Results 21 to 30 of about 78,571 (205)

Neuroprotection by cord blood stem cells against glutamate-induced apoptosis is mediated by Akt pathway

Neurobiology of Disease, 2008
The neurotransmitter glutamate mediates excitatory synaptic transmission in the brain and spinal cord. In pathological conditions massive glutamate release reaches near millimolar concentrations in the extracellular space and contributes to neuron ...
Venkata Ramesh Dasari, Krishna Kumar Veeravalli, Kay L. Saving, Meena Gujrati, Dan Fassett, Jeffrey D. Klopfenstein, Dzung H. Dinh, Jasti S. Rao   +7 more
doaj   +1 more source

Role of Aβ in Alzheimer’s-related synaptic dysfunction

Frontiers in Cell and Developmental Biology, 2022
Synaptic dysfunction is closely related to Alzheimer’s disease (AD) which is also recognized as synaptic disorder. β-amyloid (Aβ) is one of the main pathogenic factors in AD, which disrupts synaptic plasticity and mediates the synaptic toxicity through ...
Huiqin Zhang, Xuefan Jiang, Lina Ma, Wei Wei, Zehui Li, Surui Chang, Jiayu Wen, Jiahui Sun, Hao Li, Hao Li   +9 more
doaj   +1 more source

Pre- and postnatal exposure to moderate levels of ethanol can have long-lasting effects on hippocampal glutamate uptake in adolescent offspring. [PDF]

PLoS ONE, 2015
The developing brain is vulnerable to the effects of ethanol. Glutamate is the main mediator of excitatory signals in the brain and is probably involved in most aspects of normal brain function during development. The aim of this study was to investigate
Giovana Brolese, Paula Lunardi, Daniela F de Souza, Fernanda M Lopes, Marina C Leite, Carlos-Alberto Gonçalves   +5 more
doaj   +1 more source

Researching glutamate – induced cytotoxicity in different cell lines: a comparative/, collective analysis/study

Frontiers in Cellular Neuroscience, 2015
Although glutamate is one of the most important excitatory neurotransmitters of the central nervous system, its excessive extracellular concentration leads to uncontrolled continuous depolarization of neurons, a toxic process called, excitotoxicity.
Aristeidis eKritis, Eleni eStamoula, Krystallenia ePaniskaki, Theofanis eVavilis   +3 more
doaj   +1 more source

Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage

Journal of Nanobiotechnology, 2021
The ratio of excitatory to inhibitory neurotransmitters is essential for maintaining the firing patterns of neural networks, and is strictly regulated within individual neurons and brain regions. Excitatory to inhibitory (E/I) imbalance has been shown to
Yunxiao Dou, Junchao Xie, Yan Tan, Min Zhang, Yanxin Zhao, Xueyuan Liu   +5 more
doaj   +1 more source

Thunbergia laurifolia Leaf Extract Inhibits Glutamate-Induced Neurotoxicity and Cell Death through Mitophagy Signaling

Antioxidants, 2021
Oxidative stress plays a crucial role in neurodegeneration. Therefore, reducing oxidative stress in the brain is an important strategy to prevent neurodegenerative disorders.
Wudtipong Vongthip, Chanin Sillapachaiyaporn, Kyu-Won Kim, Monruedee Sukprasansap, Tewin Tencomnao   +4 more
doaj   +1 more source

Kaempferia parviflora Rhizome Extract Inhibits Glutamate-Induced Toxicity in HT-22 Mouse Hippocampal Neuronal Cells and Extends Longevity in Caenorhabditis elegans

Biology, 2021
Kaempferia parviflora Wall. ex Baker (KP) or “Kra-chai-dam” has been shown to exhibit several pharmacological effects including anti-inflammation, antimicrobial, and sexual-enhancing activity. The objectives of this study included an investigation of the
Aunchalee Tonsomboon, Mani Iyer Prasanth, Waluga Plaingam, Tewin Tencomnao   +3 more
doaj   +1 more source

Ferrostatin-1 protects HT-22 cells from oxidative toxicity

Neural Regeneration Research, 2020
Ferroptosis is a type of programmed cell death dependent on iron. It is different from other forms of cell death such as apoptosis, classic necrosis and autophagy. Ferroptosis is involved in many neurodegenerative diseases.
Jun Chu, Chen-Xu Liu, Rui Song, Qing-Lin Li   +3 more
doaj   +1 more source

Long-Term Exposure to 6-PPD Quinone Inhibits Glutamate Synthesis and Glutamate Receptor Function Associated with Its Toxicity Induction in Caenorhabditis elegans

Toxics
6-PPD quinone (6-PPDQ) is widely distributed in environments. In Caenorhabditis elegans, we first examined the effects of 6-PPDQ on glutamate synthesis and receptor function by analyzing glutamate content, related gene expression, and phenotypes after ...
Wei Wang, Yunhui Li, Dayong Wang
doaj   +1 more source

Rhinacanthin-C but Not -D Extracted from Rhinacanthus nasutus (L.) Kurz Offers Neuroprotection via ERK, CHOP, and LC3B Pathways

Pharmaceuticals, 2022
Neurodegenerative diseases present an increasing problem as the world’s population ages; thus, the discovery of new drugs that prevent diseases such as Alzheimer’s, and Parkinson’s diseases are vital.
Varaporn Rakkhittawattana, Pharkphoom Panichayupakaranant, Mani I. Prasanth, James M. Brimson, Tewin Tencomnao   +4 more
doaj   +1 more source