Results 21 to 30 of about 19,538 (222)

Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma

Clinical and Translational Medicine, 2022
Background Glutaminolysis is a critical metabolic process that promotes cancer cell proliferation, including hepatocellular carcinoma (HCC). Delineating the molecular control of glutaminolysis could identify novel targets to ameliorate this oncogenic ...
Taotao Zhang, Yunlong Cui, Yanjin Wu, Jiahui Meng, Linmeng Han, Jiaqi Zhang, Chunyu Zhang, Chenxi Yang, Lu Chen, Xue Bai, Kai Zhang, Kaiyuan Wu, Michael N. Sack, Lingdi Wang, Lu Zhu   +14 more
doaj   +1 more source

Research Progress in Improving Efficacy of Radiotherapy by Targeting Glutamine Metabolism

Zhongliu Fangzhi Yanjiu, 2023
Radiotherapy is an important treatment method for malignant tumors. Radiation resistance is the main obstacle to the therapeutic effect of radiotherapy. Cellular metabolic reprogramming is one of the main features of cancer, and it may have an important ...
QIAO Wanjia, DONG Na, LIU Xiaojun
doaj   +1 more source

Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes. [PDF]

, 2020
Background: Metabolic reprogramming of tumours is a hallmark of cancer. Among the changes in the metabolic network of cancer cells, glutaminolysis is a key reaction altered in neoplasms. Glutaminase proteins control the first step in glutamine metabolism
Mates-Sánchez, José Manuel, De los Santos-Jiménez, Juan, Márquez-Gómez, Javier, Segura-Checa, Juan Antonio, Alonso-Carrión, Francisco José, Campos-Sandoval, José Ángel   +5 more
core   +1 more source

Understanding gut-liver axis nitrogen metabolism in Fatty Liver Disease

Frontiers in Endocrinology, 2022
The homeostasis of the most important nitrogen-containing intermediates, ammonia and glutamine, is a tightly regulated process in which the gut-liver axis plays a central role.
Teresa C. Delgado, Teresa C. Delgado, Javier de las Heras, Javier de las Heras, Javier de las Heras, María L. Martínez-Chantar, María L. Martínez-Chantar   +6 more
doaj   +1 more source

Glutaminase-free L-asparaginase production by Leucosporidium muscorum isolated from Antarctic marine-sediment

, 2020
L-asparaginase (ASNase) is an essential drug in the treatment of acute lymphoblastic leukemia (ALL). Commercial bacterial ASNases increase patient survival, but the consequent immunological reactions remain a challenge.
Rafael Bertelli Ferraro (9370271), Aldo Tonso (5836421), Lara Durães Sette (9370277), Rominne Karla Barros Freire (9370265), João Henrique Picado Madalena Santos (6325574), Felipe Rebello Lourenço (4652215), Adalberto Pessoa Junior (13192876), Carlos Miguel Nóbrega Mendonça (9370268), Ignacio Sánchez Moguel (9370274)   +8 more
core   +1 more source

Functional Characterisation Of Asparaginase And Glutaminase In Klebsiella Pneumoniae KR3167

, 2019
Asparaginase and glutaminase are sets of enzymes that assist Klebsiella pneumoniae in acquiring necessary nitrogen sources when ammonia (NH3), the preferred nitrogen source, is low or absent. K.
Rashed M. Alghamdi (7741118)
core   +7 more sources

Improving the Production of Salt-Tolerant Glutaminase by Integrating Multiple Copies of Mglu into the Protease and 16S rDNA Genes of Bacillus subtilis 168

Molecules, 2019
In this study, the Micrococcus luteus K-3 glutaminase was successfully over-expressed in the GRAS (Generally Recognized as Safe) Bacillus subtilis strain 168 by integration of the Mglu gene in the 16S rDNA locus. This was done in order to screen a strain
Xian Zhang, Zhaoyang Xu, Song Liu, Kai Qian, Meijuan Xu, Taowei Yang, Jianzhong Xu, Zhiming Rao   +7 more
doaj   +1 more source

Expression of Gls and Gls2 glutaminase isoforms in astrocytes [PDF]

, 2015
The expression of glutaminase in glial cells has been a controversial issue and matter of debate for many years. Actually, glutaminase is essentially considered as a neuronal marker in brain.
Mates-Sánchez, José Manuel, Francisco J. Alonso, Segura, Juan A, Elisabeth Sánchez‐Mejías, Jayakumar, Arumugan, Rama Rao, Kakulavarapu V., Michael D. Norenberg, Antonia Gutiérrez, Dávila, José C, Norenberg, Michael, José C. Dávila, José A. Campos‐Sandoval, Martín-Rufián, Mercedes, Kakulavarapu V. Rama Rao, Gutiérrez-Pérez, Antonia, Gutiérrez, Antonia, Sánchez-Mejías, Elisabeth, Mercedes Martín‐Rufián, Norenberg, Michael D., Cardona, Carolina, Javier Márquez, Jayakumar, Arumugan R, Alonso-Carrión, Francisco José, Vitorica Ferrández, Javier, Campos-Sandoval, José Ángel, Martín‐Rufián, Mercedes, Matés, José M, Javier Vitorica, Arumugan R. Jayakumar, Segura-Checa, Juan Antonio, Rama Rao, Kakulavarapu V, Sánchez‐Mejías, Elisabeth, Campos‐Sandoval, José A, Dávila-Cansino, José Carlos, Norenberg, Michael D, Rama Rao, Kakulavarapu, José M. Matés, Vitorica, Javier, Márquez-Gómez, Javier, Juan A. Segura, Márquez, Javier, Carolina Cardona, Alonso, Francisco J, Jayakumar, Arumugan R.   +43 more
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GMP Synthetase: Allostery, Structure, and Function

Biomolecules, 2023
Glutamine amidotransferases (GATs) catalyze the hydrolysis of glutamine and transfer the generated ammonia to diverse metabolites. The two catalytic activities, glutaminolysis and the subsequent amination of the acceptor substrate, happen in two distinct
Lionel Ballut, Sébastien Violot, Sanjeev Kumar, Nushin Aghajari, Hemalatha Balaram   +4 more
doaj   +1 more source

Cocaine modulates both glutaminase gene expression and glutaminase activity in the brain of cocaine-sensitized mice [PDF]

, 2011
Glutaminase is considered the main Glutamate (Glu) producing enzyme. Two isoforms, liver (LGA) and kidney (KGA) type glutaminases have been identified in neurons.
José Ángel Campos-Sandoval, Palomino, Ana, Ana Palomino, Ainhoa Bilbao, Juan Suárez, Luque-Rojas, María Jesús, María Jesús Luque-Rojas, Fernando Rodríguez de Fonseca, Blanco-Calvo, Eduardo, Eduardo Blanco, Márquez-Gómez, Javier, Bilbao, Ainhoa, Javier Márquez, Suárez, Juan, Rodriguez-de-Fonseca, Fernando, Campos-Sandoval, José Ángel   +15 more
core   +1 more source