Results 51 to 60 of about 20,010 (192)

Glutamate Metabolism in Brain Structures in Experimental Hemorrhagic Shock

Общая реаниматология, 2017
Purpose. To study glutamate metabolism characteristics in phylogenetically different parts of the mammalian brain in experimentally induced hemorrhagic shock (HS) in cats.Material and methods. Experiments were performed on 76 cats.
V. N. Jakovlev, P. N. Savilov, Y. V. Bulgakova   +2 more
doaj   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Brucella abortus modulates macrophage polarization and inflammatory response by targeting glutaminases through the NF-κB signaling pathway

Frontiers in Immunology, 2023
ObjectivesThe mechanism of Brucella infection regulating macrophage phenotype has not been completely elucidated until now. This study aimed to determine the mechanism of Brucella abortus in the modulation of macrophage phenotype using RAW264.7 cells as ...
Tianyi Zhao, Zedan Zhang, Yitao Li, Zhihua Sun, Liangbo Liu, Xingmei Deng, Jia Guo, Dexin Zhu, Shuzhu Cao, Yingjin Chai, Usevich Vera Nikolaevna, Usevich Vera Nikolaevna, Suleimenov Maratbek, Suleimenov Maratbek, Zhen Wang, Hui Zhang   +15 more
doaj   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Glutaminase isoenzymes in the metabolic 1 therapy of cancer [PDF]

, 2018
Mensaje de la editorial Elsevier: Dear Dr. José A. Campos-Sandoval, I have attached the accepted version of your manuscript for your reference. Kindly check and let me know if you need any further assistance.
Mates-Sánchez, José Manuel, Márquez-Gómez, Javier, Campos-Sandoval, José Ángel   +2 more
core   +1 more source

The Glutaminase-Dependent System Confers Extreme Acid Resistance to New Species and Atypical Strains of Brucella

Frontiers in Microbiology, 2017
Neutralophilic bacteria have developed specific mechanisms to cope with the acid stress encountered in environments such as soil, fermented foods, and host compartments. In Escherichia coli, the glutamate decarboxylase (Gad)-dependent system is extremely
Luca Freddi, Maria A. Damiano, Laurent Chaloin, Eugenia Pennacchietti, Sascha Al Dahouk, Stephan Köhler, Daniela De Biase, Alessandra Occhialini   +7 more
doaj   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Biochemical and biological evaluation of L-glutaminase from Aspergillus tamarii AUMC 10198 via solid-state fermentation

Microbial Cell Factories
Introduction Fungal L-glutaminase has recently attracted growing interest due to its potential applications in medical therapy and biotechnology. This study aimed to develop a cost-effective bioprocess for L-glutaminase production using agricultural by ...
Ghada A. Youssef, Maii S. Zaid, Amany S. Youssef, Samy El-Aassar   +3 more
doaj   +1 more source

The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

Nature Communications, 2016
Cancer cells have previously been shown to be addicted to glutamine and glutaminase enzyme activity. Here, the authors show that overexpression of the JUN proto-oncogene in breast cancer cells regulates glutaminaseexpression and is sufficient to confer ...
Michael J. Lukey, Kai Su Greene, Jon W. Erickson, Kristin F. Wilson, Richard A. Cerione   +4 more
doaj   +1 more source

The Effect of Fertilizers in Amidohydrolases enzymes in sunflower (Helianthus annuus) Rhizoshper [PDF]

Al-Qadisiyah Journal For Agriculture Sciences, 2016
To study the enzymes activity for (Amidase , Urease , L-Asparaginase , L-Glutaminase and L-Aspartase) in sunflower plant rhizosphere in two different textures and the effect of the fertilizers kinds (mineral fertilizer , organic fertilizer and ...
Luma .S.J. Al-Taweel
doaj   +1 more source