Results 81 to 90 of about 19,538 (222)

Histochemical localization of glutaminase I activity in kidney

, 1961
A histochemical method is described for the demonstration of glutaminase I in sections of fresh frozen tissue cut in the cryostat. The application of this method to the kidney of the golden hamster revealed extremely high activity of glutaminase I in ...
Morris J. Karnovsky, S. Ralph Himmelhoch
core   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

Glutaminase Expression in Canine Large‐Cell Alimentary Lymphoma Cells and Effects of Glutaminase Inhibition by CB‐839

Veterinary Medicine and Science
Glutamine metabolism plays a crucial role in tumour progression, making glutaminase a promising therapeutic target in various human cancers. However, its role in canine large‐cell alimentary lymphoma (AL) remains unclear.
Kosei Sakai, Masaki Hirao, Satoshi Kameshima, Yasuhiko Okamura, Takuya Mizuno, Shunsuke Shimamura   +5 more
doaj   +1 more source

Detection of Pancreatic Cancer via Specific Metabolite Markers: A Metabolomics Approach

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies worldwide because most patients are diagnosed at advanced stages when curative treatment is no longer feasible. Metabolomics has emerged as a promising strategy for identifying biochemical alterations associated with early tumor development ...
Mohammad Javad Roustaye Gourabi, Mehrangiz Ghafari, Anita Nikoo, Yalda Yarahmadi Saki, Bita Khanbabaei, Masoumeh Khanizadeh, Masoud Kargar, Ali Hashemi, Javad Yasbolaghi Sharahi   +8 more
wiley   +1 more source

Hormonal regulation of hepatic glutaminase

, 1994
Liver glutaminase, a mitochondrial enzyme, is known to be activated by hormones such as glucagon. Diabetes mellitus is a metabolic disease which is characterized by alterations in the insulin:glucagon ratio and, therefore, represents an in vivo ...
Squires, Stephen Arthur
core  

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition

Molecular Systems Biology, 2017
Cyclin‐dependent kinases (CDK) are rational cancer therapeutic targets fraught with the development of acquired resistance by tumor cells. Through metabolic and transcriptomic analyses, we show that the inhibition of CDK4/6 leads to a metabolic ...
Míriam Tarrado‐Castellarnau, Pedro de Atauri, Josep Tarragó‐Celada, Jordi Perarnau, Mariia Yuneva, Timothy M Thomson, Marta Cascante   +6 more
doaj   +1 more source

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang, Yin Zhu, Fang Xu, Yongjing Liu, Yuan Li, Ling Yuan, Liqin Wei, Bo Huang, Yan Chen, Pei Huang, Zuochen Du   +10 more
wiley   +1 more source

Tissue trans-glutaminase antibody in Inflammatory Bowel Disease in Golestan province, Northern Iran (2005-08)

مجله دانشگاه علوم پزشکی گرگان, 2011
Background and Objective: Celiac is a hereditary disease presented with chronic inflammation of small intestine. Several studies supposed a relationship between Celiac disease and Inflammatory Bowel Disease (IBD). Tissue trans-glutaminase antibody is one
Amiriani T, Besharat S, Semnani Sh, Joshaghani HR, Roshandel GhR, Keshtkar AA, Kiaii MR, Mirkarimi HS, Hashemi-Nasab SZ, Zendeh-Bad AS   +9 more
doaj  

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source