Metformin inhibits glutaminase activity and protects against hepatic encephalopathy. [PDF]
PLoS ONE, 2012 AIM: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients.
Javier Ampuero +10 more
doaj +4 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2019 After metabolic reprogramming, many cancer cells become glutamine addicted, that is, they depend on a high consumption of this amino acid for their survival and proliferation. Glutaminase catalyzes the stoichiometric conversion of L-glutamine to L-glutamate and ammonium ions, the first step of glutaminolysis.
Campos-Sandoval, José A. +2 more
openaire +4 more sources
MicroRNA-153 regulates glutamine metabolism in glioblastoma through targeting glutaminase
Tumor Biology, 2017 Glioblastoma is the most aggressive manifestation of malignant gliomas and considered to be among the deadliest forms of human cancers. MicroRNAs are found to tightly regulate diverse biological processes and considered to play important roles in cancer ...
Zhenyang Liu +5 more
doaj +2 more sources
The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy [PDF]
Nature Communications, 2016 Cancer cells have previously been shown to be addicted to glutamine and glutaminase enzyme activity. Here, the authors show that overexpression of the JUN proto-oncogene in breast cancer cells regulates glutaminaseexpression and is sufficient to confer ...
Michael J. Lukey +4 more
doaj +2 more sources
High-Throughput Screening Reveals New Glutaminase Inhibitor Molecules
, 2021 The glutaminase (GLS) enzyme hydrolyzes glutamine into glutamate, an important anaplerotic source for the tricarboxylic acid cycle in rapidly growing cancer cells under the Warburg effect.
Cyro von Zuben de Valega Negrao (11777403) +17 more
core +2 more sources
Targeting Glutaminase Isoforms GLS and GLS2 in Luminal Breast Cancer. [PDF]
Int J Mol SciUpregulation of glutaminase enzymatic activity promotes tumour cell proliferation. Its overexpression correlates with poor disease outcome in patients, including those with breast cancer.
Masisi BK +5 more
europepmc +2 more sources
TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase
Journal of Neuroinflammation, 2017 Background Extracellular vesicles (EVs) are membrane-contained vesicles shed from cells. EVs contain proteins, lipids, and nucleotides, all of which play important roles in intercellular communication.
Kaizhe Wang +6 more
doaj +1 more source
Production, characterization, and antitumor efficiency of l-glutaminase from halophilic bacteria
Bulletin of the National Research Centre, 2022 Background Halophiles are an excellent source of enzymes that are not only salt stable, but also can withstand and carry out reaction efficiently under extreme conditions.
Eman Zakaria Gomaa
doaj +1 more source
THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy. [PDF]
PLoS ONE, 2014 Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity the main source for ammonia.
M Mar Díaz-Herrero +8 more
doaj +1 more source
Application Prospect of Protein-Glutaminase in the Development of Plant-Based Protein Foods
Foods, 2022 Plant-based protein foods as suitable alternative protein sources have recently received increased global interest. The scientific community is exploring effective modification approaches to enhance the functionality of plant-based proteins for expanded ...
Xiao Liu +5 more
doaj +1 more source