Molecular Mechanisms of Glutamate Toxicity in Parkinson’s Disease [PDF]
Frontiers in Neuroscience, 2020 Parkinson’s disease (PD) is a common neurodegenerative disease, the pathological features of which include the presence of Lewy bodies and the neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta.
Ji Wang +10 more
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Chronic glutamate toxicity in neurodegenerative diseases-what is the evidence? [PDF]
Frontiers in Neuroscience, 2015 Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain. Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate receptors) and a class of G-protein coupled receptors (metabotropic glutamate ...
Pamela eMaher, Jan eLewerenz
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Astrocyte senescence promotes glutamate toxicity in cortical neurons. [PDF]
PLoS ONE, 2020 Neurodegeneration is a major age-related pathology. Cognitive decline is characteristic of patients with Alzheimer's and related dementias and cancer patients after chemo- or radio-therapies.
Chandani Limbad +7 more
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Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect [PDF]
Journal of Traditional and Complementary Medicine, 2020 Neurodegenerative diseases (NDD) are a range of debilitating conditions of the brain involving progressive loss of neurons, many of which are still currently incurable despite enormous efforts on drug discovery and development in the past decade.
Anchalee Prasansuklab +2 more
doaj +2 more sources
Mitochondrial Cyclosporine A-Independent Palmitate/Ca2+-Induced Permeability Transition Pore (PA-mPT Pore) and Its Role in Mitochondrial Function and Protection against Calcium Overload and Glutamate Toxicity [PDF]
Cells, 2021 A sharp increase in the permeability of the mitochondrial inner membrane known as mitochondrial permeability transition (or mPT) occurs in mitochondria under the conditions of Ca2+ and ROS stress.
Galina D. Mironova, Evgeny V. Pavlov
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Interplay between Energy Supply and Glutamate Toxicity in the Primary Cortical Culture [PDF]
BiomoleculesLimited substrate availability because of the blood–brain barrier (BBB) has made the brain develop specific molecular mechanisms to survive, using lactate synthesized by astrocytes as a source of energy in neurons.
Annette Vaglio-Garro +6 more
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Comparative Study of the Protective and Neurotrophic Effects of Neuronal and Glial Progenitor Cells-Derived Conditioned Media in a Model of Glutamate Toxicity In Vitro [PDF]
Biomolecules, 2023 Cell therapy represents a promising approach to the treatment of neurological diseases, offering potential benefits not only by cell replacement but also through paracrine secretory activities. However, this approach includes a number of limiting factors,
Georgy Leonov +5 more
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SLC38A10 Transporter Plays a Role in Cell Survival Under Oxidative Stress and Glutamate Toxicity [PDF]
Frontiers in Molecular Biosciences, 2021 Solute carrier (SLC) transporters regulate amino acids, glucose, ions, and metabolites that flow across cell membranes. In the brain, SLCs are the key regulators of neurotransmission, in particular, the glutamate/GABA-glutamine (GGG) cycle.
Rekha Tripathi +2 more
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Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex [PDF]
Neurobiology of Disease, 2007 In addition to the loss of spinal motor neurons, amyotrophic lateral sclerosis (ALS) is also associated with degeneration of corticospinal layer V pyramidal neurons and decreased glutamate transport in the cortex. We characterized the glutamate receptors
Kate C. Young +2 more
doaj +3 more sources
In vivo evidence of glutamate toxicity in multiple sclerosis. [PDF]
Ann Neurol, 2014 ObjectiveThere is increasing evidence that altered glutamate (Glu) homeostasis is involved in the pathophysiology of multiple sclerosis (MS). The aim of this study was to evaluate the in vivo effects of excess brain Glu on neuroaxonal integrity measured by N‐acetylaspartate (NAA), brain volume, and clinical outcomes in a large, prospectively followed ...
Azevedo CJ +8 more
europepmc +7 more sources