Interferon-α regulates glutaminase 1 promoter through STAT1 phosphorylation: relevance to HIV-1 associated neurocognitive disorders. [PDF]
PLoS ONE, 2012 HIV-1 associated neurocognitive disorders (HAND) develop during progressive HIV-1 infection and affect up to 50% of infected individuals. Activated microglia and macrophages are critical cell populations that are involved in the pathogenesis of HAND ...
Lixia Zhao +7 more
doaj +1 more source
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2019 After metabolic reprogramming, many cancer cells become glutamine addicted, that is, they depend on a high consumption of this amino acid for their survival and proliferation. Glutaminase catalyzes the stoichiometric conversion of L-glutamine to L-glutamate and ammonium ions, the first step of glutaminolysis.
Campos-Sandoval, José A. +2 more
openaire +2 more sources
Frontiers in Oncology, 2020 Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis, tumor growth, and the production of antioxidants through glutaminolysis in ...
Zhefang Wang +9 more
doaj +1 more source
Metformin inhibits glutaminase activity and protects against hepatic encephalopathy. [PDF]
PLoS ONE, 2012 AIM: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients.
Javier Ampuero +10 more
doaj +1 more source
TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase
Journal of Neuroinflammation, 2017 Background Extracellular vesicles (EVs) are membrane-contained vesicles shed from cells. EVs contain proteins, lipids, and nucleotides, all of which play important roles in intercellular communication.
Kaizhe Wang +6 more
doaj +1 more source
Production, characterization, and antitumor efficiency of l-glutaminase from halophilic bacteria
Bulletin of the National Research Centre, 2022 Background Halophiles are an excellent source of enzymes that are not only salt stable, but also can withstand and carry out reaction efficiently under extreme conditions.
Eman Zakaria Gomaa
doaj +1 more source
Application Prospect of Protein-Glutaminase in the Development of Plant-Based Protein Foods
Foods, 2022 Plant-based protein foods as suitable alternative protein sources have recently received increased global interest. The scientific community is exploring effective modification approaches to enhance the functionality of plant-based proteins for expanded ...
Xiao Liu +5 more
doaj +1 more source
Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster? [PDF]
, 2019 Distinct from normal differentiated tissues, cancer cells reprogram nutrient uptake and utilization to accommodate their elevated demands for biosynthesis and energy production.
Jiang, Jie +2 more
core +1 more source
Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma
Clinical and Translational Medicine, 2022 Background Glutaminolysis is a critical metabolic process that promotes cancer cell proliferation, including hepatocellular carcinoma (HCC). Delineating the molecular control of glutaminolysis could identify novel targets to ameliorate this oncogenic ...
Taotao Zhang +14 more
doaj +1 more source
Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]
, 2019 York University ...
Bhattacharya, Debasmita, Scimè, Anthony
core +1 more source