Results 131 to 140 of about 24,633 (278)

Glutaminase isoenzymes in the metabolic 1 therapy of cancer [PDF]

, 2018
Mensaje de la editorial Elsevier: Dear Dr. José A. Campos-Sandoval, I have attached the accepted version of your manuscript for your reference. Kindly check and let me know if you need any further assistance.
Mates-Sánchez, José Manuel, Márquez-Gómez, Javier, Campos-Sandoval, José Ángel   +2 more
core   +1 more source

An Investigation into the Impact of a Glutaminase Inhibitor, Compound 968, on Nrf2 Signaling

, 2021
Glutaminase is a critical enzyme that catalyzes the process of glutaminolysis for energy synthesis. Meanwhile, glutaminase also contributes to the pathological process of various diseases, such as cancer, neurodegenerative diseases, and inflammation ...
Wei Lei, Valentin M. Kliebe, Xin Chen
core   +1 more source

Tissue trans-glutaminase antibody in Inflammatory Bowel Disease in Golestan province, Northern Iran (2005-08)

مجله دانشگاه علوم پزشکی گرگان, 2011
Background and Objective: Celiac is a hereditary disease presented with chronic inflammation of small intestine. Several studies supposed a relationship between Celiac disease and Inflammatory Bowel Disease (IBD). Tissue trans-glutaminase antibody is one
Amiriani T, Besharat S, Semnani Sh, Joshaghani HR, Roshandel GhR, Keshtkar AA, Kiaii MR, Mirkarimi HS, Hashemi-Nasab SZ, Zendeh-Bad AS   +9 more
doaj  

Glutamine metabolism, a double agent combating or fuelling hepatocellular carcinomaKey points

JHEP Reports
Summary: The reprogramming of glutamine metabolism is a key event in cancer more generally and in hepatocellular carcinoma (HCC) in particular. Glutamine consumption supplies tumours with ATP and metabolites through anaplerosis of the tricarboxylic acid ...
Razan Abou Ziki, Sabine Colnot
doaj   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

ROLE OF CARBON SOURCE FOR THE PRODUCTION OF L-GLUTAMINASE FROM ASPERGILLUS ORYZAE

, 2014
Microbial glutaminases are more stable than plant and animal counterparts. In addition to it, they have also been detected in mammalian tissues where they are the major enzymes responsible for catabolic breakdown of glutamine. This study were taken up to
Siddalingeshwara, K G, Saroj, Yadava, PLNSN, Sunil Dutt, Naveen, M   +3 more
core   +1 more source

Safety assessment of glutaminase from Aspergillus niger

, 2020
Glutaminase (glutamine aminohydrolase EC 3.5.1.2) is used in the production of food ingredients rich in l-glutamic acid that are added to finished foods for the purpose of enhancing or improving the savory flavor profile of food.
Vo, Trung, Lynch, Barry, Go Chikamatsu, Shahrzad Tafazoli, Trung Duc Vo, Roberts, Ashley, Christina Sulaiman, Ashley Roberts, Chikamatsu, Go, Sulaiman, Christina, Barry Lynch, Tafazoli, Shahrzad   +11 more
core   +1 more source

Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

Cell Reports, 2019
SUMMARY Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GLS. The importance of the other isozyme, GLS2, in cancer has remained unclear, and it has been described as a tumor suppressor in some contexts ...
Michael J. Lukey, A. Cluntun, William P. Katt, M. Lin, J. Druso, Sekar Ramachandran, J. Erickson, H. Le, Zhihan Wang, Bryant S. Blank, K. Greene, R. Cerione   +11 more
semanticscholar   +1 more source

Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou, Sheng He, Lili He, Kun Liu, Wen Tang, Deming Wang, Jing Gui, Zhiying Zeng, Yan Wang, Wenjie Liu, Ren Jing   +10 more
wiley   +1 more source

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Yiming Yan, Yanyu Dong, Lili Zhu, JiaNing Cao, Zhirui Fan, Gautam Sethi, Lifeng Li   +10 more
wiley   +1 more source