Results 81 to 90 of about 24,633 (278)

An Asp to Strike Out Cancer? Therapeutic Possibilities Arising from Aspartate’s Emerging Roles in Cell Proliferation and Survival

Biomolecules, 2021
A better understanding of the metabolic constraints of a tumor may lead to more effective anticancer treatments. Evidence has emerged in recent years shedding light on a crucial aspartate dependency of many tumor types.
Iiro Taneli Helenius, Hanumantha Rao Madala, Jing-Ruey Joanna Yeh   +2 more
doaj   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Inhibition of the MYC-regulated glutaminase metabolic axis is an effective synthetic lethal approach for treating chemoresistant cancers

Cancer Research, 2020
Targeting glutaminase disturbs redox homeostasis and nucleotide synthesis and causes replication stress in cancer cells, representing an exploitable vulnerability for the development of effective therapeutics.
Y. Shen, Jiaxin Hong, R. Asaka, S. Asaka, Fang-Chi Hsu, Y. Suryo Rahmanto, J. Jung, Yu-Wei Chen, T. Yen, Alicja Tomaszewski, Cissy Zhang, Nabeel Attarwala, A. DeMarzo, B. Davidson, C. Chuang, Xi Chen, S. Gaillard, A. Le, I. Shih, Tian-Li Wang   +19 more
semanticscholar   +1 more source

SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS

Antioxidants, 2023
Cancer cells show increased glutamine consumption. The glutaminase (GLS) enzyme controls a limiting step in glutamine catabolism. Breast tumors, especially the triple-negative subtype, have a high expression of GLS. Our recent study demonstrated that GLS
Federica Barreca, Michele Aventaggiato, Laura Vitiello, Luigi Sansone, Matteo Antonio Russo, Antonello Mai, Sergio Valente, Marco Tafani   +7 more
doaj   +1 more source

Asparaginase and Glutaminase Activities of Bacteria [PDF]

Journal of General Microbiology, 1971
SUMMARY: A test-tube method is described for the determinations of L-asparaginase and L-glutaminase in suspensions and extracts of bacteria. An automated modification of the method was used to determine the asparaginase activities of about 200 strains from 78 species and the glutaminase activities of 46 strains from 13 species. Both enzymes were widely
H E, Wade, H K, Robinson, B W, Phillips
openaire   +2 more sources

Structure and activation mechanism of the human liver-type glutaminase GLS2

Biochimie, 2021
Cancer cells exhibit an altered metabolic phenotype, consuming higher levels of the amino acid glutamine. This metabolic reprogramming depends on increased mitochondrial glutaminase activity to convert glutamine to glutamate, an essential precursor for ...
I. Ferreira, J. E. N. Quesñay, Alliny C S Bastos, C. T. Rodrigues, M. Vollmar, T. Krojer, C. Strain-Damerell, N. Burgess-Brown, F. von Delft, W. Yue, Sandra M G Dias, A. L. Ambrosio   +11 more
semanticscholar   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Glutaminase in microglia: a novel regulator of neuroinflammation.

Brain, behavior, and immunity, 2020
Neuroinflammation is the inflammatory responses that are involved in the pathogenesis of most CNS disorders. Glutaminase (GLS) is the enzyme that catalyzes the hydrolysis of glutamine to produce glutamate.
Lu Ding, Xiaonan Xu, Congcong Li, Yi Wang, Xiaohuan Xia, Jialin C. Zheng   +5 more
semanticscholar   +1 more source

Identification and characterization of a novel glutaminase inhibitor

FEBS Open Bio, 2021
In humans, there are two forms of glutaminase (GLS), designated GLS1 and GLS2. These enzymes catalyse the conversion of glutamine to glutamate. GLS1 exists as two isozymes: kidney glutaminase (KGA) and glutaminase C (GAC).
Henning Cederkvist, Shrikant S Kolan, J. A. Wik, Z. Şener, B. Skålhegg   +4 more
semanticscholar   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source