Biomolecules, 2021 A better understanding of the metabolic constraints of a tumor may lead to more effective anticancer treatments. Evidence has emerged in recent years shedding light on a crucial aspartate dependency of many tumor types.
Iiro Taneli Helenius +2 more
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Cocaine modulates both glutaminase gene expression and glutaminase activity in the brain of cocaine-sensitized mice [PDF]
, 2011 Glutaminase is considered the main Glutamate (Glu) producing enzyme. Two isoforms, liver (LGA) and kidney (KGA) type glutaminases have been identified in neurons.
José Ángel Campos-Sandoval +15 more
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Antioxidants, 2023 Cancer cells show increased glutamine consumption. The glutaminase (GLS) enzyme controls a limiting step in glutamine catabolism. Breast tumors, especially the triple-negative subtype, have a high expression of GLS. Our recent study demonstrated that GLS
Federica Barreca +7 more
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ROLE OF CARBON SOURCE FOR THE PRODUCTION OF L-GLUTAMINASE FROM ASPERGILLUS ORYZAE [PDF]
, 2014 Microbial glutaminases are more stable than plant and animal counterparts. In addition to it, they have also been detected in mammalian tissues where they are the major enzymes responsible for catabolic breakdown of glutamine. This study were taken up to
Siddalingeshwara, K G +3 more
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Frontiers in Oncology, 2022 Pyruvate carboxylase (PC) is an important anaplerotic enzyme that replenishes the tricarboxylic acid cycle (TCA) intermediates. It prevents the collapse of the TCA cycle upon its intermediates are removed during high anabolic demand.
Jarunya Ngamkham +4 more
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Identification of Inhibitors of Phosphate-activated Glutaminase for the Pharmacotherapy of Schizophrenia [PDF]
, 2020 In the brain, phosphate-activated glutaminase catalyzes the recycling of glutamine back to glutamate for excitatory neurotransmission. In mice, genetic knockdown of phosphate-activated glutaminase has been shown to confer resilience to schizophrenia-like
Mihali, Andra +5 more
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Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells
, 2017 Glutaminolysis that catabolizes glutamine to glutamate plays a critical role in cancer progression. Glutaminase 2 (GLS2) has been reported as a tumor suppressor.
Kuo, Tsang-Chih;Chen, Chi-Kuan;Hua, Kuo-Tai;Yu, Pei;Lee, Wei-Jiunn;Chen, Min-Wei;Jeng, Yung-Ming;Chien, Ming-Hsien;Kuo, Kuang-Tai;Hsiao, Michael;Kuo, Min-Liang +1 more
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Erastin-like anti-Warburg compounds X1 and X4 are GLS2-selective covalent glutaminase inhibitors [PDF]
The Warburg effect is a metabolic alteration in cancer cells characterized by aerobic glycolysis and lactate production. A recent phenotypic screen for compounds that reverse Warburg metabolism identified two compounds, X1 and X4, that restore the ...
Morgan, Miele +5 more
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Physical properties of protein-glutaminase (PG)-treated and control soy protein isolate (SPI).
, 2023 Physical properties of protein-glutaminase (PG)-treated and control soy protein isolate (SPI).
Kiyota Sakai (819111) +2 more
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Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells [PDF]
, 2014 [[abstract]]Glutaminase, which converts glutamine to glutamate, is involved in Warburg effect in cancer cells. Two human glutaminase genes have been identified, GLS (GLS1) and GLS2. Two alternative transcripts arise from each glutaminase gene: first, the
Lee, YZ;Yang, CW;Chang, HY;Hsu, HY;Chen, IS;Chang, HS;Lee, CH;Lee, JC;Kumar, CR;Qiu, YQ;Chao, YS;Lee, SJ
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