Results 111 to 120 of about 20,010 (192)

Neonatal Encephalopathy due to Glutaminase Deficiency in a Neonate

Clinical Case Reports
Identifying neurometabolic disorders that lead to neonatal encephalopathy is difficult, and access to exome sequencing is a significant advantage in developing countries.
Unnati Achanta, Shrinidhi Krishnan, Ashok Chandrasekaran, Robert Wilson S, Senthil Kumar Aiyappan, Subash Sundar   +5 more
doaj   +1 more source

Role of dorsal root ganglion glutaminase in acute and chronic inflammatory pain [PDF]

, 2013
Scope and methods of the study.The purpose of this study was to provide further evidence to support the concept that dorsal root ganglion (DRG) glutaminase, the synthetic enzyme for the neurotransmitter glutamate, is a potential target for analgesic ...
Zhang, Zijia
core  

Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing

, 1999
Elgadi, Khaled M., Robert A. Meguid, Ming Qian, Wiley W. Souba, and Steve F. Abcouwer. Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing. Physiol. Genomics 1: 51–62, 1999.—Three human glutaminase (
MING QIAN, KHALED M. ELGADI, STEVE F. ABCOUWER, ROBERT A. MEGUID, WILEY W. SOUBA   +4 more
core   +1 more source

Assembly of the eukaryotic PLP-synthase complex from plasmodium and activation of the Pdx1 enzyme

, 2012
Biosynthesis of vitamins is fundamental to malaria parasites. Plasmodia synthesize the active form of vitamin B6 (pyridoxal 5-phosphate, PLP) using a PLP synthase complex.
Derrer, Bianca, Windeisen, Volker, Hipp, Katharina, Tews, Ivo, Sinning, Irmgard, Kappes, Barbara, Boettcher, Bettina, Gengenbacher, Martin, Guedez, Gabriela   +8 more
core   +1 more source

MA [PDF]

, 2007
thesis(1) Data identify the enzyme responsible for the first step in the hydrolysis of glutathione, the cleavage of the gamma glutamyl bond, as the same enzyme responsible for the hydrolysis of glutamine to glutamic acid and ammonia is reported here. (2)
Watson, Eloise Jean
core  

Glutamine metabolism, a double agent combating or fuelling hepatocellular carcinomaKey points

JHEP Reports
Summary: The reprogramming of glutamine metabolism is a key event in cancer more generally and in hepatocellular carcinoma (HCC) in particular. Glutamine consumption supplies tumours with ATP and metabolites through anaplerosis of the tricarboxylic acid ...
Razan Abou Ziki, Sabine Colnot
doaj   +1 more source

COI Form_Karine from Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia

, 2019
COI Form_Karine from Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic ...
Sergei Sukharev (2176340), Andriy Anishkin (15073533), Di Du (5576690), Marina Konopleva (31485), Thomas D. Horvath (2251825), Susan B. Rempe (1476343), Lin Tan (147501), Karine G. Harutyunyan (14998268), Philip L. Lorenzi (15073545), Michael A. Pontikos (15073530), Eric Yin (15073539), John N. Weinstein (15073542), Wai-Kin Chan (2183772), Todd Link (15073527), Leona A. Martin (15073536)   +14 more
core   +1 more source

Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival

The E3 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) is activated by the fizzy- related protein homolog/CDC20-like protein 1 (cdh1) in post-mitotic neurons.
Fuchsberger, Tanja, Teruel Martí, Vicent, Giraldo Reboloso, Esther, Lloret Alcañiz, Ana, Martínez Bellver, Sergio, Viña Ribes, José   +5 more
core   +1 more source

Understanding the cell signalization pathways that impact on glutaminase activity

, 2018
Orientadores: Sandra Martha Gomes Dias, Marília Meira DiasDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de BiologiaResumo: A proliferação celular comanda os processos de embriogênese e de crescimento do organismo, sendo essencial ...
Ascenção, Carolline Fernanda Rodrigues, 1989-
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Glutaminase activity in GLS1 Het mouse brain compared to putative pharmacological inhibition by ebselen using ex vivo MRS

, 2019
: Glutaminase mediates the recycling of neurotransmitter glutamate, supporting most excitatory neurotransmission in the mammalian central nervous system.
Mingote, Susana, Staelens, Steven, Rayport, Stephen, Chowdhury, Golam M.I., Rothman, Douglas L., Kosten, Lauren, Behar, Kevin L., Chowdhury, Golam M. I.   +7 more
core   +1 more source