Results 61 to 70 of about 24,633 (278)
Optimization Of Culture Conditions For Maximizing L-glutaminase Production From The Marine Fungus Aspergillus flavus [PDF]
Delta Journal of ScienceMarine fungi have the capacity to extreme environments and live in a highly competitive ecological position make them suppliers of novel metabolites as L-glutaminase which is medically useful in the pharmaceutical industry, as an antioxidant and ...
Omyma Awadalla +3 more
doaj +1 more source
Occurrence of Glutaminase in Endamoeba histolytica [PDF]
Nature, 1957 THE existence of glutaminase in bacteria has been demonstrated1–3. However, to our knowledge no work has been done on other micro-organisms such as Protozoa. Little is known on the enzymatic make-up of Endamoeba histolytica 4. Recently, proteolytic enzymes were demonstrated in the amoebae5. Since a method became available for obtaining large quantities
M, NAKAMURA, L, GOLDSTEIN
openaire +2 more sources
Glutaminase - A potential target for cancer treatment
BioMedicineThe overexpression of glutaminase is reported to influence cancer growth and metastasis through glutaminolysis. Upregulation of glutamine catabolism is recently recognized as a critical feature of cancer, and cancer cells are observed to reprogram ...
Josephine Anthony +5 more
semanticscholar +1 more source
Research Progress in Improving Efficacy of Radiotherapy by Targeting Glutamine Metabolism
Zhongliu Fangzhi Yanjiu, 2023 Radiotherapy is an important treatment method for malignant tumors. Radiation resistance is the main obstacle to the therapeutic effect of radiotherapy. Cellular metabolic reprogramming is one of the main features of cancer, and it may have an important ...
QIAO Wanjia, DONG Na, LIU Xiaojun
doaj +1 more source
Advanced Science, EarlyView.The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu +10 more
wiley +1 more source
Bioresources and BioprocessingThe current investigation reports anti-cancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) and L-Glutaminase capped nanoparticles.
Zabin K. Bagewadi +4 more
doaj +1 more source
Redox Biology, 2021 Prolonged hyperglycemia plays a major role in the progression of β-cell loss in diabetes mellitus. Here we report an insulin sensitizer thiazolidinedione Pioglitazone selectively preserves the beta cells against high glucose-induced dysfunction by ...
U. Karunakaran +3 more
semanticscholar +1 more source
GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis
Advanced Science, EarlyView.This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang +9 more
wiley +1 more source
Open Medicine, 2023 Hepatocellular carcinoma (HCC) is a frequently diagnosed malignancy with a high mortality rate. Cisplatin (CDDP) is a widely applied anti-cancer drug. However, a large population of liver cancer patients developed CDDP resistance.
Tian Ruimin +3 more
doaj +1 more source
Understanding gut-liver axis nitrogen metabolism in Fatty Liver Disease
Frontiers in Endocrinology, 2022 The homeostasis of the most important nitrogen-containing intermediates, ammonia and glutamine, is a tightly regulated process in which the gut-liver axis plays a central role.
Teresa C. Delgado +6 more
doaj +1 more source