Results 11 to 20 of about 87,161 (272)

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis [PDF]

Nature, 2018
Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows negligible glutamine-synthesizing activity in these cells at physiological glutamine levels.
Eelen, Guy, Dubois, Charlotte, Cantelmo, Anna Rita, Goveia, Jermaine, Bruning, Ulrike, DeRan, Michael, Jarugumilli, Gopala, van Rijssel, Jos, Saladino, Giorgio, Comitani, Federico, Zecchin, Annalisa, Rocha, Susana, Chen, Rongyuan, Huang, Hongling, Vandekeere, Saar, Kalucka, Joanna, Lange, Christian, Morales-Rodriguez, Francisco, Cruys, Bert, Treps, Lucas, Ramer, Leanne, Vinckier, Stefan, Brepoels, Katleen, Wyns, Sabine, Souffreau, Joris, Schoonjans, Luc, Lamers, Wouter H., Wu, Yi, Haustraete, Jurgen, Hofkens, Johan, Liekens, Sandra, Cubbon, Richard, Ghesquiere, Bart, Dewerchin, Mieke, Gervasio, Francesco L., Li, Xuri, van Buul, Jaap D., Wu, Xu, Carmeliet, Peter   +38 more
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Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis. [PDF]

Cell Reports, 2017
Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy.
Castegna, Alessandra, De Tullio, Giacoma, Ghesquière, Bart, Guarini, Attilio, Hooper, D Craig, Lamers, Wouter H., Martín-Pérez, Rosa, Mazzone, Massimiliano, McVicar, Daniel W., Menga, Alessio, Palmieri, Erika M., Quinto, Annamaria, Riera-Domingo, Carla   +12 more
core   +7 more sources

Investigating the role of GLUL as a survival factor in cellular adaptation to glutamine depletion via targeted stable isotope resolved metabolomics

Frontiers in Molecular Biosciences, 2022
Cellular glutamine synthesis is thought to be an important resistance factor in protecting cells from nutrient deprivation and may also contribute to drug resistance.
Șafak Bayram, Yasmin Sophiya Razzaque, Sabrina Geisberger, Matthias Pietzke, Matthias Pietzke, Susanne Fürst, Susanne Fürst, Carolina Vechiatto, Martin Forbes, Guido Mastrobuoni, Stefan Kempa   +10 more
doaj   +1 more source

Glutamine Synthetase: Localization Dictates Outcome [PDF]

Genes, 2018
Glutamine synthetase (GS) is the adenosine triphosphate (ATP)-dependent enzyme that catalyses the synthesis of glutamine by condensing ammonium to glutamate. In the circulatory system, glutamine carries ammonia from muscle and brain to the kidney and liver.
Castegna A., Menga A.
openaire   +4 more sources

Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway

Bone Research, 2022
Ammonia plays an important role in cellular metabolism. However, ammonia is considered a toxic product. In bone marrow-derived mesenchymal stem cells, multipotent stem cells with high expression of glutamine synthetase (GS) in bone marrow, ammonia and ...
Yu Liu, Xiangxian Zhang, Wei Wang, Ting Liu, Jun Ren, Siyuan Chen, Tianqi Lu, Yan Tie, Xia Yuan, Fei Mo, Jingyun Yang, Yuquan Wei, Xiawei Wei   +12 more
doaj   +1 more source

Reduced density of glutamine synthetase immunoreactive astrocytes in different cortical areas in major depression but not in bipolar I disorder

Frontiers in Cellular Neuroscience, 2015
There is increasing evidence for disturbances within the glutamate system in patients with affective disorders, which involve disruptions of the glutamate-glutamine- cycle.
Hans-Gert eBernstein, Gabriela eMeyer-Lotz, Henrik eDobrowlny, Jana eBannier, Johann eSteiner, Martin eWalter, Martin eWalter, Bernhard eBogerts   +7 more
doaj   +1 more source

Regulation of synthesis of glutamine synthetase by adenylylated glutamine synthetase. [PDF]

Proceedings of the National Academy of Sciences, 1975
We have examined three mutants of Klebsiella aerogenes whose genetic lesions (glnB, glnD, and glnE) are in loci unlinked to the structural gene for glutamine sythetase (glnA) and in which the control of both the level and state of adenylylation of glutamine synthetase is altered. Each mutation alters a different component of the adenylylation system of
F, Foor, K A, Janssen, B, Magasanik
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Pea Leaf Glutamine Synthetase [PDF]

Plant Physiology, 1975
Of a variety of purine and pyrimidine nucleotides tested, only ADP and 5'AMP significantly inhibited the Mg(2+)-dependent activity of pea leaf glutamine synthetase. They were less effective inhibitors where Mn(2+) replaced Mg(2+). They were competitive inhibitors with respect to ATP, with inhibition constant (Ki) values of 1.2 and 1.8 mm, respectively.
T D, O'neal, K W, Joy
openaire   +2 more sources

Regulation of osmoadaptation in the moderate halophile Halobacillus halophilus : chloride, glutamate and switching osmolyte strategies [PDF]

, 2008
The moderate halophile Halobacillus halophilus is the paradigm for chloride dependent growth in prokaryotes. Recent experiments shed light on the molecular basis of the chloride dependence that is reviewed here.
Saum, Stephan H., Müller, Volker
core   +1 more source

Glutamine synthetase activity during embryonic and larval development of the silkworm Bombyx mori L. and role of a JH analogue [PDF]

, 1992
Silkworm eggs of diapause nature were chilled or treated with hydrochloric acid. Glutamine synthetase activity in such treated eggs was present soon after the treatment, whereas in non-diapause eggs it was not detectable until 24 h after the start of ...
Krishnamoorthy, R.V., Seshachalam, R.V., Subramanyam, M.V.V.   +2 more
core   +1 more source