Results 21 to 30 of about 20,010 (192)

Glutaminase-free L-asparaginase production by Leucosporidium muscorum isolated from Antarctic marine-sediment

, 2020
L-asparaginase (ASNase) is an essential drug in the treatment of acute lymphoblastic leukemia (ALL). Commercial bacterial ASNases increase patient survival, but the consequent immunological reactions remain a challenge.
Rafael Bertelli Ferraro (9370271), Aldo Tonso (5836421), Lara Durães Sette (9370277), Rominne Karla Barros Freire (9370265), João Henrique Picado Madalena Santos (6325574), Felipe Rebello Lourenço (4652215), Adalberto Pessoa Junior (13192876), Carlos Miguel Nóbrega Mendonça (9370268), Ignacio Sánchez Moguel (9370274)   +8 more
core   +1 more source

Optimised production of L-glutaminase: A tumour inhibitor from Aspergillus flavus cultured on agroindustrial residues [PDF]

, 2013
L-Glutaminase, an amidohydrolase enzyme has been a choice of interest in the treatment of lymphoblastic leukemia. This study investigates the production and optimization of extracellular glutaminase enzyme using several agro-industrial residues by ...
Nath, SS, Palaniswamy, M, Angayarkanni, J, Nathiya, K   +3 more
core   +1 more source

Understanding gut-liver axis nitrogen metabolism in Fatty Liver Disease

Frontiers in Endocrinology, 2022
The homeostasis of the most important nitrogen-containing intermediates, ammonia and glutamine, is a tightly regulated process in which the gut-liver axis plays a central role.
Teresa C. Delgado, Teresa C. Delgado, Javier de las Heras, Javier de las Heras, Javier de las Heras, María L. Martínez-Chantar, María L. Martínez-Chantar   +6 more
doaj   +1 more source

Improving the Production of Salt-Tolerant Glutaminase by Integrating Multiple Copies of Mglu into the Protease and 16S rDNA Genes of Bacillus subtilis 168

Molecules, 2019
In this study, the Micrococcus luteus K-3 glutaminase was successfully over-expressed in the GRAS (Generally Recognized as Safe) Bacillus subtilis strain 168 by integration of the Mglu gene in the 16S rDNA locus. This was done in order to screen a strain
Xian Zhang, Zhaoyang Xu, Song Liu, Kai Qian, Meijuan Xu, Taowei Yang, Jianzhong Xu, Zhiming Rao   +7 more
doaj   +1 more source

Brain glutaminases

Biomolecular Concepts, 2010
Glutaminase is considered as the main glutamate producer enzyme in brain. Consequently, the enzyme is essential for both glutamatergic and gabaergic transmissions.
Márquez Javier, Martín-Rufián Mercedes, Segura Juan A., Matés José M., Campos-Sandoval José A., Alonso Francisco J.   +5 more
doaj   +1 more source

GMP Synthetase: Allostery, Structure, and Function

Biomolecules, 2023
Glutamine amidotransferases (GATs) catalyze the hydrolysis of glutamine and transfer the generated ammonia to diverse metabolites. The two catalytic activities, glutaminolysis and the subsequent amination of the acceptor substrate, happen in two distinct
Lionel Ballut, Sébastien Violot, Sanjeev Kumar, Nushin Aghajari, Hemalatha Balaram   +4 more
doaj   +1 more source

Studies on Characteristic of Extracellular L–Glutaminase and Identification of L-Glutaminase Producing Bacterial Strain from Cattle Feeding Farm of Chhatrapati Sambhajinagar, Maharashtra State, India [PDF]

, 2023
L-glutaminase is gaining marked importance due to its potential clinical applications. A variety of microorganisms, including bacteria, yeast, and lamentous fungi, from soil habitat have been reported to produce L-glutaminase.
Bhalchandra B. Waykar, Namekar, Trupti, Rajendra A. Satpute, Dinesh S. Kharate   +3 more
core   +1 more source

Targeting Glutaminase by Natural Compounds: Structure-Based Virtual Screening and Molecular Dynamics Simulation Approach to Suppress Cancer Progression

Molecules, 2022
Cancer cells change their glucose and glutamine (GLU) metabolism to obtain the energy required to continue growing. Glutaminase (GLS) plays a crucial role in promoting cell metabolism for cancer cell growth; targeting GLU metabolism by inhibiting GLS has
Shams Tabrez, Torki A. Zughaibi, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Azhar U. Khan   +5 more
doaj   +1 more source

Identification of Inhibitors of Phosphate-activated Glutaminase for the Pharmacotherapy of Schizophrenia [PDF]

, 2022
In the brain, phosphate-activated glutaminase catalyzes the recycling of glutamine back to glutamate for excitatory neurotransmission. In mice, genetic knockdown of phosphate-activated glutaminase has been shown to confer resilience to schizophrenia-like
Mihali, Andra, Katz, Francine, Sorrento, Cristina, MacDonald, Joanne, Subramani, Shreya, Rayport, Stephen   +5 more
core   +1 more source

Genetic pharmacotherapy as an early CNS drug development strategy: testing glutaminase inhibition for schizophrenia treatment in adult mice

Frontiers in Systems Neuroscience, 2016
Genetic pharmacotherapy is an early drug development strategy for the identification of novel CNS targets in mouse models prior to the development of specific ligands.
Susana eMingote, Susana eMingote, Justine eMasson, Justine eMasson, Celia eGellman, Gretchen Miller Thomsen, Gretchen Miller Thomsen, Chyuan-Sheng eLin, Robert J. Merker, Inna eGaisler-Salomon, Inna eGaisler-Salomon, Yvonne eWang, Rachel eErnst, Rene eHen, Rene eHen, Stephen eRayport, Stephen eRayport   +16 more
doaj   +1 more source