Immunohistochemical localisation of Glutamate ammonia ligase (GLUL) in cerebrum in different clinical forms of canine rabies [PDF]
Journal of Veterinary and Animal Sciences, 2023 Rabies, one of the earliest known diseases reported in the history of mankind, is a fatal acute viral disease of the central nervous system. Despite numerous studies on etiology of rabies, its exact mechanism of neuropathogenesis remains unidentified ...
P. Nikhithasree +6 more
doaj +2 more sources
GLUL mediates FOXO3 O-GlcNAcylation to regulate the osteogenic differentiation of BMSCs and senile osteoporosis [PDF]
Cell Death and DifferentiationAbstract The abnormal osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is an important cause of senile osteoporosis (SOP). Glutamine synthetase (GLUL) is a key enzyme in glutamine biosynthesis; however, its functional role in SOP remains unclear.
Chunyang Meng +2 more
exaly +4 more sources
GLUL rs10911021 polymorphism and risk of coronary artery disease among Egyptian individuals [PDF]
Bulletin of the National Research Centre, 2019 Background Genome-wide association studies have identified novel genes related to coronary artery disease (CAD). These studies have been replicated in distinct ethnic populations, returning inconsistent results. Our work aimed to study the frequency of C
Rasha Nazih Yousef +6 more
doaj +8 more sources
Specific inhibition of glutamine synthase involved in the metabolic pathway of amino acids is associated with anti-arthritic effects of sinomenine hydrochloride [PDF]
Frontiers in Cell and Developmental BiologySinomenine (SIN) is the key bioactive alkaloid isolated from Sinomenium acutum which has been prescribed commonly in Chinese medicine for managing rheumatic disorders.
Gejing Li +9 more
doaj +2 more sources
Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction [PDF]
Frontiers in ImmunologyBackgroundPreeclampsia, a hypertensive disorder during pregnancy affecting 2-8% of pregnancies globally, remains a leading cause of maternal and fetal morbidity.
Jingjing Chen +6 more
doaj +2 more sources
Ion channels and atrial fibrillation: mitophagy as a key mediator [PDF]
Frontiers in PhysiologyBackgroundThe prevalence of atrial fibrillation (AF) is increasing due to the aging population. Mitophagy is crucial for maintaining cardiomyocyte function, while ion channels play a key role in cardiac electrical activity.
Xize Wu +10 more
doaj +2 more sources
COVID-19 multi-omics reveal organ-specific responses and biomarkers [PDF]
Journal of Translational MedicineObjective Post-COVID-19 syndrome is characterised by persistent immune dysfunction and multi-organ sequelae. This study aimed to characterise the systemic blood molecular landscape induced by SARS-CoV-2 infection and identify prognostic markers linked to
Xian Ding +10 more
doaj +2 more sources
Journal of Translational MedicineBackground Pancreatic cancer liver metastasis relies on crosstalk between pancreatic stellate cells (PSCs) and cancer cells, yet the role of transcriptional regulation in this interplay, particularly via macropinocytosis, remains unclear.
Ran Xue +5 more
doaj +2 more sources
Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity [PDF]
Cell Reports MedicineSummary: Natural killer (NK) cells exhibit impaired anti-tumor activity upon entering the tumor microenvironment (TME); however, the precise mechanism(s) remains elusive.
Rou Zhao +12 more
doaj +2 more sources
SIRT6-GLUL axis: rewiring nitrogen metabolism in intrahepatic cholangiocarcinoma. [PDF]
GutZhou H, Li H, Wu N, Calvisi DF.
europepmc +4 more sources