Results 91 to 100 of about 24,633 (278)

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

, 2010
SummaryRho GTPases impact a number of activities important for oncogenesis. We describe a small molecule inhibitor that blocks oncogenic transformation induced by various Rho GTPases in fibroblasts, and the growth of human breast cancer and B lymphoma ...
Chi V. Dang, Ambrosio, Andre L.B., Sandra M.G. Dias, Erickson, Jon W., Gao, Ping, Dinavahi, Ramani, Wang, Jian-Bin, Jian-Bin Wang, Fuji, Reina, Wilson, Kristin F., Ramachandran, Sekar, Dias, Sandra M.G., Kristin F. Wilson, Sekar Ramachandran, Dang, Chi V., Ramani Dinavahi, Cerione, Richard A., Richard A. Cerione, Jon W. Erickson, Ping Gao, Reina Fuji, Andre L.B. Ambrosio   +21 more
core   +1 more source

CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor

Frontiers in Oncology, 2022
Pyruvate carboxylase (PC) is an important anaplerotic enzyme that replenishes the tricarboxylic acid cycle (TCA) intermediates. It prevents the collapse of the TCA cycle upon its intermediates are removed during high anabolic demand.
Jarunya Ngamkham, Siraprapa Siritutsoontorn, Saowaluk Saisomboon, Kulthida Vaeteewoottacharn, Sarawut Jitrapakdee   +4 more
doaj   +1 more source

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

Journal of Medicinal Chemistry, 2020
Inhibition of glutaminase-1 (GLS-1) hampers the proliferation of tumor cells reliant on glutamine. Known glutaminase inhibitors have potential limitations, and in vivo exposures are potentially limited due to poor physicochemical properties. We initiated
M. Soth, K. Le, M. E. Di Francesco, M. Hamilton, Gang Liu, Jason P. Burke, C. Carroll, Jeffrey J Kovacs, Jennifer P Bardenhagen, C. Bristow, M. Cardozo, B. Czako, E. de Stanchina, Ningping Feng, J. Garvey, J. Gay, M. Do, J. Greer, Michelle Han, A. Harris, Zachary Herrera, Sha-Hua Huang, V. Giuliani, Yongying Jiang, Sarah B. Johnson, T. Johnson, Zhijun Kang, P. Leonard, Zhen Liu, Timothy J. McAfoos, Meredith A. Miller, Pietro Morlacchi, Robert A. Mullinax, W. Palmer, Jihai Pang, Norma Rogers, C. Rudin, Hannah E Shepard, N. Spencer, Jay P Theroff, Qi Wu, A. Xu, J. Yau, G. Draetta, C. Toniatti, T. Heffernan, Philip Jones   +46 more
semanticscholar   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

L-glutaminase synthesis by Klebsiella pneumoniae (AS KP 23) isolated from clinical strain, and its efficacy against human hepatocellular and breast cancer cell lines

BMC Microbiology
Background Cancer is a major cause of morbidity and mortality worldwide. The proliferation of cancer cells depends largely on glutamine for survival and proliferation.
Lina J. Abdel-Hafez, Eman Y. T. Elariny, Asmaa E. Ibrahim, Mahmoud E. F. Abdel-Haliem   +3 more
doaj   +1 more source

Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma

Cancer & Metabolism, 2020
Osteosarcoma (OS) is a malignant bone tumor that often develops during the period of rapid growth associated with adolescence. Despite successful primary tumor control accompanied by adjuvant chemotherapy, death from pulmonary metastases occurs in ...
L. Ren, V. Ruiz-Rodado, Tyrone Dowdy, S. Huang, Sameer H Issaq, J. Beck, Herui Wang, C. T. Hoang, A. Lita, Mioara Larion, A. LeBlanc   +10 more
semanticscholar   +1 more source

Effect of Salinity Stress on Gut–Brain–Gonad Axis in the Red‐Eared Slider (Trachemys scripta elegans)

Integrative Zoology, EarlyView.
The increase in salinity leads to changes in the gut microbiota and metabolites of Trachemys scripta elegans, affecting the synthesis and secretion of neurotransmitters or precursors, which can inhibit the secretion of reproductive hormones and affect the self‐renewal and differentiation process of spermatogonial stem cells.
Qiongyu Zhang, Na Li, Xue Tang, Hanru Chen, Meiling Hong, Li Ding   +5 more
wiley   +1 more source

SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The mitochondrial enzyme glutaminase (GLS) is frequently up-regulated in cancer cells, and a GLS-selective inhibitor is being evaluated in clinical trials.
K. Greene, Michael J. Lukey, Xueying Wang, Bryant S. Blank, J. Druso, M. Lin, Clint A. Stalnecker, Chengliang Zhang, Yashira L Negrón Abril, J. Erickson, K. Wilson, Hening Lin, R. Weiss, R. Cerione   +13 more
semanticscholar   +1 more source

From Cold to Hot: Nanozyme‐Based Strategies for Reprogramming the Tumour Immunoenvironment

Cell Proliferation, EarlyView.
Nanozymes, with multi‐enzyme catalytic activities, reprogram the immunosuppressive tumour microenvironment by inducing immunogenic cell death, relieving hypoxia, and depleting antioxidants, effectively converting immunologically “cold” tumours into “hot” ones to boost cancer immunotherapy efficacy.
Yue Wang, Miao Xu, Yongshun Wang, Xuan Lin, Qiang Zhang, Xiaoning Lin, Xin Wu, Cheng Zhang, Wenhua Huang, Jianlin Shen   +9 more
wiley   +1 more source

Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth.

Cell Chemical Biology, 2019
Cancer cells sustain growth by altering their metabolism to accelerated aerobic glycolysis accompanied by increased glucose demand and employ glutamine as additional nutrient source.
Elena S Reckzeh, George Karageorgis, M. Schwalfenberg, Javier Ceballos, Jessica Nowacki, Marcus C. M. Stroet, Aylin Binici, Lena Knauer, Silke Brand, A. Choidas, C. Strohmann, Slava Ziegler, H. Waldmann   +12 more
semanticscholar   +1 more source