Results 21 to 30 of about 15,841 (191)

Genetic pharmacotherapy as an early CNS drug development strategy: testing glutaminase inhibition for schizophrenia treatment in adult mice

Frontiers in Systems Neuroscience, 2016
Genetic pharmacotherapy is an early drug development strategy for the identification of novel CNS targets in mouse models prior to the development of specific ligands.
Susana eMingote, Susana eMingote, Justine eMasson, Justine eMasson, Celia eGellman, Gretchen Miller Thomsen, Gretchen Miller Thomsen, Chyuan-Sheng eLin, Robert J. Merker, Inna eGaisler-Salomon, Inna eGaisler-Salomon, Yvonne eWang, Rachel eErnst, Rene eHen, Rene eHen, Stephen eRayport, Stephen eRayport   +16 more
doaj   +1 more source

Targeting Glutaminase by Natural Compounds: Structure-Based Virtual Screening and Molecular Dynamics Simulation Approach to Suppress Cancer Progression

Molecules, 2022
Cancer cells change their glucose and glutamine (GLU) metabolism to obtain the energy required to continue growing. Glutaminase (GLS) plays a crucial role in promoting cell metabolism for cancer cell growth; targeting GLU metabolism by inhibiting GLS has
Shams Tabrez, Torki A. Zughaibi, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Azhar U. Khan   +5 more
doaj   +1 more source

An Asp to Strike Out Cancer? Therapeutic Possibilities Arising from Aspartate’s Emerging Roles in Cell Proliferation and Survival

Biomolecules, 2021
A better understanding of the metabolic constraints of a tumor may lead to more effective anticancer treatments. Evidence has emerged in recent years shedding light on a crucial aspartate dependency of many tumor types.
Iiro Taneli Helenius, Hanumantha Rao Madala, Jing-Ruey Joanna Yeh   +2 more
doaj   +1 more source

Targeting glutaminase and mTOR

Oncotarget, 2015
Comprehensive genomic and proteomic analyses demonstrate that there is nearly universal activation of the PI3K pathway in glioblastoma (GBM) patients [1]. Persistent PI3K signaling promotes GBM formation and tumor progression in genetic mouse models, establishing PI3K and its effecter mTOR as compelling molecular targets.
Kazuhiro, Tanaka, Takashi, Sasayama, Eiji, Kohmura   +2 more
openaire   +2 more sources

SCREENING AND CHARACTERIZATION OF L-GLUTAMINASE PRODUCED BY BACTERIA ISOLATED FROM SANGIHE TALAUD SEA

Squalen, 2013
L-glutaminase (L-glutamine amidohydrolase, EC 3.5.1.2) is a very important enzyme due to its role as flavor enhancer and antileukemic agent. Salt-tolerant L-glutaminase produced by marine bacteria is favorable in food industries. This study describes the
Ekowati Chasanah, Usman Sumo Friend Tambunan, Tanti Yulianti   +2 more
doaj   +1 more source

SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS

Antioxidants, 2023
Cancer cells show increased glutamine consumption. The glutaminase (GLS) enzyme controls a limiting step in glutamine catabolism. Breast tumors, especially the triple-negative subtype, have a high expression of GLS. Our recent study demonstrated that GLS
Federica Barreca, Michele Aventaggiato, Laura Vitiello, Luigi Sansone, Matteo Antonio Russo, Antonello Mai, Sergio Valente, Marco Tafani   +7 more
doaj   +1 more source

ON THE PRESENCE OF GLUTAMINASE IN MUSCLE [PDF]

Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1969
The glutaminase activity of rat cardiac and skeletal muscle has been investigated, and compared with that of rat kidney. Vmax per g. of protein was 42 µmole/hr for heart muscle homogenates and 478 µmole/hr for kidney homogenates. Glutaminase activity was not detectable in about 50 per cent of the skeletal muscle homogenates; in the other 50 per cent ...
openaire   +2 more sources

CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor

Frontiers in Oncology, 2022
Pyruvate carboxylase (PC) is an important anaplerotic enzyme that replenishes the tricarboxylic acid cycle (TCA) intermediates. It prevents the collapse of the TCA cycle upon its intermediates are removed during high anabolic demand.
Jarunya Ngamkham, Siraprapa Siritutsoontorn, Saowaluk Saisomboon, Kulthida Vaeteewoottacharn, Sarawut Jitrapakdee   +4 more
doaj   +1 more source

GLS (Glutaminase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2019
After metabolic reprogramming, many cancer cells become glutamine addicted, that is, they depend on a high consumption of this amino acid for their survival and proliferation. Glutaminase catalyzes the stoichiometric conversion of L-glutamine to L-glutamate and ammonium ions, the first step of glutaminolysis.
Campos-Sandoval, José A., Martin-Rufián, Mercedes, Márquez, Javier   +2 more
openaire   +2 more sources

Optimization Of Culture Conditions For Maximizing L-glutaminase Production From The Marine Fungus Aspergillus flavus [PDF]

Delta Journal of Science
Marine fungi have the capacity to extreme environments and   live in a highly competitive ecological position make them suppliers of novel metabolites as L-glutaminase   which is medically useful in the pharmaceutical industry, as an antioxidant and ...
Omyma Awadalla, Maha Azab, Hagar Hussien, Abd El-Raheem El-Shanshoury   +3 more
doaj   +1 more source