Results 41 to 50 of about 15,841 (191)

Glutamate Metabolism in Brain Structures in Experimental Hemorrhagic Shock

Общая реаниматология, 2017
Purpose. To study glutamate metabolism characteristics in phylogenetically different parts of the mammalian brain in experimentally induced hemorrhagic shock (HS) in cats.Material and methods. Experiments were performed on 76 cats.
V. N. Jakovlev, P. N. Savilov, Y. V. Bulgakova   +2 more
doaj   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Brucella abortus modulates macrophage polarization and inflammatory response by targeting glutaminases through the NF-κB signaling pathway

Frontiers in Immunology, 2023
ObjectivesThe mechanism of Brucella infection regulating macrophage phenotype has not been completely elucidated until now. This study aimed to determine the mechanism of Brucella abortus in the modulation of macrophage phenotype using RAW264.7 cells as ...
Tianyi Zhao, Zedan Zhang, Yitao Li, Zhihua Sun, Liangbo Liu, Xingmei Deng, Jia Guo, Dexin Zhu, Shuzhu Cao, Yingjin Chai, Usevich Vera Nikolaevna, Usevich Vera Nikolaevna, Suleimenov Maratbek, Suleimenov Maratbek, Zhen Wang, Hui Zhang   +15 more
doaj   +1 more source

Root Order Dependent Changes in Fine‐Root Substrate and Soil Environment Regulate Soil Organic Nitrogen Fractions Under Acid Rain and Nitrogen Deposition

Land Degradation &Development, EarlyView.
ABSTRACT Acid rain and nitrogen deposition are important environmental stressors affecting soil nitrogen cycling in subtropical forests, whereas fine‐root decomposition represents a major pathway for soil organic nitrogen (SON) input and transformation.
Xiongfei Zhang, Xingyu Zhang, Jinchi Zhang, Jialei Ren, Chong Li, Hui Nie, Jingyi Zeng, Xuanran Yu, Jie Lin, Tingyu Sun, Xin Liu   +10 more
wiley   +1 more source

The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

Nature Communications, 2016
Cancer cells have previously been shown to be addicted to glutamine and glutaminase enzyme activity. Here, the authors show that overexpression of the JUN proto-oncogene in breast cancer cells regulates glutaminaseexpression and is sufficient to confer ...
Michael J. Lukey, Kai Su Greene, Jon W. Erickson, Kristin F. Wilson, Richard A. Cerione   +4 more
doaj   +1 more source

The Glutaminase-Dependent System Confers Extreme Acid Resistance to New Species and Atypical Strains of Brucella

Frontiers in Microbiology, 2017
Neutralophilic bacteria have developed specific mechanisms to cope with the acid stress encountered in environments such as soil, fermented foods, and host compartments. In Escherichia coli, the glutamate decarboxylase (Gad)-dependent system is extremely
Luca Freddi, Maria A. Damiano, Laurent Chaloin, Eugenia Pennacchietti, Sascha Al Dahouk, Stephan Köhler, Daniela De Biase, Alessandra Occhialini   +7 more
doaj   +1 more source

Activation of hepatic glutaminase by spermine [PDF]

Biochemical Journal, 1995
Glutaminase activity in intact mitochondria from rat liver is activated by spermine, as indicated both by increased glutamate production from glutamine and by increased respiration with glutamine as sole substrate. Glutaminase activity assayed in membranes from frozen-thawed mitochondria, is activated by spermine about 6-fold at physiological ...
Z, Kovacevic, S H, Day, V, Collett, J T, Brosnan, M E, Brosnan   +4 more
openaire   +2 more sources

Effect of Salinity Stress on Gut–Brain–Gonad Axis in the Red‐Eared Slider (Trachemys scripta elegans)

Integrative Zoology, EarlyView.
The increase in salinity leads to changes in the gut microbiota and metabolites of Trachemys scripta elegans, affecting the synthesis and secretion of neurotransmitters or precursors, which can inhibit the secretion of reproductive hormones and affect the self‐renewal and differentiation process of spermatogonial stem cells.
Qiongyu Zhang, Na Li, Xue Tang, Hanru Chen, Meiling Hong, Li Ding   +5 more
wiley   +1 more source

MicroRNA-153 regulates glutamine metabolism in glioblastoma through targeting glutaminase

Tumor Biology, 2017
Glioblastoma is the most aggressive manifestation of malignant gliomas and considered to be among the deadliest forms of human cancers. MicroRNAs are found to tightly regulate diverse biological processes and considered to play important roles in cancer ...
Zhenyang Liu, Junyu Wang, Yunjun Li, Juan Fan, Lihua Chen, Ruxiang Xu   +5 more
doaj   +1 more source

The Effect of Fertilizers in Amidohydrolases enzymes in sunflower (Helianthus annuus) Rhizoshper [PDF]

Al-Qadisiyah Journal For Agriculture Sciences, 2016
To study the enzymes activity for (Amidase , Urease , L-Asparaginase , L-Glutaminase and L-Aspartase) in sunflower plant rhizosphere in two different textures and the effect of the fertilizers kinds (mineral fertilizer , organic fertilizer and ...
Luma .S.J. Al-Taweel
doaj   +1 more source