Results 51 to 60 of about 24,633 (278)

Genetic pharmacotherapy as an early CNS drug development strategy: testing glutaminase inhibition for schizophrenia treatment in adult mice

Frontiers in Systems Neuroscience, 2016
Genetic pharmacotherapy is an early drug development strategy for the identification of novel CNS targets in mouse models prior to the development of specific ligands.
Susana eMingote, Susana eMingote, Justine eMasson, Justine eMasson, Celia eGellman, Gretchen Miller Thomsen, Gretchen Miller Thomsen, Chyuan-Sheng eLin, Robert J. Merker, Inna eGaisler-Salomon, Inna eGaisler-Salomon, Yvonne eWang, Rachel eErnst, Rene eHen, Rene eHen, Stephen eRayport, Stephen eRayport   +16 more
doaj   +1 more source

The Effect of Fertilizers in Amidohydrolases enzymes in sunflower (Helianthus annuus) Rhizoshper [PDF]

Al-Qadisiyah Journal For Agriculture Sciences, 2016
To study the enzymes activity for (Amidase , Urease , L-Asparaginase , L-Glutaminase and L-Aspartase) in sunflower plant rhizosphere in two different textures and the effect of the fertilizers kinds (mineral fertilizer , organic fertilizer and ...
Luma .S.J. Al-Taweel
doaj   +1 more source

Enhancing the usability of pea protein isolate in food applications through modifying its structural and sensory properties via deamidation by glutaminase.

Journal of Agricultural and Food Chemistry, 2020
This study aimed to demonstrate the feasibility of improving the properties of pea protein isolate (PPI) related to food applications via deamidation with glutaminase.
Luyi Fang, H. Xiang, D. Sun-Waterhouse, Chun Cui, Junjie Lin   +4 more
semanticscholar   +1 more source

5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA-Mutant Colorectal Cancers

Cancer Research, 2020
Preclinical and clinical trial data suggest that the combination of CB-839 with capecitabine could serve as an effective treatment for PIK3CA-mutant colorectal cancers. PIK3CA encodes the p110α catalytic subunit of PI3K and is frequently mutated in human
Yiqing Zhao, Xiujing Feng, Yicheng Chen, J. Selfridge, Shashank Gorityala, Zhanwen Du, Janet Wang, Yujun Hao, G. Cioffi, R. A. Conlon, J. Barnholtz-Sloan, J. Saltzman, S. Krishnamurthi, S. Vinayak, M. Veigl, Yan Xu, D. Bajor, S. Markowitz, Neal J. Meropol, J. Eads, Zhenghe Wang   +20 more
semanticscholar   +1 more source

Enhanced salt-tolerance of Bacillus subtilis glutaminase by fusing self-assembling amphipathic peptides at its N-terminus

Frontiers in Bioengineering and Biotechnology, 2022
Glutaminase (EC 3.5.1.2) can catalyze the deamidation of glutamine, which has been used to improve umami taste in oriental fermented foods. However, a high salt concentration is still a fundamental challenge for glutaminase application, especially in soy
Song Liu, Song Liu, Song Liu, Shengqi Rao, Xiao Chen, Xiao Chen, Jianghua Li, Jianghua Li   +7 more
doaj   +1 more source

Glutamine and Glutaminase in Blood

Clinical Chemistry, 1956
Abstract A convenient and accurate procedure for the determination of glutaminase activity and glutamine in blood has been described. Kidney homogenate from rats made acidotic by feeding NH4CL was used as a glutaminase source and the Conway microdiffusion method was used to determine ammonia.
J, BRUTON, F L, IBER
openaire   +2 more sources

Activation of hepatic glutaminase by spermine [PDF]

Biochemical Journal, 1995
Glutaminase activity in intact mitochondria from rat liver is activated by spermine, as indicated both by increased glutamate production from glutamine and by increased respiration with glutamine as sole substrate. Glutaminase activity assayed in membranes from frozen-thawed mitochondria, is activated by spermine about 6-fold at physiological ...
Z, Kovacevic, S H, Day, V, Collett, J T, Brosnan, M E, Brosnan   +4 more
openaire   +2 more sources

L-Glutaminase Synthesis by Marine Halomonas meridiana Isolated from the Red Sea and Its Efficiency against Colorectal Cancer Cell Lines

Molecules, 2021
L-glutaminase is an important anticancer agent that is used extensively worldwide by depriving cancer cells of L-glutamine. The marine bacterium, Halomonas meridian was isolated from the Red Sea and selected as the more active L-glutaminase-producing ...
Y. Mostafa, S. Alamri, M. Alfaifi, S. Alrumman, S. E. Elbehairi, Tarek H. Taha, M. Hashem   +6 more
semanticscholar   +1 more source

Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization

Cell Death and Disease, 2019
Cancer cells re-program their metabolic machinery to meet the requirements of malignant transformation and progression. Glutaminase 1 (GLS1) was traditionally known as a mitochondrial enzyme that hydrolyzes glutamine into glutamate and fuels rapid ...
Lisha Xiang, J. Mou, B. Shao, Yuquan Wei, Houjie Liang, Naoharu Takano, G. Semenza, Ganfeng Xie   +7 more
semanticscholar   +1 more source

Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells

, 2017
Glutaminolysis that catabolizes glutamine to glutamate plays a critical role in cancer progression. Glutaminase 2 (GLS2) has been reported as a tumor suppressor.
Kuo, Tsang-Chih;Chen, Chi-Kuan;Hua, Kuo-Tai;Yu, Pei;Lee, Wei-Jiunn;Chen, Min-Wei;Jeng, Yung-Ming;Chien, Ming-Hsien;Kuo, Kuang-Tai;Hsiao, Michael;Kuo, Min-Liang, 華國泰;鄭永銘   +1 more
core   +1 more source