Results 41 to 50 of about 19,538 (222)

Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells

, 2017
Glutaminolysis that catabolizes glutamine to glutamate plays a critical role in cancer progression. Glutaminase 2 (GLS2) has been reported as a tumor suppressor.
Kuo, Tsang-Chih;Chen, Chi-Kuan;Hua, Kuo-Tai;Yu, Pei;Lee, Wei-Jiunn;Chen, Min-Wei;Jeng, Yung-Ming;Chien, Ming-Hsien;Kuo, Kuang-Tai;Hsiao, Michael;Kuo, Min-Liang, 華國泰;鄭永銘   +1 more
core   +1 more source

Optimization Of Culture Conditions For Maximizing L-glutaminase Production From The Marine Fungus Aspergillus flavus [PDF]

Delta Journal of Science
Marine fungi have the capacity to extreme environments and   live in a highly competitive ecological position make them suppliers of novel metabolites as L-glutaminase   which is medically useful in the pharmaceutical industry, as an antioxidant and ...
Omyma Awadalla, Maha Azab, Hagar Hussien, Abd El-Raheem El-Shanshoury   +3 more
doaj   +1 more source

Erastin-like anti-Warburg compounds X1 and X4 are GLS2-selective covalent glutaminase inhibitors [PDF]

The Warburg effect is a metabolic alteration in cancer cells characterized by aerobic glycolysis and lactate production. A recent phenotypic screen for compounds that reverse Warburg metabolism identified two compounds, X1 and X4, that restore the ...
Morgan, Miele, Ranjini, Iyengar, Sainabou, Jallow, Scott, Ulrich, Clea, Crane, Noah, Strathmann   +5 more
core   +1 more source

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation [PDF]

, 2010
SummaryRho GTPases impact a number of activities important for oncogenesis. We describe a small molecule inhibitor that blocks oncogenic transformation induced by various Rho GTPases in fibroblasts, and the growth of human breast cancer and B lymphoma ...
Chi V. Dang, Ambrosio, Andre L.B., Sandra M.G. Dias, Erickson, Jon W., Gao, Ping, Dinavahi, Ramani, Wang, Jian-Bin, Jian-Bin Wang, Fuji, Reina, Wilson, Kristin F., Ramachandran, Sekar, Dias, Sandra M.G., Kristin F. Wilson, Sekar Ramachandran, Dang, Chi V., Ramani Dinavahi, Cerione, Richard A., Richard A. Cerione, Jon W. Erickson, Ping Gao, Reina Fuji, Andre L.B. Ambrosio   +21 more
core   +1 more source

Streamlined Efficient Synthesis and Antioxidant Activity of γ-[Glutamyl]_(n≥1)-tryptophan Peptides by Glutaminase from Bacillus amyloliquefaciens

Molecules, 2023
As a group of naturally occurring peptides in various foods, γ-glutamyl peptides possess a unique Kokumi taste and health benefits. However, few studies have focused on the functionality of γ-glutamyl peptides. In this study, the γ-[glutamyl] (n=1, 2, 3)-
Wenjiang He, Xiaoling Huang, Abulimiti Kelimu, Wenzhi Li, Chun Cui   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Anticancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) capped silver and zinc oxide nanoparticles and its molecular characterization

Bioresources and Bioprocessing
The current investigation reports anti-cancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) and L-Glutaminase capped nanoparticles.
Zabin K. Bagewadi, Gouri H. Illanad, T. M. Yunus Khan, Shaik Mohamed Shamsudeen, Sikandar I. Mulla   +4 more
doaj   +1 more source

Therapeutic Potential of Glutamine Pathway in Lung Cancer

Frontiers in Oncology, 2022
Cancer cells tend to obtain the substances needed for their development depending on altering metabolic characteristics. Among the reorganized metabolic pathways, Glutamine pathway, reprogrammed to be involved in the physiological process including ...
Enyu Tang, Siyang Liu, Zhiming Zhang, Rixin Zhang, Dejing Huang, Tong Gao, Tianze Zhang, Guangquan Xu   +7 more
doaj   +1 more source

Glutamine and Glutaminase in Blood

Clinical Chemistry, 1956
Abstract A convenient and accurate procedure for the determination of glutaminase activity and glutamine in blood has been described. Kidney homogenate from rats made acidotic by feeding NH4CL was used as a glutaminase source and the Conway microdiffusion method was used to determine ammonia.
J, BRUTON, F L, IBER
openaire   +2 more sources

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source