Results 21 to 30 of about 24,633 (278)
The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy [PDF]
Nature Communications, 2016 Cancer cells have previously been shown to be addicted to glutamine and glutaminase enzyme activity. Here, the authors show that overexpression of the JUN proto-oncogene in breast cancer cells regulates glutaminaseexpression and is sufficient to confer ...
Michael J. Lukey +4 more
doaj +2 more sources
Targeting Glutaminase Isoforms GLS and GLS2 in Luminal Breast Cancer. [PDF]
Int J Mol SciUpregulation of glutaminase enzymatic activity promotes tumour cell proliferation. Its overexpression correlates with poor disease outcome in patients, including those with breast cancer.
Masisi BK +5 more
europepmc +2 more sources
Beyond Glycolysis: Targeting Non-Glycolytic Metabolic Pathways in Brain Tumors for Therapeutic Innovation: A Narrative Review. [PDF]
Health Sci RepABSTRACT Background and Aims Metabolic reprogramming is a hallmark of brain tumors, extending beyond the classical Warburg effect. While glycolysis has been extensively studied, gliomas and pediatric high‐grade brain cancers demonstrate remarkable metabolic plasticity.
Mayesha II +5 more
europepmc +2 more sources
Glutaminase inhibition as potential cancer therapeutics: current status and future applications
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Alterations in normal metabolic processes are defining features of cancer. Glutamine, an abundant amino acid in the human blood, plays a critical role in regulating several biosynthetic and bioenergetic pathways that support tumour growth. Glutaminolysis
Rajath Cyriac, Kwangho Lee
semanticscholar +1 more source
Filament formation drives catalysis by glutaminase enzymes important in cancer progression
bioRxiv, 2023 The glutaminase enzymes GAC and GLS2 catalyze the hydrolysis of glutamine to glutamate, satisfying the ‘glutamine addiction’ of cancer cells. They are the targets of anti-cancer drugs; however, their mechanisms of activation and catalytic activity have ...
S. Feng +4 more
semanticscholar +1 more source
High-Throughput Screening Reveals New Glutaminase Inhibitor Molecules
, 2021 The glutaminase (GLS) enzyme hydrolyzes glutamine into glutamate, an important anaplerotic source for the tricarboxylic acid cycle in rapidly growing cancer cells under the Warburg effect.
Cyro von Zuben de Valega Negrao (11777403) +17 more
core +2 more sources
Cancer Letters, 2021 The efficacy of ionizing radiation (IR) for head and neck cancer squamous cell carcinoma (HNSCC) is limited by poorly understood mechanisms of adaptive radioresistance. Elevated glutaminase gene expression is linked to significantly reduced survival (p <
C. A. Wicker +10 more
semanticscholar +1 more source
Science Advances, 2021 When glutamine is limiting, lncRNA GIRGL inhibits glutaminase activity through phase separation to enable cancer cell survival. Glutamine constitutes an essential source of both carbon and nitrogen for numerous biosynthetic processes.
Ruijie Wang +7 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance We report that androgen receptor (AR) promotes glutaminase 1 (GLS1) expression and glutamine utilization to support the survival of prostate cancer (PCa) cells.
Lingfan Xu +20 more
semanticscholar +1 more source
Microglial glutaminase 1 deficiency mitigates neuroinflammation associated depression.
Brain, behavior, and immunity, 2021 Glutaminase 1 (GLS1) has recently been reported to be expressed in microglia and plays a crucial role in neuroinflamation. Significantly increased level of GLS1 mRNA expression together with neuroinflammation pathway were observed in postmortem ...
Chenhui Ji +9 more
semanticscholar +1 more source