Results 91 to 100 of about 27,569 (215)

Alpha and Omega Classification of β-Lactamase/Transpeptidase-like Superfamily Proteins Based on the Comparison of Their Structural Catalytic Cores

Molecules
β-Lactamase/transpeptidase-like superfamily proteins are serine proteases that use the Ser–Lys catalytic dyad to carry out their biological functions. Here, we investigate the three known families of β-lactamase/transpeptidase-like superfamily proteins ...
Alexander I. Denesyuk, Konstantin Denessiouk, Mark S. Johnson, Vladimir N. Uversky   +3 more
doaj   +1 more source

Glutamate Metabolism in Brain Structures in Experimental Hemorrhagic Shock

Общая реаниматология, 2017
Purpose. To study glutamate metabolism characteristics in phylogenetically different parts of the mammalian brain in experimentally induced hemorrhagic shock (HS) in cats.Material and methods. Experiments were performed on 76 cats.
V. N. Jakovlev, P. N. Savilov, Y. V. Bulgakova   +2 more
doaj   +1 more source

Optimised Sample Preparation for Metabolic Analysis of Cell Cultures Using DESI‐MS

Chemistry–Methods, Volume 6, Issue 4, April 2026.
Cell pellets are washed once with a 1:1 PBS/AA mixed solution for desalting and pipetted directly onto a reversed‐phase TLC slide as discrete spots and then analysed by desorption electrospray ionisation mass spectrometry imaging (DESI‐MSI). The same slide can be re‐measured for different mass ranges/acquisition modes, enabling comprehensive targeted ...
Wei Chen, Chiara Urban, Hakan Taskiran, Chenyue Dai, Kıvanç Görgülü, Julia Jellusova, Nicole Strittmatter   +6 more
wiley   +1 more source

TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. [PDF]

, 2016
A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly characterized. TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces
Bartrons, Ramon, Birbe, Ruth C., Capparelli, Claudia, Caro, Jaime, Curry, Joseph M., Domingo-Vidal, Marina, Ko, Ying-Hui, Lin, Zhao, Manzano, Anna, Martinez-Outshoorn, Ubaldo E., Navarro-Sabaté, Àurea, Roche, Megan, Seifert, Erin, Tassone, Patrick, Tuluc, Madalina, Whitaker-Menezes, Diana   +15 more
core   +2 more sources

The role of T cells in sepsis of distinct infectious aetiologies

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Pathogen‐specific sepsis induces mitochondrial dysfunction in T cells, leading to functional alterations. Single‐cell transcriptomics reveals subtype‐specific impairments involving reactive oxygen species accumulation, mtDNA damage, calcium dysregulation, and metabolic reprogramming.
Xuanqi Liu, Bijun Zhu, Wanxin Duan, Ruixiang Kang, Xiangdong Wang, Liyang Li   +5 more
wiley   +1 more source

Targeting the muscle for the treatment and prevention of hepatic encephalopathy [PDF]

, 2016
Muscle mass loss or sarcopenia is a principle component of malnutrition which prevails in 65–90% of patients with end-stage liver disease [1]. Intuitively, the roots of malnutrition play a precipitating role in muscle catabolism.
Bémeur, Chantal, Rombouts, Krista, Rose, Christopher   +2 more
core   +2 more sources

NDUFS1‐Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation

MedComm, Volume 7, Issue 4, April 2026.
Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Xin‐Yu Fan, Wen Li, Ying Shi, Bao‐Qing Xu, Hao Wang, Ruo‐Fei Tian, Zi‐Chuan Duan, Jing Fan, Jia‐Rong Liu, Xiu‐Xuan Sun, Bin Wang, Li‐Juan Wang, Ke Wang, Shi‐Jie Wang, Xiang‐Min Yang, Hong‐Yong Cui, Zhi‐Nan Chen, Ling Li   +17 more
wiley   +1 more source

GLS loss of function causes autosomal recessive spastic ataxia and optic atrophy. [PDF]

, 2018
We describe a consanguineous family in which two brothers were affected by childhood onset spastic ataxia with optic atrophy and loss of motor and language skills. Through a combination of homozygosity mapping and whole-genome sequencing, we identified a
Bayat, Dor, Engert, Layer, Masson, Mencacci, Pierson, Seelow, Trabzuni, Wang   +9 more
core   +2 more sources

Isocitrate Dehydrogenase‐Mutant Astrocytomas: Risk Stratification and Therapeutic Advance

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract synthesizes the core logic of our revised review by linking integrated diagnosis, risk stratification, and trajectory‐based management in IDH‐mutant astrocytomas across CNS WHO Grades 2–4. It highlights lineage‐defining molecular classification (IDH mutation with core co‐alterations), integrated histomolecular grading, and key ...
Shepeng Wei, Xuxu Xu, Jing Bao, Zhenjiang Pan   +3 more
wiley   +1 more source

De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition

Molecular Systems Biology, 2017
Cyclin‐dependent kinases (CDK) are rational cancer therapeutic targets fraught with the development of acquired resistance by tumor cells. Through metabolic and transcriptomic analyses, we show that the inhibition of CDK4/6 leads to a metabolic ...
Míriam Tarrado‐Castellarnau, Pedro de Atauri, Josep Tarragó‐Celada, Jordi Perarnau, Mariia Yuneva, Timothy M Thomson, Marta Cascante   +6 more
doaj   +1 more source