG Na, LIU Xiaojun
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, 2019 After metabolic reprogramming, many cancer cells become glutamine addicted, that is, they depend on a high consumption of this amino acid for their survival and proliferation.
Campos-Sandoval, José A. +2 more
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