Results 91 to 100 of about 1,150,143 (287)
Excess glutamine rewires endothelial cell metabolism
Introduction Glutamine, the most abundant amino acid in the body, is a key metabolic substrate for endothelial cells.
Ganesh Sriram +4 more
core +1 more source
Advancing Cancer Treatment by Targeting Glutamine Metabolism—A Roadmap
, 2022 Tumor growth and metastasis strongly depend on adapted cell metabolism. Cancer cells adjust their metabolic program to their specific energy needs and in response to an often challenging tumor microenvironment.
Anna Halama, Karsten Suhre
core +1 more source
Measuring Blood Plasma Glutamine Levels Using a Nanopore‐Based Sensor
Advanced Healthcare Materials, EarlyView.Glutamine (GLN) is a biomarker useful for predicting toxic ammonia accumulation. Here, we used a biosensor based on the Cytolysin A (ClyA) nanopore coupled with the GLN‐specific protein substrate‐binding domain 2 (SBD2) to demonstrate real‐time measurement of GLN in blood plasma, highlighting the potential for future point‐of‐care applications ...
Sofia B. Relvas +9 more
wiley +1 more source
Glutamine Metabolism in Cancer: Understanding the Heterogeneity
, 2017 Reliance on glutamine has long been considered a hallmark of cancer cell metabolism. However, some recent studies have challenged this notion in vivo, prompting a need for further clarifications on the role of glutamine metabolism in cancer. We find that
Cerione, R. A. +3 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar +2 more
wiley +1 more source
Soft and Transient Bioelectronics Enabled by Polymer‐Free Ti3C2Tx MXene Hydrogels
Advanced Materials, EarlyView.We present Ti3C2Tx MXene hydrogel (MXgel) bioelectronics, a soft, flexible, and fully transient platform for high‐fidelity neural recording and stimulation. MXgel bioelectronics exhibit exceptional electrical conductivities, low electrochemical impedances, and high charge injection capacities.
Raghav Garg +15 more
wiley +1 more source
Integrated metabolomic and transcriptomic analyses reveal that glutamine promotes chicken primordial germ cell-like cell specification potentially through α-ketoglutarate [PDF]
Animal BioscienceObjective Primordial germ cells (PGCs) are essential for germline transmission and preservation of genetic resources in poultry. Despite identification of several genes and signaling pathways involved in PGC specification, the upstream regulatory ...
Qingqing Geng +11 more
doaj +1 more source
Advanced Science, EarlyView.This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang +8 more
wiley +1 more source
An introduction to glutamine metabolism
, 2017 © 2017 by Taylor & Francis Group, LLC. Hlaziwetz and Habermann rst described glutamine as a molecule with biologically important properties in 1873. They suggested that the presence of ammonia (as NH4+), detected following hydrolysis of proteins, arose
P. Newsholme (23305171) +1 more
core +2 more sources
Neural Plasticity, 2017 Type 2 diabetes mellitus (T2DM) is a risk factor for the development of Alzheimer’s disease, and changes in brain energy metabolism have been suggested as a causative mechanism.
Jens Velde Andersen +4 more
doaj +1 more source