Results 51 to 60 of about 1,091,861 (290)

Evidence for Altered Glutamine Metabolism in Human Immunodeficiency Virus Type 1 Infected Primary Human CD4+ T Cells [PDF]

, 2017
Glutamine is a conditionally essential amino acid that is an important metabolic resource for proliferating tissues by acting as a proteinogenic amino acid, a nitrogen donor for biosynthetic reactions and as a substrate for the citric acid or ...
Kavanagh Williamson, Maia, Struys, Eduard, Struys, Edward, Andrea Hegedus, Khan, Mariam B., El Bacha, Tatiana, Huthoff, Hendrik, Eduard A. Struys, Struys, Eduard A., Khan, Miriam, Maia Kavanagh Williamson, Andrea T. Da Poian, El-Bacha, Tatiana, Mariam B. Khan, Julianna Dias Zeidler, Dias Zeidler, Julianna, Diaz Zeidler, Juliana, Hendrik Huthoff, Khan, Mariam Bibi, Tatiana El-Bacha, Da Poian, Andrea T., Dias Zeidler, Juliana, Hegedus, Andrea, Da Poian, Andrea   +23 more
core   +1 more source

Crystal structure of the Large Type III Glutamine Synthetase from Bacteroides Fragilis [PDF]

, 2010
Glutamine synthetases are one of the most ancient functioning enzymes in existence and these large oligomeric complexes are found in all extant forms of life where they play a critical role in nitrogen metabolism.
van Rooyen, Jason M
core   +1 more source

Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism.

PLoS ONE, 2017
Liver fibrosis is the excessive accumulation of extracellular matrix proteins, which is mainly caused by accumulation of activated hepatic stellate cells (HSCs).
Jiang Li, Mohammed Ghazwani, Ke Liu, Yixian Huang, Na Chang, Jie Fan, Fengtian He, Liying Li, Shizhong Bu, Wen Xie, Xiaochao Ma, Song Li   +11 more
doaj   +1 more source

RB in glutamine metabolism

Oncoscience, 2014
In a majority of cancer cells, inactivation of the retinoblastoma protein (pRB) through hyperphosphorylation, deletion, or mutation leads to dissociation from E2F effector proteins and aberrant activation of downstream target genes. Suppression of pRB function ultimately results in the loss of regulatory control over multiple biochemical pathways ...
openaire   +2 more sources

Glutamine Metabolism in Sepsis and Infection [PDF]

The Journal of Nutrition, 2001
Severe infection causes marked derangements in the flow of glutamine among organs, and these changes are accompanied by significant alterations in regional cell membrane transport and intracellular glutamine metabolism. Skeletal muscle, the major repository of glutamine, exhibits a twofold increase in glutamine release during infection, which is ...
A M, Karinch, M, Pan, C M, Lin, R, Strange, W W, Souba   +4 more
openaire   +2 more sources

Nitrogen metabolism in Corynebacterium glutamicum ATCC 13032 [PDF]

, 2002
Bibliography: leaves 125-146.Corynebacterium glutamicum is extensively used for the commercial production of a host of amino acids including lysine, glutamate, and threonine.
Schulz, Anton A
core   +1 more source

Visualization of glutamine transporter activities in living cells using genetically encoded glutamine sensors. [PDF]

PLoS ONE, 2012
Glutamine plays a central role in the metabolism of critical biological molecules such as amino acids, proteins, neurotransmitters, and glutathione. Since glutamine metabolism is regulated through multiple enzymes and transporters, the cellular glutamine
Katrin Gruenwald, John Todd Holland, Verlyn Stromberg, Altaf Ahmad, Daisy Watcharakichkorn, Sakiko Okumoto   +5 more
doaj   +1 more source

Glutamine metabolism in lymphocytes of the rat [PDF]

Biochemical Journal, 1983
The metabolism of glutamine in resting and concanavalin-A-stimulated lymphocytes was investigated. In incubated lymphocytes isolated from rat mesenteric lymph nodes, the rates of oxygen and glutamine utilization and that of aspartate production were approximately linear with respect to time for 60 min, and the concentrations of adenine nucleotides plus
M S, Ardawi, E A, Newsholme
openaire   +2 more sources

Parenteral glutamine in critical illness : just what the gut needs [PDF]

, 2012
The role of glutamine as a metabolic fuel for the starving intestines, its capacity to limit bacterial translocation, lung sepsis and a pro-inflammatory cytokine response are reviewed in the context of uncertainities regarding current recommendations for
Pullicino, Edgar
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source