Results 71 to 80 of about 15,841 (191)

Comparing Early Graft Dysfunction Scores in Liver Transplantation After Ex‐Situ Normothermic Machine Perfusion

Clinical Transplantation, Volume 40, Issue 8, August 2026.
ABSTRACT Introduction As normothermic machine perfusion (NMP) maintains liver grafts in a near‐physiologic state, uncoupling ischemia–reperfusion injury from the recipient, the validity of early graft dysfunction scores from the static cold storage (SCS) era are uncertain.
Kejal Shah, Sydney Castellanos, April J. Logan, Leonid Gorelik, Annelise Nolan, Manoj Iyer, Lauren Von Stein, Wei Chen, Ayato Obana, Ashley Limkemann, Navdeep Singh, Sylvester Black, William K. Washburn, Austin D. Schenk, Musab Alebrahim, Sai Rithin Punjala   +15 more
wiley   +1 more source

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

Amino acid homeostasis in the kidney: Physiological roles and pathological dysregulation

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract Amino acids are fundamental to life as protein building blocks and key regulators of metabolism and signaling. The kidney plays a critical, yet underappreciated, role in amino acid homeostasis through three interconnected pillars: selective glomerular filtration, efficient tubular reabsorption, and metabolic processing, which includes de novo ...
Shuo Liu, Caifeng Shi, Yang Zhou, Chunsun Dai   +3 more
wiley   +1 more source

Glutaminase Increases in Rat Dorsal Root Ganglion Neurons after Unilateral Adjuvant-Induced Hind Paw Inflammation

Biomolecules, 2016
Glutamate is a neurotransmitter used at both the peripheral and central terminals of nociceptive primary sensory neurons, yet little is known concerning regulation of glutamate metabolism during peripheral inflammation.
E. Matthew Hoffman, Zijia Zhang, Ruben Schechter, Kenneth E. Miller   +3 more
doaj   +1 more source

Glutaminase inhibition as potential cancer therapeutics: current status and future applications

Journal of Enzyme Inhibition and Medicinal Chemistry
Alterations in normal metabolic processes are defining features of cancer. Glutamine, an abundant amino acid in the human blood, plays a critical role in regulating several biosynthetic and bioenergetic pathways that support tumour growth. Glutaminolysis
Rajath Cyriac, Kwangho Lee
doaj   +1 more source

Dual targeting of EGFR and glutaminase in lung cancer

Molecular & Cellular Oncology, 2018
We have recently demonstrated that targeted inhibition of epidermal growth factor receptor (EGFR) signaling and glutaminase led to metabolic crisis in EGFR mutant lung adenocarcinomas and significant tumor regression in mouse xenograft models.
Milica Momcilovic, David B. Shackelford
doaj   +1 more source

Glutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6

Molecular & Cellular Oncology, 2019
Understanding and overcoming resistance to cyclin-dependent kinase 4/6 (CDK4/6) inhibitors will be challenging. Recent work reveals that dysregulation of F-Box Protein 4 (FBXO4)-Cyclin D1 axis leads to mitochondrial dysfunction and drives glutamine ...
Shuo Qie, J. Alan Diehl
doaj   +1 more source

An Overview of Asparaginase Enzyme Features: An Anticancer Enzyme with High Potency

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2019
Introduction: One of the important findings in the pharmaceutical and medical industry is the use of the asparaginazase enzyme as an anticancer drug. The asparaginase enzyme, hydrolyzing the amino acid of asparagine, reduces this amino acid in the blood ...
Gholam Hossein Ebrahimipour, Mahtab Ghorban Movahed   +1 more
doaj  

Safety evaluation of the food enzyme glutaminase from the non‐genetically modified Bacillus amyloliquefaciens strain AE‐GT

EFSA Journal
The food enzyme glutaminase (l‐glutamine amidohydrolase; EC 3.5.1.2) is produced with the non‐genetically modified Bacillus amyloliquefaciens strain AE‐GT by Amano Enzyme Inc.
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Vittorio Silano, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Claude Lambré, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu, Simone Lunardi, Elsa Nielsen, Karin Norby, Giulio diPiazza, Yrjö Roos, Andrew Chesson   +26 more
doaj   +1 more source

Alpha and Omega Classification of β-Lactamase/Transpeptidase-like Superfamily Proteins Based on the Comparison of Their Structural Catalytic Cores

Molecules
β-Lactamase/transpeptidase-like superfamily proteins are serine proteases that use the Ser–Lys catalytic dyad to carry out their biological functions. Here, we investigate the three known families of β-lactamase/transpeptidase-like superfamily proteins ...
Alexander I. Denesyuk, Konstantin Denessiouk, Mark S. Johnson, Vladimir N. Uversky   +3 more
doaj   +1 more source