Results 31 to 40 of about 27,569 (215)

Brucella abortus modulates macrophage polarization and inflammatory response by targeting glutaminases through the NF-κB signaling pathway

Frontiers in Immunology, 2023
ObjectivesThe mechanism of Brucella infection regulating macrophage phenotype has not been completely elucidated until now. This study aimed to determine the mechanism of Brucella abortus in the modulation of macrophage phenotype using RAW264.7 cells as ...
Tianyi Zhao, Zedan Zhang, Yitao Li, Zhihua Sun, Liangbo Liu, Xingmei Deng, Jia Guo, Dexin Zhu, Shuzhu Cao, Yingjin Chai, Usevich Vera Nikolaevna, Usevich Vera Nikolaevna, Suleimenov Maratbek, Suleimenov Maratbek, Zhen Wang, Hui Zhang   +15 more
doaj   +1 more source

Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells [PDF]

, 2015
BRAF inhibitors can extend progression-free and overall survival in melanoma patients whose tumors harbor mutations in BRAF. However, the majority of patients eventually develop resistance to these drugs. Here we show that BRAF mutant melanoma cells that
Baenke, Franziska, Chaneton, Barbara, Dhomen, Nathalie, Galbraith, Laura, Girotti, Maria R., Gottlieb, Eyal, Hogan, Kate, Marais, Richard, Martin, Matthew, Smith, Matthew, Tang, Haoran, Van Den Broek, Niels, Viros, Amaya   +12 more
core   +1 more source

miRNAs link metabolic reprogramming to oncogenesis [PDF]

, 2013
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M, Iliopoulos, D, Polytarchou, C   +2 more
core   +1 more source

GLS2 (Glutaminase 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
Review on GLS2 (Glutaminase 2)
Campos-Sandoval, José A, Martin-Rufian, Mercedes, Marquez, Javier   +2 more
openaire   +4 more sources

Genetic pharmacotherapy as an early CNS drug development strategy: testing glutaminase inhibition for schizophrenia treatment in adult mice

Frontiers in Systems Neuroscience, 2016
Genetic pharmacotherapy is an early drug development strategy for the identification of novel CNS targets in mouse models prior to the development of specific ligands.
Susana eMingote, Susana eMingote, Justine eMasson, Justine eMasson, Celia eGellman, Gretchen Miller Thomsen, Gretchen Miller Thomsen, Chyuan-Sheng eLin, Robert J. Merker, Inna eGaisler-Salomon, Inna eGaisler-Salomon, Yvonne eWang, Rachel eErnst, Rene eHen, Rene eHen, Stephen eRayport, Stephen eRayport   +16 more
doaj   +1 more source

The Effect of Fertilizers in Amidohydrolases enzymes in sunflower (Helianthus annuus) Rhizoshper [PDF]

Al-Qadisiyah Journal For Agriculture Sciences, 2016
To study the enzymes activity for (Amidase , Urease , L-Asparaginase , L-Glutaminase and L-Aspartase) in sunflower plant rhizosphere in two different textures and the effect of the fertilizers kinds (mineral fertilizer , organic fertilizer and ...
Luma .S.J. Al-Taweel
doaj   +1 more source

Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells. [PDF]

, 2015
A network model for the determination of tumor metabolic fluxes from (13)C NMR kinetic isotopomer data has been developed and validated with perfused human DB-1 melanoma cells carrying the BRAF V600E mutation, which promotes oxidative metabolism.
Blair, Ian A, Glickson, Jerry D, Guo, Lili, Henry, Pierre-Gilles, Lee, Seung-Cheol, Leeper, Dennis B, Mancuso, Anthony, Nelson, David S, Roman, Jeffrey C, Shestov, Alexander A   +9 more
core   +2 more sources

Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology [PDF]

, 2011
Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is
Alexei Vazquez, Zoltán N. Oltvai
core   +8 more sources

SCREENING AND CHARACTERIZATION OF L-GLUTAMINASE PRODUCED BY BACTERIA ISOLATED FROM SANGIHE TALAUD SEA

Squalen, 2013
L-glutaminase (L-glutamine amidohydrolase, EC 3.5.1.2) is a very important enzyme due to its role as flavor enhancer and antileukemic agent. Salt-tolerant L-glutaminase produced by marine bacteria is favorable in food industries. This study describes the
Ekowati Chasanah, Usman Sumo Friend Tambunan, Tanti Yulianti   +2 more
doaj   +1 more source

Enhanced salt-tolerance of Bacillus subtilis glutaminase by fusing self-assembling amphipathic peptides at its N-terminus

Frontiers in Bioengineering and Biotechnology, 2022
Glutaminase (EC 3.5.1.2) can catalyze the deamidation of glutamine, which has been used to improve umami taste in oriental fermented foods. However, a high salt concentration is still a fundamental challenge for glutaminase application, especially in soy
Song Liu, Song Liu, Song Liu, Shengqi Rao, Xiao Chen, Xiao Chen, Jianghua Li, Jianghua Li   +7 more
doaj   +1 more source