Results 11 to 20 of about 78,529 (248)
Neurobiology of Disease, 2009 Glutamate excitotoxicity has been implicated in the neuropathology of Huntington's disease (HD), due to the toxicity of glutamate receptor agonists on striatal medium spiny neurons (MSN), the most affected neuronal population in HD.
Ana María Estrada-Sánchez +3 more
doaj +3 more sources
KYNA Ameliorates Glutamate Toxicity of HAND by Enhancing Glutamate Uptake in A2 Astrocytes. [PDF]
Int J Mol SciReactive astrocytes are key players in HIV-associated neurocognitive disorders (HAND), and different types of reactive astrocytes play opposing roles in the neuropathologic progression of HAND. A recent study by our group found that gp120 mediates A1 astrocytes (neurotoxicity), which secrete proinflammatory factors and promote HAND disease progression.
Chen J +7 more
europepmc +3 more sources
Molecules, 2007 During our investigation of the neuroprotective activity of Platycodi radix we found that an aqueous extract of this folk medicine exhibited significant protection against glutamate-induced toxicity in primary cultured rat cortical cells.
Hyung-In Moon +4 more
doaj +3 more sources
Bilirubin in Parkinson’s disease: pathogenic mechanisms and therapeutic potentials [PDF]
Frontiers in NeuroscienceParkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, significantly impacting patients’ quality of life. Although extensive research has focused on identifying biomarkers, PD diagnosis still relies heavily on clinical features.
Yuping Wan +4 more
doaj +2 more sources
Glutamate-Independent Calcium Toxicity [PDF]
Stroke, 2007 It is widely accepted that a critical factor in determining neuronal death during cerebral ischemia is the progressive accumulation of intracellular Na+ ([Na+]i) and Ca2+ ([Ca2+]i) ions, which can precipitate necrosis and apoptosis of vulnerable neurons.
ANNUNZIATO, LUCIO +4 more
openaire +6 more sources
Natural products as safeguards against monosodium glutamate-induced toxicity [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Monosodium glutamate is a sodium salt of a nonessential amino acid, L-glutamic acid, which is widely used in food industry. Glutamate plays an important role in principal brain functions including formation and stabilization of synapses, memory ...
Mahdi Hajhasani +4 more
doaj +1 more source
Response of tyramine and glutamate related signals to nanoplastic exposure in Caenorhabditis elegans
Ecotoxicology and Environmental Safety, 2021 Neurotransmission related signals are involved in the control of response to toxicants. We here focused on the tyramine and the glutamate related signals to determine their roles in regulating nanoplastic toxicity in Caenorhabditis elegans.
Shuting Wang +3 more
doaj +1 more source
Glutamate transmission and toxicity in alzheimer's disease [PDF]
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1988 1. Despite intensive research, the cause of Alzheimer's disease is unknown. 2. Glutamate is the major excitatory transmitter of the cerebral cortex and hippocampus and it appears to have an important role in learning and memory. In addition to its transmitter function, glutamate is a neurotoxin which has been implicated in the pathogenesis of a variety
Greenamyre, J. Timothy +4 more
openaire +3 more sources
Modulation of Monosodium Glutamate Induced Histological Injuries, Histomorphometrical Alterations and DNA Damage in the Mice Hepatic and Renal Tissues by Oral Administration Nano-Cerium Oxide and L-arginine and their Combination [PDF]
The Egyptian Journal of Histology, 2020 Background: Monosodium glutamate is widely used as flavor enhancer/food additive. Many studies confirmed toxicity of monosodium glutamate even if in low concentrations especially in hepatic and renal organs.
sherin hamad, hanan hamad
doaj +1 more source
Biology, 2021 Despite the Tiger Milk Mushroom Lignosus rhinocerus (LR) having been used as a traditional medicine, little is known about the neuroprotective effects of LR extracts.
Parinee Kittimongkolsuk +4 more
doaj +1 more source