Results 31 to 40 of about 24,633 (278)

TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase

Journal of Neuroinflammation, 2017
Background Extracellular vesicles (EVs) are membrane-contained vesicles shed from cells. EVs contain proteins, lipids, and nucleotides, all of which play important roles in intercellular communication.
Kaizhe Wang, Ling Ye, Hongfang Lu, Huili Chen, Yanyan Zhang, Yunlong Huang, Jialin C. Zheng   +6 more
doaj   +1 more source

THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy. [PDF]

PLoS ONE, 2014
Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity the main source for ammonia.
M Mar Díaz-Herrero, José A del Campo, Pilar Carbonero-Aguilar, José M Vega-Pérez, Fernando Iglesias-Guerra, Ignacio Periñán, Francisco J Miñano, Juan Bautista, Manuel Romero-Gómez   +8 more
doaj   +1 more source

KEAP1/NFE2L2 mutations predict lung cancer radiation resistance that can be targeted by glutaminase inhibition.

Cancer Discovery, 2020
Tumor genotyping is not routinely performed in localized non-small cell lung cancer (NSCLC) due to lack of associations of mutations with outcome. Here, we analyze 232 consecutive patients with localized NSCLC and demonstrate that KEAP1 and NFE2L2 ...
M. Binkley, Young-Jun Jeon, Monica C. Nesselbush, E. Moding, B. Nabet, Diego Almanza, C. Kunder, H. Stehr, C. Yoo, Siyeon Rhee, M. Xiang, J. Chabon, Emily G. Hamilton, D. Kurtz, Linda Gojenola, S. G. Owen, R. Ko, J. Shin, P. Maxim, N. Lui, L. Backhus, M. Berry, J. Shrager, K. Ramchandran, S. Padda, M. Das, J. Neal, H. Wakelee, Ash A. Alizadeh, B. Loo, M. Diehn   +30 more
semanticscholar   +1 more source

Targeting hepatic Glutaminase 1 ameliorates Non-Alcoholic Steatohepatitis by restoring Very-Low Density Lipoproteins triglyceride assembly

Cell Metabolism, 2020
Summary Non-alcoholic steatohepatitis (NASH) is characterized by the accumulation of hepatic fat in an inflammatory/fibrotic background. Herein, we show that the hepatic high-activity glutaminase 1 isoform (GLS1) is overexpressed in NASH.
J. Simón, Maitane Núñez-García, Pablo Fernández-Tussy, Lucía Barbier-Torres, David Fernández‐Ramos, Beatriz Gómez-Santos, Xabier Buqué, F. Lopitz‐Otsoa, Naroa Goikoetxea‐Usandizaga, Marina Serrano‐Maciá, Rubén Rodríguez-Agudo, Maider Bizkarguenaga, Imanol Zubiete-Franco, V. Juan, D. Cabrera, C. Alonso, P. Iruzubieta, M. Romero‐Gomez, S. van Liempd, Azucena Castro, R. Nogueiras, M. Varela-Rey, J. Falcón-Pérez, E. Villa, J. Crespo, Shelly C. Lu, J. Mato, P. Aspichueta, T. C. Delgado, M. Martínez‐Chantar   +29 more
semanticscholar   +1 more source

Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes. [PDF]

, 2020
Background: Metabolic reprogramming of tumours is a hallmark of cancer. Among the changes in the metabolic network of cancer cells, glutaminolysis is a key reaction altered in neoplasms. Glutaminase proteins control the first step in glutamine metabolism
Mates-Sánchez, José Manuel, De los Santos-Jiménez, Juan, Márquez-Gómez, Javier, Segura-Checa, Juan Antonio, Alonso-Carrión, Francisco José, Campos-Sandoval, José Ángel   +5 more
core   +1 more source

Streamlined Efficient Synthesis and Antioxidant Activity of γ-[Glutamyl]_(n≥1)-tryptophan Peptides by Glutaminase from Bacillus amyloliquefaciens

Molecules, 2023
As a group of naturally occurring peptides in various foods, γ-glutamyl peptides possess a unique Kokumi taste and health benefits. However, few studies have focused on the functionality of γ-glutamyl peptides. In this study, the γ-[glutamyl] (n=1, 2, 3)-
Wenjiang He, Xiaoling Huang, Abulimiti Kelimu, Wenzhi Li, Chun Cui   +4 more
doaj   +1 more source

Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis

International Journal on Biological Sciences, 2022
Inhibiting cancer metabolism via glutaminase (GAC) is a promising strategy to disrupt tumor progression. However, mechanism regarding GAC acetylation remains mostly unknown.
Tao Wang, Zhuo Lu, Tianyu Han, Yanan Wang, Mingxi Gan, Jian-Bin Wang   +5 more
semanticscholar   +1 more source

Therapeutic Potential of Glutamine Pathway in Lung Cancer

Frontiers in Oncology, 2022
Cancer cells tend to obtain the substances needed for their development depending on altering metabolic characteristics. Among the reorganized metabolic pathways, Glutamine pathway, reprogrammed to be involved in the physiological process including ...
Enyu Tang, Siyang Liu, Zhiming Zhang, Rixin Zhang, Dejing Huang, Tong Gao, Tianze Zhang, Guangquan Xu   +7 more
doaj   +1 more source

The glutaminase inhibitor CB-839 (Telaglenastat) enhances the anti-melanoma activity of T cell mediated immunotherapies.

Molecular Cancer Therapeutics, 2020
Immune-checkpoint inhibitors and adoptive tumor-infiltrating lymphocyte (TIL) therapies have profoundly improved the survival of patients with melanoma.
Sruthy Varghese, Snigdha Pramanik, Leila J. Williams, Hannah R Hodges, C. Hudgens, Grant M Fischer, Catherine K. Luo, Barbara G. Knighton, L. Tan, P. Lorenzi, A. Mackinnon, J. McQuade, Y. Hailemichael, J. Roszik, Weiyi Peng, Y. V. Vashisht Gopal   +15 more
semanticscholar   +1 more source

Bioinformatic profiling identifies the glutaminase to be a potential novel cuproptosis-related biomarker for glioma

Frontiers in Cell and Developmental Biology, 2022
Glioma is the most common tumour of the central nervous system, with a poor prognosis and an increasing trend of incidence in recent years; it is also beginning to affect younger age groups more.
Zhen Ouyang, Hanyi Zhang, Wenrui Lin, J. Su, Xianggui Wang   +4 more
semanticscholar   +1 more source