Results 111 to 120 of about 27,569 (215)

Acid–Base Dysregulation Links Aging Metabolism to Frailty

Aging Cell, Volume 25, Issue 4, April 2026.
Our Metabolic Buffer Model posits that chronic acid load from aging and accumulated stressors depletes total acid buffer reserve, disrupting intersystem crosstalk. This hidden homeostatic erosion drives clinical frailty and underlies homeostatic failure during stress, unifying Rockwood's deficit accumulation and Fried's phenotype models.
Wan‐Hui Liao, Wolfgang Langhans, Maciej Henneberg   +2 more
wiley   +1 more source

Produção da enzima antileugêmica L-Asparaginase II a partir da clonagem do Gene ErA de Erwinia Carotovora Supsp. Atroseptica em Escherichia Coli [PDF]

, 2009
As enzimas L-asparaginase do tipo II catalisam a hidrólise de L-asparagina a Laspartato e amônia e, em menor quantidade, a hidrólise de L-glutamina. Escherichia coli e Erwinia chrysanthemi são as principais origens das L-asparaginases II utilizadas como ...
Wink, Priscila Lamb
core  

Structure and function of the thermostable L-asparaginase from Thermococcus kodakarensis. [PDF]

, 2017
L-Asparaginases catalyse the hydrolysis of asparagine to aspartic acid and ammonia. In addition, L-asparaginase is involved in the biosynthesis of amino acids such as lysine, methionine and threonine.
Akhtar, M, Chohan, SM, Coker, AR, Cooper, JB, Guo, J, Rashid, N, Wood, SP   +6 more
core   +1 more source

Relações entre atributos microbiológicos e bioquímicos do solo com a produtividade de soja em sistema de plantio direto. [PDF]

, 2012
O sistema de plantio direto (SPD) permite maior conservação do solo e da água, melhoria da fertilidade do solo e da atividade biológica, garantindo maior sustentabilidade ao sistema de produção.
CEREZINI, P., CERVANTES, V. N. M., FAGOTTI, D. S. L., HUNGRIA, M., NAKATANI, A. S., NOGUEIRA, M. A., SOUZA, D. I.   +6 more
core  

Diabetes Mellitus is a Risk Factor for Hepatic Encephalopathy Following Transjugular Intrahepatic Portosystemic Shunt

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 7, Page 967-978, April 2026.
Diabetes mellitus independently increases the risk of hepatic encephalopathy following TIPS placement in patients with cirrhosis. These findings emphasize the need for careful risk assessment in patients with cirrhosis and portal hypertension complications undergoing TIPS.
Michelle Spaan, Ellen Werner, Willemijn Dijkstra, Nicole E. Erler, Diederik Bijdevaate, Sarwa Darwish Murad, Milan J. Sonneveld, Caroline M. den Hoed, Anne van Eldere, Dave S. Sprengers, Willem‐Pieter Brouwer, Robert J. de Knegt, Harry L. A. Janssen, Kay Pieterman, Sandra Coenen, Raoel Maan, Adriaan J. van der Meer   +16 more
wiley   +1 more source

Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival

eLife
Photoreceptor loss results in vision loss in many blinding diseases, and metabolic dysfunction underlies photoreceptor degeneration. So, exploiting photoreceptor metabolism is an attractive strategy to prevent vision loss.
Moloy T Goswami, Eric Weh, Shubha Subramanya, Katherine M Weh, Hima Bindu Durumutla, Heather Hager, Nicholas Miller, Sraboni Chaudhury, Anthony Andren, Peter Sajjakulnukit, Li Zhang, Cagri Besirli, Costas A Lyssiotis, Thomas J Wubben   +13 more
doaj   +1 more source

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

, 2019
The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years.
Aleithe, S., Brosch, M., Brusch, L., Damm, G., Gajowski, R., Gebhardt, R., Hampe, J., Hoehme, S., Hoffmann, U., Kolbe, E., Kücken, M., Matz-Soja, M., Meierhofer, D., Ott, F., Rennert, C., Schafmayer, C., Seehofer, D., Seifert, M., Spormann, L., Stöpel, C., von Schoenfels, W.   +20 more
core   +1 more source

HuR controls glutaminase RNA metabolism

Nature Communications
AbstractGlutaminase (GLS) is directly related to cell growth and tumor progression, making it a target for cancer treatment. The RNA-binding protein HuR (encoded by the ELAVL1 gene) influences mRNA stability and alternative splicing. Overexpression of ELAVL1 is common in several cancers, including breast cancer. Here we show that HuR regulates GLS mRNA
Douglas Adamoski, Larissa M. dos Reis, Ana Carolina Paschoalini Mafra, Felipe Corrêa-da-Silva, Pedro Manoel Mendes de Moraes-Vieira, Ioana Berindan-Neagoe, George A. Calin, Sandra Martha Gomes Dias   +7 more
openaire   +3 more sources

Immunoreactivity for a calmodulin-dependent protein kinase is selectively increased in macaque striate cortex after monocular deprivation [PDF]

, 1986
Immunocytochemical methods were used to localize type II Ca2+/calmodulin-dependent protein kinase in the macaque primary visual cortex. Neurons that stain for the kinase include both pyramidal and nonpyramidal cells and they appear to form a subset of ...
Hendry, S. H. C., Kennedy, M. B.
core  

Glutaminase inhibition as potential cancer therapeutics: current status and future applications

Journal of Enzyme Inhibition and Medicinal Chemistry
Alterations in normal metabolic processes are defining features of cancer. Glutamine, an abundant amino acid in the human blood, plays a critical role in regulating several biosynthetic and bioenergetic pathways that support tumour growth. Glutaminolysis
Rajath Cyriac, Kwangho Lee
doaj   +1 more source