Results 71 to 80 of about 1,150,143 (287)

Glutamine Metabolism and Prostate Cancer

Cancers
Glutamine (Gln) is a non-essential amino acid that is involved in the development and progression of several malignancies, including prostate cancer (PCa). While Gln is non-essential for non-malignant prostate epithelial cells, PCa cells become highly dependent on an exogenous source of Gln.
Erb, H., Polishchuk, N., Stasyk, O., Kahya, U., Weigel, M., Dubrovska, A.   +5 more
openaire   +3 more sources

Glutamine Metabolism and Immune Function, Supplementation and Clinical Translation.pdf

, 2018
Glutamine Metabolism and Immune Function, Supplementation and Clinical ...
Vinicius Fernandes Cruzat (5934836)
core   +1 more source

A Five Glutamine-Associated Signature Predicts Prognosis of Prostate Cancer and Links Glutamine Metabolism with Tumor Microenvironment

, 2023
Glutamine has been recognized as an important amino acid that provide a variety of intermediate products to fuel biosynthesis. Glutamine metabolism participates in the progression of the tumor via various mechanisms.
Haolin Liu, Wei Zhao, Jinze Tang, Zhongyou Xia, Yuxiao Chen, Rui Li, Peng Gu, Hai Wang, Hongtao Tu, Xiaodong Liu, Chuang Zhu, Rui Wang, Zhao, Wei, Tu, Hongtao, Zhu, Chuang, Liu, Haolin, Wang, Rui, Tang, Jinze, Liu, Xiaodong, Chen, Yuxiao, Li, Rui, Wang, Hai, Gu, Peng, Xia, Zhongyou   +23 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle

Journal of Experimental & Clinical Cancer Research
Glutamine metabolism plays a pivotal role in cancer progression, immune cell function, and the modulation of the tumor microenvironment. Dysregulated glutamine metabolism has been implicated in cancer development and immune responses, supported by ...
Bolin Wang, Jinli Pei, Shengnan Xu, Jie Liu, Jinming Yu   +4 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Metabolic phenotypes in pancreatic cancer.

PLoS ONE, 2015
IntroductionThe aim of present study was to profile the glucose-dependent and glutamine- dependent metabolism in pancreatic cancer.MethodsWe performed Immunohistochemical staining of GLUT1, CAIX, BNIP3, p62, LC3, GLUD1, and GOT1.
Min Yu, Quanbo Zhou, Yu Zhou, Zhiqiang Fu, Langping Tan, Xiao Ye, Bing Zeng, Wenchao Gao, Jiajia Zhou, Yimin Liu, Zhihua Li, Ye Lin, Qing Lin, Rufu Chen   +13 more
doaj   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Imaging the uptake and metabolism of glutamine in prostate tumor models using CEST MRI

npj Imaging
Glutamine metabolism is upregulated in many cancers. While multiple glutamine imaging agents have been developed and translated to clinical use, the short half-lives of their signal and instability in vivo limit the aspects of glutamine metabolism they ...
Yuki Hodo, Caitlin M. Tressler, Behnaz Ghaemi, Rebecca Thomas, Aliyah S. Webster, Kirsten N. Bains Williams, Yuguo Li, Martin G. Pomper, Chi V. Dang, Zaver M. Bhujwalla, Jeff W. M. Bulte, Peter C. M. van Zijl, Aline M. Thomas   +12 more
doaj   +1 more source

Suppressing glutamine metabolism in the pancreatic cancer microenvironment can enhance the anti-tumor effect of CD8 T cells and promote the efficacy of immunotherapy

Frontiers in Immunology
ObjectiveThis study aims to investigate the relationship between tumor cell glutamine metabolism and CD8 T cells, with the goal of providing new insights to improve immunotherapy for pancreatic cancer.MethodsUsing the The Cancer Genome Atlas – Pancreatic
Jun Fan, Jun Fan, Jun Fan, Jianfei Chen, Rui Wang, Rui Wang, Yisheng Peng, Sunde Tan, Sunde Tan, Xi Zhang, Xi Zhang, Hao Tang, Hao Tang, Maoshan Chen, Bo Li, Bo Li, Xiaoli Yang, Xiaoli Yang   +17 more
doaj   +1 more source