Results 61 to 70 of about 2,024,212 (329)

A multifaceted review of monosodium glutamate effects on human health and its natural remedies

Food Materials Research, 2023
Monosodium glutamate is a non-essential amino acid in the human body that has been widely used as a food additive since 1909 due to its unique umami taste.
Li Yang, Yongchao Gao, Jupeng Gong, Liang Peng, Hesham R. El-Seedi, Mohamed A. Farag, Yonghua Zhao, Jianbo Xiao   +7 more
doaj   +1 more source

Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]

, 2019
Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix, Krech, Jana, Rolfs, Nele, Schmitt, Katharina R. L., Tong, Giang, Wowro, Sylvia J.   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Neuroprotective Activity of Triterpenoid Saponins from Platycodi radix Against Glutamate-induced Toxicity in Primary Cultured Rat Cortical Cells

Molecules, 2007
During our investigation of the neuroprotective activity of Platycodi radix we found that an aqueous extract of this folk medicine exhibited significant protection against glutamate-induced toxicity in primary cultured rat cortical cells.
Hyung-In Moon, Hyun Duk Yang, Sung Ik Lee, Yong Hoon Park, Il Hong Son   +4 more
doaj   +1 more source

Transport of BMAA into Neurons and Astrocytes by System x\u3csub\u3ec\u3c/sub\u3e- [PDF]

, 2018
The study of the mechanism of β-N-methylamino-l-alanine (BMAA) neurotoxicity originally focused on its effects at the N-methyl-d-aspartate (NMDA) receptor. In recent years, it has become clear that its mechanism of action is more complicated.
Albano, Rebecca, Lobner, Doug
core   +1 more source

Co-Catalytic Metallopeptidases as Pharmaceutical Targets [PDF]

, 2003
Understanding the reaction mechanism of co-catalytic metallopeptidases provides a starting point for the design and synthesis of new molecules that can be screened as potential pharmaceuticals. Many of the enzymes that contain co-catalytic metallo-active
Bzymek, Krzysztof P., Holz, Richard C., Swierczek, Sabina I.   +2 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Design, synthesis, and characterization of novel system xC − transport inhibitors: inhibition of microglial glutamate release and neurotoxicity

Journal of Neuroinflammation, 2023
Neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via the system xC − (SxC −) cystine-glutamate antiporter. With the aim of mitigating this source of neuronal stress and toxicity, we have
Mariusz P. Gajewski, Steven W. Barger
doaj   +1 more source

To respond or not to respond? Natural variation of root architectural responses to nutrient signals [PDF]

, 2017
The amino acid glutamate (Glu) acts as a fast excitatory neurotransmitter in mammals. Its importance in plant signalling was recognized with the discovery of channel proteins similar to mammalian Glu receptors, as well as distinct changes in root-system ...
Amtmann, Anna, Shahzad, Zaigham
core   +1 more source

The Role of Monoamine Metabolism in Oxidative Glutamate Toxicity [PDF]

The Journal of Neuroscience, 1996
Glutamate kills neuronal cells by either a receptor-mediated pathway or the inhibition of cystine uptake, the “oxidative pathway.” Antioxidants can block cell death initiated by either pathway, suggesting that toxicity is dependent on the production of free radicals. We provide evidence that in a neuronal cell line, glutamate toxicity via the oxidative
P, Maher, J B, Davis
openaire   +2 more sources