Results 121 to 130 of about 24,633 (278)

Localization of glutaminase in rat liver

FEBS Letters, 1973
The localization of glutaminase in rat liver is not well-established although Errera [1] has demonstra- ted that phosphate-activated glutaminase is bound to insoluble liver particles and Shepherd and Kalnitsky [2] have assigned this enzyme to the 'large granular' fraction.
Kalra, J., Brosnan, J.T.
openaire   +2 more sources

Urban airborne PM2.5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb

Environmental Pollution, 2020
Emerging evidence has showed that exposure to airborne particulate matter (PM) with an aerodynamic diameter less than 2.5 μm (PM2.5) is associated with neurodegeneration.
Xiaoyu Chen, Jing Guo, Yunlong Huang, Shan Liu, Ying Huang, Zezhong Zhang, Fang Zhang, Zhongbing Lu, Fang Li, Jialin C. Zheng, Wenjun Ding   +10 more
semanticscholar   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Lysine lactylation‐mediated post‐translational modification: Molecular mechanisms and therapeutic target exploration in tumour drug resistance

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Lysine lactylation (Kla) serves as a metabolic–epigenetic switch governed by writer–eraser–reader regulatory systems, directly connecting the Warburg effect to diverse forms of tumour drug resistance. Intratumoural lactylation critically contributes to treatment failure in chemotherapy, targeted therapy and immunotherapy.
Juan Li, Yan Shang, Haojie Wu, Shenglong Yang, Maiqun Zuo, Hailong Zhao   +5 more
wiley   +1 more source

The Glutaminase-Dependent System Confers Extreme Acid Resistance to New Species and Atypical Strains of Brucella

Frontiers in Microbiology, 2017
Neutralophilic bacteria have developed specific mechanisms to cope with the acid stress encountered in environments such as soil, fermented foods, and host compartments. In Escherichia coli, the glutamate decarboxylase (Gad)-dependent system is extremely
Luca Freddi, Maria A. Damiano, Laurent Chaloin, Eugenia Pennacchietti, Sascha Al Dahouk, Stephan Köhler, Daniela De Biase, Alessandra Occhialini   +7 more
doaj   +1 more source

Immediate response of soil nitrogen cycling‐related enzyme activities to typhoon disturbance along a gap size gradient

Ecosphere, Volume 17, Issue 6, June 2026.
Abstract Although heavy rainfall and the input of unsenescent litter produced by tropical cyclones can profoundly affect the activities of soil nitrogen (N) cycling‐related enzymes in coastal mountain forest ecosystems in the short term, the immediate responses of these enzymes to typhoon disturbances and the underlying mechanism remain unknown.
Rui Cao, Naiyue Lv, Jiashun Luo, Haipeng Lin, Yutong Chen, Qingjun Ma, Zhihui Wang, Zhuang Wang, Lifeng Wang, Qin Wang, Xuebiao Pan, Wanqin Yang   +11 more
wiley   +1 more source

Understanding the cell signalization pathways that impact on glutaminase activity

, 2018
Orientadores: Sandra Martha Gomes Dias, Marília Meira DiasDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de BiologiaResumo: A proliferação celular comanda os processos de embriogênese e de crescimento do organismo, sendo essencial ...
Ascenção, Carolline Fernanda Rodrigues, 1989-
core  

Isolasi Dan Skrining Bakteri Endofit Penghasil Enzim L-Glutaminase Dari Mangrove (Sonneratia Alba) [PDF]

, 2017
Enzim L-glutaminase merupakan enzim yang mengkatalisis dan hidrolisis dari L-glutamin menjadi L-glutamat dan ammonia. Enzim ini dapat dimanfaatkan untuk kesehatan dan pangan.
Ningrum, Fifta Frizki Setya
core  

Assembly of the eukaryotic PLP-synthase complex from plasmodium and activation of the Pdx1 enzyme

, 2012
Biosynthesis of vitamins is fundamental to malaria parasites. Plasmodia synthesize the active form of vitamin B6 (pyridoxal 5-phosphate, PLP) using a PLP synthase complex.
Böttcher, Bettina, Derrer, Bianca, Windeisen, Volker, Hipp, Katharina, Tews, Ivo, Sinning, Irmgard, Kappes, Barbara, Boettcher, Bettina, Gengenbacher, Martin, Guedez, Gabriela   +9 more
core   +1 more source

De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition

Molecular Systems Biology, 2017
Cyclin‐dependent kinases (CDK) are rational cancer therapeutic targets fraught with the development of acquired resistance by tumor cells. Through metabolic and transcriptomic analyses, we show that the inhibition of CDK4/6 leads to a metabolic ...
Míriam Tarrado‐Castellarnau, Pedro de Atauri, Josep Tarragó‐Celada, Jordi Perarnau, Mariia Yuneva, Timothy M Thomson, Marta Cascante   +6 more
doaj   +1 more source