Results 11 to 20 of about 200,780 (234)

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

Cell Reports, 2017
Summary Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy.
Carla Riera-Domingo, Massimiliano Mazzone, Daniel Mcvicar   +2 more
exaly   +2 more sources

Minireview on Glutamine Synthetase Deficiency, an Ultra-Rare Inborn Error of Amino Acid Biosynthesis

Biology, 2016
Glutamine synthetase (GS) is a cytosolic enzyme that produces glutamine, the most abundant free amino acid in the human body. Glutamine is a major substrate for various metabolic pathways, and is thus an important factor for the functioning of many ...
Marta Spodenkiewicz, Carmen Diez-Fernandez, Véronique Rüfenacht, Corinne Gemperle-Britschgi, Johannes Häberle   +4 more
doaj   +2 more sources

Heliorhodopsin binds and regulates glutamine synthetase activity. [PDF]

PLoS Biology, 2022
Photoreceptors are light-sensitive proteins found in various organisms that respond to light and relay signals into the cells. Heliorhodopsin, a retinal-binding membrane protein, has been recently discovered, however its function remains unknown. Herein,
Shin-Gyu Cho, Myungchul Song, Kimleng Chuon, Jin-Gon Shim, Seanghun Meas, Kwang-Hwan Jung   +5 more
doaj   +3 more sources

The Distinctive Regulation of Cyanobacterial Glutamine Synthetase

Life, 2018
Glutamine synthetase (GS) features prominently in bacterial nitrogen assimilation as it catalyzes the entry of bioavailable nitrogen in form of ammonium into cellular metabolism. The classic example, the comprehensively characterized GS of enterobacteria,
Paul Bolay, M. Isabel Muro-Pastor, Francisco J. Florencio, Stephan Klähn   +3 more
doaj   +2 more sources

cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish [PDF]

Journal of Cardiovascular Development and Disease
Carnitine palmitoyltransferase 1b (Cpt1b) is a crucial rate-limiting enzyme in fatty acid metabolism, but its role and mechanism in early cardiac development remains unclear. Here, we show that cpt1b regulates cardiomyocyte proliferation during zebrafish
Xiaohan Cheng, Jingyi Ju, Wenping Huang, Zongyi Duan, Yanchao Han   +4 more
doaj   +2 more sources

The glutamine synthetase gene family in Populus [PDF]

BMC Plant Biology, 2011
Background Glutamine synthetase (GS; EC: 6.3.1.2, L-glutamate: ammonia ligase ADP-forming) is a key enzyme in ammonium assimilation and metabolism of higher plants.
Cánovas Francisco M, Kirby Edward G, Avila Concepción, Canales Javier, García-Gutiérrez Angel, Castro-Rodríguez Vanessa   +5 more
doaj   +3 more sources

Excessive ammonium assimilation by plastidic glutamine synthetase causes ammonium toxicity in Arabidopsis thaliana

Nature Communications, 2021
Plants use nitrate, ammonium, and organic nitrogen in the soil as nitrogen sources. Since the elevated CO2 environment predicted for the near future will reduce nitrate utilization by C3 species, ammonium is attracting great interest.
Takushi Hachiya, J. Inaba, Mayumi Wakazaki, Mayuko Sato, K. Toyooka, A. Miyagi, M. Kawai‐Yamada, D. Sugiura, T. Nakagawa, Takatoshi Kiba, A. Gojon, H. Sakakibara   +11 more
semanticscholar   +1 more source

The sRNA NsiR4 is involved in nitrogen assimilation control in cyanobacteria by targeting glutamine synthetase inactivating factor IF7

Proceedings of the National Academy of Sciences of the United States of America, 2015
Martin Hagemann, Stephan Klahn, Wolfgang Hess   +2 more
exaly   +2 more sources

A naturally evolved mutation (Ser59Gly) in glutamine synthetase confers glufosinate resistance in plants

Journal of Experimental Botany, 2022
This work reveals a naturally evolving point mutation in glutamine synthetase that confers resistance to glufosinate in the globally important C4weed species Eleusine indica.
Chun Zhang, Q. Yu, Heping Han, Chaojie Yu, A. Nyporko, X. Tian, H. Beckie, S. Powles   +7 more
semanticscholar   +1 more source

Glutamine Synthetase Contributes to the Regulation of Growth, Conidiation, Sclerotia Development, and Resistance to Oxidative Stress in the Fungus Aspergillus flavus

Toxins, 2022
The basic biological function of glutamine synthetase (Gs) is to catalyze the conversion of ammonium and glutamate to glutamine. This synthetase also performs other biological functions. However, the roles of Gs in fungi, especially in filamentous fungi,
Sen Wang, Ranxun Lin, Elisabeth Tumukunde, Wanlin Zeng, Qian Bao, Shihua Wang, Yu Wang   +6 more
doaj   +1 more source