Results 11 to 20 of about 7,364 (182)

Immunohistochemical localisation of Glutamate ammonia ligase (GLUL) in cerebrum in different clinical forms of canine rabies [PDF]

Journal of Veterinary and Animal Sciences, 2023
Rabies, one of the earliest known diseases reported in the history of mankind, is a fatal acute viral disease of the central nervous system. Despite numerous studies on etiology of rabies, its exact mechanism of neuropathogenesis remains unidentified ...
P. Nikhithasree , C. Divya, M.L. Arya Nair, K. Krithiga, K.S. Prasanna , Lali F. Anand, John Bernet Johnson   +6 more
doaj   +2 more sources

GLUL rs10911021 polymorphism and risk of coronary artery disease among Egyptian individuals [PDF]

Bulletin of the National Research Centre, 2019
Background Genome-wide association studies have identified novel genes related to coronary artery disease (CAD). These studies have been replicated in distinct ethnic populations, returning inconsistent results. Our work aimed to study the frequency of C
Rasha Nazih Yousef, Solaf Ahmed Kamel, Nehal Salah Hasan, Mona Awad, Hesham Gamal, Nevine Ibrahim Musa, Mona Hamed Farag   +6 more
doaj   +8 more sources

GLUL mediates FOXO3 O-GlcNAcylation to regulate the osteogenic differentiation of BMSCs and senile osteoporosis [PDF]

Cell Death and Differentiation
Abstract The abnormal osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is an important cause of senile osteoporosis (SOP). Glutamine synthetase (GLUL) is a key enzyme in glutamine biosynthesis; however, its functional role in SOP remains unclear.
Bao Qi, Hongming Zhou, Lu Zhang
exaly   +4 more sources

GLUL gene knockdown and restricted glucose level show synergistic inhibitory effect on the luminal subtype breast cancer MCF7 cells’ proliferation and metastasis

EXCLI Journal : Experimental and Clinical Sciences, 2023
The glutamine synthetase path is one of the most important metabolic pathways in luminal breast cancer cells, which plays a critical role in supplying glutamine as an intermediate in the biosynthesis of amino acids and nucleotides.
Arezu Karimpur Zahmatkesh, Mohammad Khalaj-Kondori, Mohammad Ali Hosseinpour Feizi, Behzad Baradaran   +3 more
doaj   +3 more sources

Targeting the Glutamine Transporter SLC1A5 Enhances Sensitivity of Acute Myeloid Leukemia to MLN4924 [PDF]

Biomedicines
Background/Objectives: Acute myeloid leukemia (AML) remains a hematologic malignancy with poor prognosis. The neddylation inhibitor MLN4924 has demonstrated potent anti-leukemic activity in preclinical models, yet its clinical translation faces ...
Yin Wang, Yuancheng Guo, Xiao Tang, Yu Zhu, Haiping Liang, Yali Zhang, Bei Liu   +6 more
doaj   +2 more sources

ALDH1L1 reverses CD8+ T cell exhaustion in the oral squamous cell carcinoma microenvironment by reprogramming L-glutamate metabolism [PDF]

Journal of Translational Medicine
Background Oral squamous cell carcinoma (OSCC) induces CD8⁺ T-cell exhaustion within the tumor microenvironment (TME) through metabolic reprogramming, contributing to the limited efficacy of immunotherapy. Targeting tumor metabolism is a pivotal strategy.
Guanzheng Chen, Shuqi Zhao, Lin Zhu, Shifeng Wu, Jia Kang, Minghui Mao, Zhengxue Han, Yi Qu   +7 more
doaj   +2 more sources

Specific inhibition of glutamine synthase involved in the metabolic pathway of amino acids is associated with anti-arthritic effects of sinomenine hydrochloride [PDF]

Frontiers in Cell and Developmental Biology
Sinomenine (SIN) is the key bioactive alkaloid isolated from Sinomenium acutum which has been prescribed commonly in Chinese medicine for managing rheumatic disorders.
Gejing Li, Gejing Li, Zhaoli Su, Yuanyuan Tang, Hong Huang, Junlan Zhang, Ye Lin, Qin Zhang, Xiong Cai, Xiong Cai   +9 more
doaj   +2 more sources

Ion channels and atrial fibrillation: mitophagy as a key mediator [PDF]

Frontiers in Physiology
BackgroundThe prevalence of atrial fibrillation (AF) is increasing due to the aging population. Mitophagy is crucial for maintaining cardiomyocyte function, while ion channels play a key role in cardiac electrical activity.
Xize Wu, Xiaorui Yan, Ruoxi Ma, Qiuying Wu, Xue Pan, Qihua Wu, Jiaqi Ren, Yuxi Huang, Shan Gao, Yue Li, Lihong Gong   +10 more
doaj   +2 more sources

Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction [PDF]

Frontiers in Immunology
BackgroundPreeclampsia, a hypertensive disorder during pregnancy affecting 2-8% of pregnancies globally, remains a leading cause of maternal and fetal morbidity.
Jingjing Chen, Dan Zhang, Chengxiu Zhu, Lin Lin, Kejun Ye, Ying Hua, Mengjia Peng   +6 more
doaj   +2 more sources

COVID-19 multi-omics reveal organ-specific responses and biomarkers [PDF]

Journal of Translational Medicine
Objective Post-COVID-19 syndrome is characterised by persistent immune dysfunction and multi-organ sequelae. This study aimed to characterise the systemic blood molecular landscape induced by SARS-CoV-2 infection and identify prognostic markers linked to
Xian Ding, Qiuhan Lu, Ting Hu, Yi Zhang, Rui Zhao, Haolong Liu, Sicheng Huang, Yuwen Wu, Zhaohui Tong, Guozhi Jiang, Zhuoling An   +10 more
doaj   +2 more sources