Results 41 to 50 of about 2,024,212 (329)
Journal of Nanobiotechnology, 2021 The ratio of excitatory to inhibitory neurotransmitters is essential for maintaining the firing patterns of neural networks, and is strictly regulated within individual neurons and brain regions. Excitatory to inhibitory (E/I) imbalance has been shown to
Yunxiao Dou +5 more
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CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK. [PDF]
, 2016 BackgroundThe chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system.
Kaul, Marcus +5 more
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Lactacidosis modulates glutathione metabolism and oxidative glutamate toxicity [PDF]
Aktuelle Neurologie, 2009 J. Neurochem.(2010)113, 502–514.AbstractLactate and acidosis increase infarct size in humans and in animal models of cerebral ischemia but the mechanisms by which they exert their neurotoxic effects are poorly understood. Oxidative glutamate toxicity is a form of nerve cell death, wherein glutamate inhibits cystine uptake via the cystine/glutamate ...
Jan, Lewerenz +2 more
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Frontiers in Cellular Neuroscience, 2015 Although glutamate is one of the most important excitatory neurotransmitters of the central nervous system, its excessive extracellular concentration leads to uncontrolled continuous depolarization of neurons, a toxic process called, excitotoxicity.
Aristeidis eKritis +3 more
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Pharmaceuticals, 2022 Neurodegenerative diseases present an increasing problem as the world’s population ages; thus, the discovery of new drugs that prevent diseases such as Alzheimer’s, and Parkinson’s diseases are vital.
Varaporn Rakkhittawattana +4 more
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Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes [PDF]
Proceedings of the National Academy of Sciences, 1997 In cultured oligodendrocytes isolated from perinatal rat optic nerves, we have analyzed the expression of ionotropic glutamate receptor subunits as well as the effect of the activation of these receptors on oligodendrocyte viability. Reverse transcription–PCR, in combination with immunocytochemistry, demonstrated that most oligodendrocytes
C, Matute +3 more
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Ferrostatin-1 protects HT-22 cells from oxidative toxicity
Neural Regeneration Research, 2020 Ferroptosis is a type of programmed cell death dependent on iron. It is different from other forms of cell death such as apoptosis, classic necrosis and autophagy. Ferroptosis is involved in many neurodegenerative diseases.
Jun Chu +3 more
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Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case. [PDF]
, 2013 High concentrations of ammonium at physiological concentrations of potassium are toxic for the standard laboratory strain of Saccharomyces cerevisiae In the original description of this metabolic phenotype, we focused on the standard laboratory strains ...
Botstein, David +5 more
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The Glutamate System as a Crucial Regulator of CNS Toxicity and Survival of HIV Reservoirs
Frontiers in Cellular and Infection Microbiology, 2020 Glutamate (Glu) is the most abundant excitatory neurotransmitter in the central nervous system (CNS). HIV-1 and viral proteins compromise glutamate synaptic transmission, resulting in poor cell-to-cell signaling and bystander toxicity.
A. Górska, E. Eugenin
semanticscholar +1 more source
Nitric oxide and synaptic function [PDF]
, 1994 The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
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