Results 101 to 110 of about 24,633 (278)
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source
Production, optimization and characterization of L-glutaminase from marine bacteria [PDF]
, 2019 L-glutaminase present in living organisms. L-glutaminase has been identified having potential applications for several industries including pharmaceutical, food, and health care.
Nur Dini, Johari
core
Histochemical localization of glutaminase I activity in kidney
, 1961 A histochemical method is described for the demonstration of glutaminase I in sections of fresh frozen tissue cut in the cryostat. The application of this method to the kidney of the golden hamster revealed extremely high activity of glutaminase I in ...
Morris J. Karnovsky, S. Ralph Himmelhoch
core +1 more source
Biomolecules, 2016 Glutamate is a neurotransmitter used at both the peripheral and central terminals of nociceptive primary sensory neurons, yet little is known concerning regulation of glutamate metabolism during peripheral inflammation.
E. Matthew Hoffman +3 more
doaj +1 more source
The FEBS Journal, EarlyView.Vitamin B6 is a critical molecule for plant metabolism and development. Rsr4‐1, a loss‐of‐function mutant in a vitamin B6 biosynthesis gene, has a distinct short root phenotype. Here we describe five novel suppressor mutants with an rsr4‐1 background that have normalized root growth and distinct phenotypic and molecular characteristics, representing a ...
Marcelina Parra +4 more
wiley +1 more source
Erastin-like anti-Warburg compounds X1 and X4 are GLS2-selective covalent glutaminase inhibitors
The Warburg effect is a metabolic alteration in cancer cells characterized by aerobic glycolysis and lactate production. A recent phenotypic screen for compounds that reverse Warburg metabolism identified two compounds, X1 and X4, that restore the ...
Morgan, Miele +5 more
core +1 more source
, 2023 L-glutaminase is gaining marked importance due to its potential clinical applications. A variety of microorganisms, including bacteria, yeast, and lamentous fungi, from soil habitat have been reported to produce L-glutaminase.
Bhalchandra B. Waykar +3 more
core +1 more source
EBioMedicine, 2018 Background Hepatocellular carcinoma (HCC) is an aggressive malignant disease with poor prognosis. Recent advances suggest the existence of cancer stem cells (CSCs) within liver cancer, which are considered to be responsible for tumor relapse, metastasis,
Binghua Li +10 more
semanticscholar +1 more source
The Efficacy of Food‐Grade Substances to Protect Dietary Glutamine From Ruminal Degradation
Journal of Animal Physiology and Animal Nutrition, EarlyView.ABSTRACT This study was conducted to investigate the use of four, low cost, food‐grade substances to protect glutamine from microbial degradation in vitro, and subsequently validate their efficacy in vivo. Two in vitro trials were conducted using 250 mL bottles replicated in triplicate to test beeswax‐, paraffin wax‐, zein‐, and rice bran wax ...
Lillian P. Carlyon +5 more
wiley +1 more source
Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases
Obesity Reviews, EarlyView.ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar +4 more
wiley +1 more source