Results 41 to 50 of about 24,633 (278)
, 2020 L-asparaginase (ASNase) is an essential drug in the treatment of acute lymphoblastic leukemia (ALL). Commercial bacterial ASNases increase patient survival, but the consequent immunological reactions remain a challenge.
Rafael Bertelli Ferraro (9370271) +8 more
core +1 more source
The Role of Glutamine and Glutaminase in Pulmonary Hypertension
Frontiers in Cardiovascular Medicine, 2022 Pulmonary hypertension (PH) refers to a clinical and pathophysiological syndrome in which pulmonary vascular resistance and pulmonary arterial pressure are increased due to structural or functional changes in pulmonary vasculature caused by a variety of ...
Shang Wang +10 more
semanticscholar +1 more source
Expression of Gls and Gls2 glutaminase isoforms in astrocytes [PDF]
, 2015 The expression of glutaminase in glial cells has been a controversial issue and matter of debate for many years. Actually, glutaminase is essentially considered as a neuronal marker in brain.
Mates-Sánchez, José Manuel +43 more
core +1 more source
Molecules, 2019 In this study, the Micrococcus luteus K-3 glutaminase was successfully over-expressed in the GRAS (Generally Recognized as Safe) Bacillus subtilis strain 168 by integration of the Mglu gene in the 16S rDNA locus. This was done in order to screen a strain
Xian Zhang +7 more
doaj +1 more source
SNAP25 Inhibits Glioma Progression by Regulating Synapse Plasticity via GLS-Mediated Glutaminolysis
Frontiers in Oncology, 2021 BackgroundNeuronal activity regulated by synaptic communication exerts an important role in tumorigenesis and progression in brain tumors. Genes for soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) annotated with the ...
Qiongzhen Huang +7 more
doaj +1 more source
Targeting glutaminase and mTOR
Oncotarget, 2015 Comprehensive genomic and proteomic analyses demonstrate that there is nearly universal activation of the PI3K pathway in glioblastoma (GBM) patients [1]. Persistent PI3K signaling promotes GBM formation and tumor progression in genetic mouse models, establishing PI3K and its effecter mTOR as compelling molecular targets.
Kazuhiro, Tanaka +2 more
openaire +2 more sources
Future Drug Discovery, 2022 Metabolic reprogramming is a major hallmark of malignant transformation in cancer, and part of the so-called Warburg effect, in which the upregulation of glutamine catabolism plays a major role.
T. Nguyen, William P. Katt, R. Cerione
semanticscholar +1 more source
Cocaine modulates both glutaminase gene expression and glutaminase activity in the brain of cocaine-sensitized mice [PDF]
, 2011 Glutaminase is considered the main Glutamate (Glu) producing enzyme. Two isoforms, liver (LGA) and kidney (KGA) type glutaminases have been identified in neurons.
José Ángel Campos-Sandoval +15 more
core +1 more source
ON THE PRESENCE OF GLUTAMINASE IN MUSCLE [PDF]
Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1969 The glutaminase activity of rat cardiac and skeletal muscle has been investigated, and compared with that of rat kidney. Vmax per g. of protein was 42 µmole/hr for heart muscle homogenates and 478 µmole/hr for kidney homogenates. Glutaminase activity was not detectable in about 50 per cent of the skeletal muscle homogenates; in the other 50 per cent ...
openaire +2 more sources
Frontiers in Immunology, 2023 ObjectivesThe mechanism of Brucella infection regulating macrophage phenotype has not been completely elucidated until now. This study aimed to determine the mechanism of Brucella abortus in the modulation of macrophage phenotype using RAW264.7 cells as ...
Tianyi Zhao +15 more
doaj +1 more source