Results 81 to 90 of about 20,010 (192)

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Production, optimization and characterization of L-glutaminase from marine bacteria [PDF]

, 2019
L-glutaminase present in living organisms. L-glutaminase has been identified having potential applications for several industries including pharmaceutical, food, and health care.
Nur Dini, Johari
core   +1 more source

Nutrient‐specific combinatorial secretion of GLP‐1 and neurotransmitters in the enteroendocrine L‐cell line GLUTag

The FEBS Journal, EarlyView.
Enteroendocrine L cells function as chemosensors in the intestine. Using the L‐cell line GLUTag, we show that distinct nutrients trigger different combinations of co‐secretion of GLP‐1 and neurotransmitters: D‐glucose evokes GLP‐1, glutamate, and ATP; L‐glutamine evokes GLP‐1 and glutamate; sucralose and butyrate evoke only GLP‐1.
Yo Ito, Kazuki Harada, Yuri Osuga‐Yoshiike, Masami Yokota Hirai, Tetsuya Kitaguchi, Takashi Tsuboi   +5 more
wiley   +1 more source

Characterization of a New L-Glutaminase Produced by Achromobacter xylosoxidans RSHG1, Isolated from an Expired Hydrolyzed L-Glutamine Sample

, 2021
As significant biocatalyst, L-glutaminases find potential applications in various fields, from nourishment to the pharmaceutical industry. Anticancer activity and flavor enhancement are the most promising applications of L-glutaminases.
Safia Ahmed, Rabia Saleem
core   +1 more source

Metabolic‐Epigenetic Coupling in Aortic Aneurysm and Aortic Dissection: GLS1 and SLC1A5 as Guardians of VSMC Homeostasis

iNew Medicine, EarlyView.
Yu Zeng, Jifeng Zhang, Haocheng Lu
wiley   +1 more source

Hypercapnia Induces Mitochondrial Adaptations and Alters Glutamine Metabolism to Drive a Distinct Metabolic Phenotype in Monocytes

Immunology &Cell Biology, EarlyView.
Elevated CO2 (hypercapnia) is a feature of serious lung diseases, for example COPD and contributes to poor patient prognosis through modulation of immune cell function. Here we employ state‐of‐the art metabolomic and isotope tracing approaches to reveal CO2‐dependent mitochondrial alterations linked to suppressed ATP, proline and glutamate levels in ...
Ben Reddan, David E. Phelan, Xiaofei Yin, Lorraine Brennan, Martina Wallace, Eoin P. Cummins   +5 more
wiley   +1 more source

De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition

Molecular Systems Biology, 2017
Cyclin‐dependent kinases (CDK) are rational cancer therapeutic targets fraught with the development of acquired resistance by tumor cells. Through metabolic and transcriptomic analyses, we show that the inhibition of CDK4/6 leads to a metabolic ...
Míriam Tarrado‐Castellarnau, Pedro de Atauri, Josep Tarragó‐Celada, Jordi Perarnau, Mariia Yuneva, Timothy M Thomson, Marta Cascante   +6 more
doaj   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Isolasi Dan Skrining Bakteri Endofit Penghasil Enzim L-Glutaminase Dari Mangrove (Sonneratia Alba) [PDF]

, 2017
Enzim L-glutaminase merupakan enzim yang mengkatalisis dan hidrolisis dari L-glutamin menjadi L-glutamat dan ammonia. Enzim ini dapat dimanfaatkan untuk kesehatan dan pangan.
Ningrum, Fifta Frizki Setya
core  

Pentacyclic triterpene acids, rotungenic acid and barbinervic acid, from fresh leaves of Diospyros kaki Thunberg and their glutaminase inhibitory activities

, 2022
Glutaminase is an important target that is often over-expressed in neurodegenerative and lifestyle-related diseases but few effective inhibitors of this enzyme have yet reached clinical trials. Three compounds isolated from fresh leaves of Diospyros kaki
Masanori Inagaki (3926675), Atsumi Shimada (9267298), Kohei Kawabata (14179496), Hiroshi Ueno (416056), Kenta Yamamoto (4837557)   +4 more
core   +1 more source