Results 101 to 110 of about 20,010 (192)
Glutaminase inhibition as potential cancer therapeutics: current status and future applications
Journal of Enzyme Inhibition and Medicinal ChemistryAlterations in normal metabolic processes are defining features of cancer. Glutamine, an abundant amino acid in the human blood, plays a critical role in regulating several biosynthetic and bioenergetic pathways that support tumour growth. Glutaminolysis
Rajath Cyriac, Kwangho Lee
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Liver International, Volume 46, Issue 11, November 2026.ABSTRACT Ammonia is a nitrogenous molecule which is primarily generated in the gastrointestinal tract. The neurotoxicity of ammonia plays a critical role in the liver's regulation of circulating ammonia levels. In liver disease, an increase in blood ammonia has been long implicated in the pathogenesis of hepatic encephalopathy (HE), a neurological ...
Maria Pilar Ballester +2 more
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-glutaminase activity in marine sediments
, 1977 168-170Mangrove sediments exhibited higher activity of -glutaminase (-glutamine aminohydrolase, EC 3.5, 1.2) compared to sediments collected from other biotopes. Clayey sediments showed higher enzyme activity than the silty ones.
Natarajan, R. +3 more
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Histochemical localization of glutaminase I activity in kidney
, 1961 A histochemical method is described for the demonstration of glutaminase I in sections of fresh frozen tissue cut in the cryostat. The application of this method to the kidney of the golden hamster revealed extremely high activity of glutaminase I in ...
Morris J. Karnovsky, S. Ralph Himmelhoch
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Dual targeting of EGFR and glutaminase in lung cancer
Molecular & Cellular Oncology, 2018 We have recently demonstrated that targeted inhibition of epidermal growth factor receptor (EGFR) signaling and glutaminase led to metabolic crisis in EGFR mutant lung adenocarcinomas and significant tumor regression in mouse xenograft models.
Milica Momcilovic, David B. Shackelford
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Glutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6
Molecular & Cellular Oncology, 2019 Understanding and overcoming resistance to cyclin-dependent kinase 4/6 (CDK4/6) inhibitors will be challenging. Recent work reveals that dysregulation of F-Box Protein 4 (FBXO4)-Cyclin D1 axis leads to mitochondrial dysfunction and drives glutamine ...
Shuo Qie, J. Alan Diehl
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An Overview of Asparaginase Enzyme Features: An Anticancer Enzyme with High Potency
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2019 Introduction: One of the important findings in the pharmaceutical and medical industry is the use of the asparaginazase enzyme as an anticancer drug. The asparaginase enzyme, hydrolyzing the amino acid of asparagine, reduces this amino acid in the blood ...
Gholam Hossein Ebrahimipour +1 more
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EFSA JournalThe food enzyme glutaminase (l‐glutamine amidohydrolase; EC 3.5.1.2) is produced with the non‐genetically modified Bacillus amyloliquefaciens strain AE‐GT by Amano Enzyme Inc.
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) +26 more
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Moleculesβ-Lactamase/transpeptidase-like superfamily proteins are serine proteases that use the Ser–Lys catalytic dyad to carry out their biological functions. Here, we investigate the three known families of β-lactamase/transpeptidase-like superfamily proteins ...
Alexander I. Denesyuk +3 more
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, 2015 A Bacillus amyloliquefaciens strain SWJS22 isolated from deep sea mud of the South China Sea was used to produce glutaminase by solid-state fermentation.
Chihongling, ZHOU +2 more
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