Results 61 to 70 of about 1,091,861 (290)

Metabolic Imaging of Glutamine in Cancer [PDF]

Journal of Nuclear Medicine, 2017
Glucose and glutamine are the most abundant nutrients for producing energy and building blocks in normal and tumor cells. Increased glycolysis in tumors, the Warburg Effect, is the basis for 18F-FDG PET imaging. Cancer cells can also be genetically reprogrammed to use glutamine.
Lin, Zhu, Karl, Ploessl, Rong, Zhou, David, Mankoff, Hank F, Kung   +4 more
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Glutaminase 1 isoform up-regulation associated with lipid metabolism disorder induced by methyl tertiary-butyl ether in male rats

Ecotoxicology and Environmental Safety, 2023
Methyl tertiary-butyl ether (MTBE) is a new unleaded gasoline additive, which is considered to be associated with abnormal lipid metabolism in many studies, but the metabolic characteristics and mechanism are still unclear. To observe the characteristics
Mingxiao Guo, Mengdi Li, Li Chen, Hanyun Wang, Jiajia Wang, Piye Niu, Junxiang Ma   +6 more
doaj   +1 more source

Intestinal and hepatic metabolism of glutamine and citrulline in humans

, 2007
Glutamine plays an important role in nitrogen homeostasis and intestinal substrate supply. It has been suggested that glutamine is a precursor for arginine through an intestinal-renal pathway involving interorgan transport of citrulline.
Boelens, P.G., Ligthart Melis, G.C., van Leeuwen, P.A., van de Poll, M.C., Deutz, N.E., Dejong, C.H.   +5 more
core   +1 more source

Hepatitis C virus infection triggers a tumor-like glutamine metabolism [PDF]

, 2017
Chronic infection with hepatitis C virus (HCV) is one of the main causes of hepatocellular carcinoma. However, the molecular mechanisms linking the infection to cancer development remain poorly understood.
Margarete Odenthal, Maud Michelet, Duponchel, Sarah, Dienes, Hans-Peter, Vermathen, Martina, Molle, Jennifer, Hans‐Michael Steffen, Martina Vermathen, Jennifer Molle, Eischeid, Hannah, Hannah Eischeid, Pierre L. Lévy, Michelet, Maud, Gaëlle Diserens, Zoulim, Fabien, Hans‐Peter Dienes, Dufour, Jean-François, Birke Bartosch, Bartosch, Birke, Diserens, Gaëlle, Vermathen, Peter, Steffen, Hans-Michael, Jean‐Francois Dufour, Odenthal, Margarete, Peter Vermathen, Sarah Duponchel, Fabien Zoulim, Lévy, Pierre L.   +27 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Asparagine, a critical limiting metabolite during glutamine starvation

Molecular & Cellular Oncology, 2018
A challenge of targeting glutamine metabolism in cancer is that tumor cells develop various strategies to adapt to glutamine limitation. We found that asparagine plays a critical role in supporting protein synthesis during glutamine starvation ...
Jie Jiang, Natalya N Pavlova, Ji Zhang
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Glutamine addiction in tumor cell: oncogene regulation and clinical treatment

Cell Communication and Signaling
After undergoing metabolic reprogramming, tumor cells consume additional glutamine to produce amino acids, nucleotides, fatty acids, and other substances to facilitate their unlimited proliferation.
Xian Li, Xueqiang Peng, Yan Li, Shibo Wei, Guangpeng He, Jiaxing Liu, Xinyu Li, Shuo Yang, Dai Li, Weikai Lin, Jianjun Fang, Liang Yang, Hangyu Li   +12 more
doaj   +1 more source